ResolveMass Laboratories Inc. Introduces Advanced Mass Spectrometry Capabilities

ResolveMass Laboratories Inc. Introduces Advanced Mass Spectrometry Capabilities

ResolveMass Laboratories Inc. announces a significant enhancement in its analytical capabilities with the direct access of state-of-the-art high-resolution mass spectrometry equipment featuring Orbitrap technology from Thermo Fisher Scientific. This cutting-edge instrument empowers ResolveMass to expand its service offerings to include a range of advanced mass spectrometry-related testing, setting new industry benchmarks for precision and reliability.

The Power of High-Resolution Mass Spectrometry

Mass spectrometry (MS) is an essential tool in analytical chemistry, allowing for the identification, quantification, and structural elucidation of chemical compounds. The integration of Orbitrap technology brings a higher level of accuracy, resolving power, and sensitivity to ResolveMass Laboratories, making it a game-changer for a wide range of applications in pharmaceuticals, environmental sciences, food safety, and biomedical research.

Orbitrap technology offers unique advantages, such as:

• Unparalleled Mass Accuracy – Essential for the precise identification of unknown compounds.
• High Sensitivity – Enabling the detection of trace-level contaminants.
• Wide Dynamic Range – Accommodating complex sample matrices.
• Non-destructive Analysis – Preserving sample integrity during testing.

Advanced Testing Capabilities

The new access to high-resolution mass spectrometry with Orbitrap technology marks a milestone for ResolveMass Laboratories. This instrument enables precise and comprehensive analysis across several critical areas:

1. PFAS Testing

ResolveMass now offers comprehensive testing for Per- and Polyfluoroalkyl Substances (PFAS), a group of synthetic chemicals found in industrial applications, household products, and the environment. Due to their persistence, bioaccumulation, and potential health risks, regulatory bodies such as the EPA, FDA, and Health Canada have intensified scrutiny over PFAS contamination.

• Why is PFAS Testing Important?
  • Detects contamination in drinking water, soil, and food packaging.
  • Assists industries in meeting regulatory compliance.
  • Reduces health risks associated with long-term PFAS exposure.

The Orbitrap MS ensures accurate detection and quantification of PFAS compounds, providing critical insights into environmental and human health impacts.

2. Nitrosamine Impurity Quantification

With increasing regulatory scrutiny on nitrosamine impurities in pharmaceuticals, food, and cosmetics, ResolveMass can now provide high-precision quantification of these potentially carcinogenic compounds. Regulatory agencies, including the FDA and EMA, mandate stringent testing to prevent exposure.

• How Does Orbitrap Improve Nitrosamine Testing?
  • Enables detection at parts-per-trillion (ppt) levels.
  • Distinguishes between structurally similar impurities.
  • Ensures compliance with global safety standards.

3. Bioanalytical Quantification Testing

Mass spectrometry plays a crucial role in bioanalytical quantification, especially for pharmacokinetics (PK), pharmacodynamics (PD), and biomarker studies. The Orbitrap MS allows for high-sensitivity measurements of biomolecules, metabolites, and pharmaceuticals in biological samples such as plasma, serum, and urine.

• Key Applications:
  • Drug metabolism and pharmacokinetics (DMPK) studies.
  • Biomarker discovery for disease diagnosis.
  • Therapeutic drug monitoring (TDM).

4. Impurity Profiling in Pharmaceuticals

Pharmaceutical formulations contain trace-level impurities that must be identified and quantified to meet regulatory standards such as ICH Q3A/B. The high-resolution Orbitrap MS provides unparalleled accuracy in detecting:

• Process-related impurities.
• Degradation products.
• Residual solvents and extractables.

With compliance-driven analysis, pharmaceutical companies can ensure drug safety, stability, and efficacy.

5. Proteomics and Metabolomics Research

ResolveMass Laboratories is leveraging Orbitrap technology for proteomics and metabolomics research, enabling the study of proteins, peptides, lipids, and small molecules in biological systems. This innovation is vital for drug discovery, personalized medicine, and systems biology.

• Proteomics Applications:
  • Identifying disease biomarkers.
  • Understanding drug-target interactions.
  • Mapping protein modifications.
• Metabolomics Applications:
  • Investigating metabolic pathways in diseases.
  • Discovering novel therapeutic targets.
  • Studying environmental and nutritional impacts on health.

6. Food Safety and Contaminant Analysis

Food safety regulations require highly sensitive and accurate analytical techniques to detect contaminants, allergens, and adulterants. The Orbitrap MS is particularly effective for:

• Pesticide residue analysis.
• Mycotoxin detection in grains and food products.
• Identification of food fraud and adulteration.

With consumers demanding greater transparency, food manufacturers and regulatory agencies benefit from high-resolution screening methods to uphold food quality standards.

7. Environmental Testing and Forensic Applications

Environmental contamination poses significant public health risks, making high-resolution analytical testing a necessity. The Orbitrap MS facilitates accurate screening of:

• Industrial pollutants in air, water, and soil.
• Heavy metal contamination.
• Illicit drugs and forensic toxicology samples.

The integration of Orbitrap technology enhances the forensic science domain by enabling the detection of trace-level substances in complex forensic samples, including drug abuse screening, doping control, and criminal investigations.

Industry Impact and Client Benefits

The introduction of high-resolution mass spectrometry with Orbitrap technology underscores ResolveMass Laboratories’ commitment to scientific excellence and innovation. Clients across multiple industries stand to benefit from:

• Unmatched Analytical Precision – High-resolution data ensures confident decision-making.
• Regulatory Compliance – Meeting industry standards such as FDA, EMA, and Health Canada.
• Faster Turnaround Times – Streamlined workflows enhance efficiency.
• Cost-Effective Solutions – Advanced technology at competitive pricing.

By investing in state-of-the-art analytical solutions, ResolveMass remains at the forefront of scientific advancements, helping clients achieve breakthroughs in research, quality control, and regulatory compliance.

About ResolveMass Laboratories Inc.

ResolveMass Laboratories Inc. is a leading provider of analytical testing services and custom organic synthesis, catering to industries including pharmaceuticals, environmental science, biotechnology, and food safety. With a commitment to innovation and quality, ResolveMass offers comprehensive analytical solutions tailored to meet the evolving needs of its clients.

REFERENCES

1. Young G, Hundt N, Cole D, Fineberg A, Andrecka J, Tyler A, Olerinyova A, Ansari A, Marklund EG, Collier MP, Chandler SA. Quantitative mass imaging of single molecules in solution. Science.:423-7.
2. Wang W, Cao G, Zhang J, Qiao H, Wang F, Cai Z. Recent applications of mass spectrometry in the analysis of transformation products of emerging contaminants in PM2. 5. Analytical Science Advances. 2023 May;4(3-4):49-59.
3. Brown M, Dunn WB, Dobson P, Patel Y, Winder CL, Francis-McIntyre S, Begley P, Carroll K, Broadhurst D, Tseng A, Swainston N. Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. Analyst. 2009;134(7):1322-32.