Introduction
ResolveMass Laboratories Inc. is a trusted partner for pharmaceutical, biotechnology, and chemical companies across Canada and the USA. The laboratory provides a wide selection of Analytical Instruments at ResolveMass, designed to deliver precise, reliable, and regulatory-compliant testing. From chromatography to spectroscopy, every instrument is optimized to provide accurate data for product development, quality assurance, and safety studies. By combining modern technology with expert scientific guidance, ResolveMass ensures validated results that are suitable for both research and regulatory use. This professional yet client-focused approach makes ResolveMass a preferred choice in highly regulated industries.
Quick Summary of Analytical Instruments at ResolveMass
- High-Performance Liquid Chromatography (HPLC): Used for impurity profiling and quantitative analysis.
- Gas Chromatography (GC) and Residual Solvent Testing: Essential for detecting volatile compounds.
- Nuclear Magnetic Resonance (NMR): Applied for molecular structure elucidation.
- Gel Permeation Chromatography (GPC): Provides detailed polymer and macromolecule analysis.
- Direct Infusion Mass Spectrometry (MS): Rapid tool for drug and biomolecule testing.
- Liquid Chromatography–Mass Spectrometry (LCMS): Combines separation and detection for biomarker analysis, drug metabolism, and quantitative studies.
- High-Resolution Mass Spectrometry (HRMS): Enables precise molecular characterization and accurate mass determination.
- Differential Scanning Calorimetry (DSC): Used to study thermal transitions such as melting point, crystallinity, and purity.
- Thermogravimetric Analysis (TGA): Measures thermal stability and decomposition behavior of materials.
- Fourier Transform Infrared Spectroscopy (FTIR): Identifies functional groups and chemical bonding in compounds.
- Gas Chromatography with Flame Ionization Detector (GCFID): Detects and quantifies volatile organic compounds with high sensitivity.
- Gas Chromatography–Mass Spectrometry (GCMS): Powerful technique for compound identification and trace-level analysis.
Each instrument contributes to advancing pharmaceutical and chemical research. By combining these techniques, ResolveMass offers both routine and highly specialized solutions tailored to client needs.
Why Analytical Instruments at ResolveMass Laboratories Stand Out
ResolveMass sets itself apart by offering not only advanced instruments but also the expertise of highly skilled scientists. Each tool is carefully chosen to meet the high standards of pharmaceutical research, regulatory compliance, and material science studies. Unlike many laboratories that provide testing only, ResolveMass combines scientific expertise with advanced technology to deliver accurate and actionable results.
The laboratory also operates under FDA, Health Canada, and international regulations, giving clients confidence that their results are globally accepted. This ensures every project is carried out with precision, accuracy, and compliance.
High-Performance Liquid Chromatography (HPLC)
HPLC remains one of the most reliable techniques at ResolveMass for separating, identifying, and quantifying compounds. It is applied to a variety of essential studies, such as:
- Impurity profiling. Learn More
- Pharmaceutical stability studies
- Active ingredient quantification
📌 Quick Answer: HPLC is considered the gold standard for impurity detection and quantitative analysis.
By using validated methods, ResolveMass provides highly reproducible data that align with strict international standards. This makes HPLC a cornerstone of both drug development and post-market quality control.
Gas Chromatography for Residual Solvent Testing
Gas Chromatography (GC) at ResolveMass specializes in detecting residual solvents at trace levels, ensuring compliance with ICH guidelines. This method is vital in confirming the safety of pharmaceutical products.
- Residual Solvent Testing Service: Read Details
- Identifies solvents left over from manufacturing processes
- Verifies compliance with regulatory standards to protect patient safety
📌 Quick Answer: GC ensures residual solvents are within safe, acceptable limits.
With its high sensitivity and accuracy, ResolveMass GC testing helps clients avoid costly recalls and regulatory concerns.
Nuclear Magnetic Resonance (NMR) Spectroscopy
NMR spectroscopy delivers detailed molecular insights, confirming structures and analyzing unknown compounds with precision. ResolveMass offers NMR services such as:
- ResolveMass NMR Service
- Small molecule analysis for APIs
- Support for research and development projects
📌 Quick Answer: NMR reveals molecular structures with unmatched accuracy.
This technique is valuable in both academic research and industrial applications. By offering NMR, ResolveMass helps clients accelerate discovery while maintaining scientific reliability.
Gel Permeation Chromatography (GPC)
GPC is crucial for studying polymers, excipients, and macromolecules in pharmaceutical and chemical products. At ResolveMass, GPC is used to:
- Determine molecular weight distribution
- Conduct quality control for polymers in formulations
📌 Quick Answer: GPC provides insights into the size distribution of macromolecules.
The data supports stability, performance, and compliance requirements, which are vital for industries where polymer behavior impacts product quality.
👉 Learn about GPC at ResolveMass
Direct Infusion Mass Spectrometry
Direct Infusion Mass Spectrometry (MS) is one of the fastest and most powerful techniques at ResolveMass. It is especially effective for:
- Drug development and biomolecule studies
- Reducing preparation time with direct sample analysis
📌 Quick Answer: Direct infusion MS offers fast and reliable molecular analysis.
By delivering immediate results, this technique shortens timelines for pharmaceutical development and biomolecular research.
👉 Explore Direct Infusion Service
Liquid Chromatography–Mass Spectrometry (LC–MS)
LC–MS combines the separation power of liquid chromatography with the detection precision of mass spectrometry. At ResolveMass, LC–MS is a key tool for:
- Identifying trace impurities and degradation products
- Quantifying low-concentration analytes in complex matrices
- Supporting metabolite and pharmacokinetic studies
📌 Quick Answer: LC–MS enables highly sensitive detection of compounds that are often missed by standard chromatographic methods.
The technique is especially valuable for pharmaceutical development, where precise molecular characterization is critical for regulatory submissions.
High-Resolution Mass Spectrometry (HRMS)
HRMS at ResolveMass provides exact mass measurements that allow unambiguous identification of molecular structures. This is essential for:
- Confirming elemental compositions
- Detecting unknown compounds with high confidence
- Supporting impurity identification and structural elucidation
📌 Quick Answer: HRMS delivers unmatched accuracy in molecular weight determination, ensuring reliable results for complex samples.
With its advanced resolution, HRMS enables researchers to differentiate between compounds with very similar molecular masses.
Differential Scanning Calorimetry (DSC)
DSC testing at ResolveMass evaluates the thermal properties of materials by measuring heat flow during temperature changes. Applications include:
- Determining melting points and glass transition temperatures
- Assessing crystallinity in pharmaceutical substances
- Studying compatibility of drug–excipient mixtures
📌 Quick Answer: DSC reveals how compounds respond to heat, making it crucial for formulation and stability studies.
This method supports both early-stage development and final product quality testing.
Thermogravimetric Analysis (TGA)
TGA measures changes in a sample’s weight as it is heated, providing insights into thermal stability and composition. ResolveMass applies TGA for:
- Evaluating moisture and volatile content
- Studying thermal degradation profiles
- Supporting material qualification for regulatory compliance
📌 Quick Answer: TGA offers direct information about a material’s thermal resistance and composition.
Its ability to detect mass changes makes TGA indispensable for polymers, excipients, and active pharmaceutical ingredients.
Fourier Transform Infrared Spectroscopy (FTIR)
FTIR spectroscopy at ResolveMass identifies functional groups and verifies chemical structures through infrared absorption patterns. Key applications include:
- Confirming raw material identity
- Detecting polymorphic forms
- Characterizing impurities and degradation products
📌 Quick Answer: FTIR provides a molecular fingerprint that verifies the authenticity and consistency of substances.
This fast, non-destructive method strengthens quality control in both R&D and manufacturing environments.
Gas Chromatography with Flame Ionization Detection (GC–FID)
GC–FID is a robust method for quantifying volatile organic compounds with high precision. At ResolveMass, it is routinely used for:
- Quantitative analysis of residual solvents
- Determining hydrocarbon content in mixtures
- Supporting batch release testing for compliance
📌 Quick Answer: GC–FID delivers reliable quantification of volatile substances with excellent sensitivity.
The technique’s reproducibility makes it a preferred choice for regulatory testing and routine quality assurance.
Gas Chromatography–Mass Spectrometry (GC–MS)
GC–MS combines the separating ability of gas chromatography with the molecular identification power of mass spectrometry. ResolveMass uses GC–MS for:
- Identifying unknown volatile impurities
- Conducting sensitive residual solvent and trace contaminant analysis
- Supporting forensic, environmental, and pharmaceutical studies
📌 Quick Answer: GC–MS provides both qualitative and quantitative insights into volatile and semi-volatile compounds.
Its dual capabilities make GC–MS one of the most versatile analytical tools available at ResolveMass.
Summary Table of Instruments at ResolveMass
| Instrument Type | Main Use Case | ResolveMass Service Link |
|---|---|---|
| HPLC | Impurity profiling, stability | HPLC Service |
| GC | Residual solvent detection | Residual Solvent Testing |
| NMR | Structure elucidation | NMR Service |
| GPC | Polymer analysis | GPC Service |
| Direct Infusion MS | Rapid drug screening | Direct Infusion |
| LCMS | Quantitative analysis, biomarker detection | LCMS Service |
| HRMS | High-precision molecular characterization | HRMS Service |
| DSC | Thermal transitions, purity | DSC Service |
| TGA | Decomposition, stability | TGA Service |
| FTIR | Functional group identification | FTIR Service |
| GCFID | Volatile organic compounds detection | GCFID Service |
| GCMS | Compound identification, trace analysis | GCMS Service |
This table provides a quick overview, making it easier for clients to select the right analytical service for their needs.
Conclusion
The wide range of Analytical Instruments at ResolveMass ensures accurate, validated, and regulatory-ready testing services for clients across Canada and the USA. From HPLC and GC to NMR, GPC, and advanced thermal stability studies, the laboratory provides solutions that support both research and compliance needs. By combining expertise with modern technology, ResolveMass delivers results that clients can trust for critical decision-making.
For tailored support, visit the Contact Page and connect with the team.
FAQs: Analytical Instruments at ResolveMass Laboratories
ResolveMass stands out because it combines advanced instruments with the knowledge of highly experienced scientists. The team ensures that every test meets strict global regulatory requirements, giving clients results they can trust for both research and submissions.
Yes, ResolveMass provides custom method development tailored to client needs. This service helps organizations meet specific regulatory requirements while ensuring accuracy, reproducibility, and compliance in every project.
Yes, ResolveMass specializes in services that align with FDA, Health Canada, and other international standards. This ensures that results are suitable for both local and global regulatory submissions.
NMR testing at ResolveMass requires only a small amount of sample, usually a few milligrams of pure compound. This makes the service accessible while still providing highly detailed molecular-level insights.
ResolveMass uses advanced chromatography and mass spectrometry to detect potential leachables. This ensures pharmaceutical packaging materials are safe and do not release harmful compounds into the final product.
Yes, ResolveMass offers Gel Permeation Chromatography (GPC) specifically for polymers and excipients. These tests provide data on molecular weight distribution and help in evaluating product stability and quality.
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References
- European Pharmaceutical Review. (n.d.). GE Analytical Instruments. European Pharmaceutical Review. Retrieved September 10, 2025, from https://www.europeanpharmaceuticalreview.com/content_hub/52235/ge-analytical-instruments/
- Siddiqui, M. R. (2017). Analytical techniques in pharmaceutical analysis: A review. Journal of Pharmaceutical and Biomedical Analysis, 130, 1–12. https://doi.org/10.1016/j.jpba.2016.11.014
- Kadam, P. A., & Gowekar, N. M. (2021). A review paper on validation and calibration of analytical instruments. International Journal of Pharmaceutical Research and Applications, 6(3), 379–387. https://doi.org/10.35629/7781-0603379387
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