Introduction
At ResolveMass Laboratories Inc., we provide advanced Liquid Chromatography–Mass Spectrometry (LC-MS) services to industries throughout Canada and the United States. Our laboratories are equipped with modern instruments such as the Thermo Quantiva MS, Thermo TSQ Quantum Access Max, and Sciex QTrap. These systems allow us to deliver dependable and accredited testing solutions for different fields.
LC-MS plays a crucial role in pharmaceutical development, food safety testing, biotechnology, chemical manufacturing, and environmental monitoring. By combining innovative technology with strict scientific standards, we ensure that clients receive results they can trust for both research and regulatory submissions.
Our goal is to help clients achieve precise impurity profiling, peptide characterization, biomarker quantification, nitrosamine detection, and much more. Every project is supported by expert scientists and validated workflows, ensuring quality, accuracy, and compliance.
Quick Summary of This Article
- ResolveMass Laboratories provides advanced Liquid Chromatography–Mass Spectrometry (LC-MS) testing services across Canada and the USA.
- Available instruments include the Thermo Quantiva MS, Thermo TSQ Quantum Access Max, and Sciex QTrap.
- LC-MS supports applications such as residual solvent testing, impurity profiling, nitrosamine analysis, peptide sequencing, PFAS testing, and other specialized studies.
- Industries served include pharmaceuticals, biotechnology, food and beverage, environmental testing, and chemical manufacturing.
- Our team combines advanced instrumentation, validated methodologies, and experienced scientists.
- Clients benefit from fast turnaround times, strict compliance, and access to services across both Canada and the United States.
Why Choose LC-MS Testing at ResolveMass Laboratories?
Liquid Chromatography–Mass Spectrometry (LC-MS) is recognized for its unmatched accuracy in detecting and quantifying complex molecules. It is one of the most powerful methods in analytical science, offering superior sensitivity compared to traditional testing techniques such as HPLC. At ResolveMass, these instruments are operated by highly skilled and experienced scientists with experience in GxP-regulated environments.
Working with ResolveMass offers several advantages. Clients benefit from trace-level sensitivity, reliable detection of impurities, and a wide range of applications covering pharmaceuticals, peptides, and biomarkers. Our validated methods follow FDA, Health Canada, and ICH guidelines, ensuring every analysis is both compliant and reproducible.
In addition, we place strong emphasis on quality assurance. Each test is performed under strict QA/QC systems, so clients receive results that are not only precise but also consistent across multiple testing cycles. This combination of expertise and reliability makes ResolveMass a trusted partner for regulated industries.
LC-MS Instruments Available at ResolveMass Laboratories
1. Thermo Quantiva MS
The Thermo Quantiva MS is a triple quadrupole LC-MS/MS system designed for highly sensitive and accurate quantification. At ResolveMass, this platform is essential for studies such as nitrosamine analysis, biomarker quantification, and PFAS testing.
Its advanced performance allows for detection at extremely low concentrations, which is critical in projects where compliance with strict safety regulations is required. This ensures reliable detection of contaminants even in highly complex samples.
2. Thermo TSQ Quantum Access Max
The Thermo TSQ Quantum Access Max is a versatile system built for routine LC-MS quantitative studies. At ResolveMass, it is widely used for impurity profiling, and direct infusion studies.
This instrument is especially valuable for pharmaceutical quality control, as it provides consistent results for high-throughput testing. Its efficiency enables faster turnaround times, allowing clients to receive high-quality data without unnecessary delays.
3. Sciex QTrap
The Sciex QTrap system combines triple quadrupole and linear ion trap technology, giving it exceptional flexibility. ResolveMass uses this instrument for peptide characterization, deformulation studies, and peptide sequencing.
Its dual design makes it possible to both quantify molecules and analyze their structure in detail. This is particularly important in biotechnology and proteomics research, where understanding molecular details is critical.
Services Powered by Liquid Chromatography–Mass Spectrometry (LC-MS)
ResolveMass employs LC-MS across a broad range of industries and scientific needs. Some of our key services include:
| Service | LC-MS Application | Learn More |
|---|---|---|
| Impurity Profiling | Identification of drug impurities and degradants | Link |
| Nitrosamine Analysis | Accurate detection of carcinogenic nitrosamines | Link |
| Biomarker Quantification | Targeted analysis for biological studies | Link |
| Peptide Characterization | Structural analysis of peptides and proteins | Link |
| PFAS Testing | Detection of persistent PFAS compounds | Link |
| Peptide Sequencing | Determination of amino acid sequences | Link |
Each of these services is carried out using validated workflows to ensure compliance with global safety standards. Whether clients require regulatory submissions, clinical trial support, or environmental testing, our team tailors solutions to meet specific project requirements.
Geographic Reach: Canada and the United States
ResolveMass provides LC-MS testing services across Canada and the United States, making advanced analytical solutions accessible to a wide range of clients. Our laboratories support projects from early research through regulatory submission, ensuring consistency and compliance throughout the process.
We also make sample submission and communication simple across borders. With operations in both countries, clients enjoy reduced logistical challenges, faster project initiation, and seamless collaboration with our scientific team.
How LC-MS Testing Builds Confidence in Results
- Accuracy: LC-MS ensures reliable and precise results, critical for compliance.
- Versatility: Suitable for small molecules, peptides, proteins, and complex mixtures.
- Regulatory Trust: All methods align with FDA, Health Canada, and ICH guidelines.
By combining accuracy, compliance, and versatility, ResolveMass helps clients reduce risks, meet strict standards, and move forward with confidence in their data.
Conclusion
At ResolveMass Laboratories Inc., our Liquid Chromatography–Mass Spectrometry (LC-MS) services deliver accuracy, compliance, and reliability. With instruments like the Thermo Quantiva MS, Thermo TSQ Quantum Access Max, and Sciex QTrap, we provide trusted solutions for industries across Canada and the United States.
Our commitment to validated methods, regulatory alignment, and expert consultation ensures that every project is handled with precision. For businesses seeking dependable LC-MS testing, ResolveMass is a partner you can trust.
Contact ResolveMass Today for expert consultation and rapid project initiation.
Frequently Asked Questions (FAQs)
LC-MS is preferred because of its high sensitivity, selectivity, and ability to detect very small amounts of substances. Unlike many traditional methods, it can identify impurities and biomarkers at extremely low concentrations. This makes it especially valuable for regulatory testing and scientific research where precision is critical.
At ResolveMass Laboratories, we operate three advanced platforms: Thermo Quantiva MS, Thermo TSQ Quantum Access Max, and Sciex QTrap. Each instrument is chosen for its specific strengths, such as ultra-trace detection, high-throughput analysis, or structural peptide studies. Together, they allow us to meet a wide range of client needs.
Turnaround times depend on the type and complexity of the project. Most routine studies are completed within 5–20 business days. For clients with urgent needs, ResolveMass also offers expedited testing options to ensure results are delivered quickly without compromising accuracy.
Yes. Our scientific team designs custom LC-MS workflows for unique compounds, new formulations, or regulatory submissions. This service ensures that even non-standard molecules are analyzed with precision. Every method is validated to deliver reliable and reproducible results.
Quality is maintained through validated methods, frequent instrument calibration, and strict QA/QC procedures. Each analysis is performed with a focus on accuracy and reproducibility. Clients can trust that the results they receive meet both scientific and regulatory expectations.
Yes. With highly sensitive instruments such as the Thermo Quantiva MS, our team can detect impurities and contaminants at levels far below regulatory limits. This ensures compliance with industry requirements while also providing an additional layer of safety and confidence for clients.
References
- Simon, R., Paul, A., Zachariah, N. M., Parvathypriya, C., Sreekumar, K., & Lakshmi, R. (2020). Amisulpride induced dyspnoea—a case report. Research Journal of Pharmacy and Technology, 13(1), 96–97. https://doi.org/10.5958/0974-360X.2020.00018.9
- Pitt, J. J. (2009). Principles and applications of liquid chromatography–mass spectrometry in clinical biochemistry. Clinical Biochemistry Reviews, 30(1), 19–34. https://doi.org/10.5958/0974-360X.2020.00018.9
- European Pharmaceutical Review. (n.d.). Liquid Chromatography – Mass Spectrometry (LC-MS). European Pharmaceutical Review. Retrieved September 15, 2025, from https://www.europeanpharmaceuticalreview.com/topic/liquid-chromatography-mass-spectrometry-lcms/
- Faizan, S., Faiz, P., Aakib, S., Ahmed, A., & Khan, G. J. (2023). Review on liquid chromatography-mass spectroscopy overview. International Journal of Research in Pharmacy and Allied Science, 2(6), 115–126. https://idealpublication.in/wp-content/uploads/2024/01/11-Review-on-Liquid-Chromatography-Mass-Spectroscopy-Overview.pdf
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