Deuterated Propylene oxide-d6 | CAS 202468-69-7

DEUTERATED PROPYLENE OXIDE-D₆

CAS 202468-69-7

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OVERVIEW

Deuterated Propylene oxide-d6 | CAS 202468-69-7  is a fully deuterium-labeled analog of propylene oxide in which all six hydrogen atoms are replaced with deuterium (²H). This isotopic substitution increases the molecular mass while maintaining nearly identical chemical reactivity to the non-labeled compound. As a result, Propylene Oxide-d₆ serves as a highly reliable tool in analytical chemistry, reaction mechanism studies, polymer research, and isotope tracing applications.

Propylene oxide is a reactive epoxide widely used in chemical synthesis and polymer production. Its deuterated counterpart preserves the strained three-membered epoxide ring, enabling it to participate in the same nucleophilic ring-opening and polymerization reactions. However, the mass shift introduced by deuterium incorporation provides a measurable distinction in spectroscopic and mass-based detection systems. This makes Deuterated Propylene Oxide-d₆ particularly valuable for laboratories requiring high-precision quantitative analysis.

At ResolveMass Laboratories Inc., we provide high-purity isotopically labeled compounds designed to meet the needs of pharmaceutical, environmental, materials science, and academic research laboratories.

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CHEMICAL INFORMATION

• Chemical Name: Deuterated Propylene Oxide-d₆

• CAS Number: 202468-69-7

• Molecular Formula: C₃D₆O

• Molecular Weight: 58.08 g/mol

The complete replacement of hydrogen with deuterium results in a predictable mass increase of +6 atomic mass units compared to native propylene oxide. This mass difference is especially important in GC-MS and LC-MS workflows, where accurate mass discrimination is critical.

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ANALYTICAL APPLICATIONS  of  Deuterated Propylene oxide-d6 | CAS 202468-69-7

 

Stable Isotope Internal Standard

One of the primary uses of Propylene Oxide-d₆ is as an internal standard in mass spectrometry. Because the deuterated molecule behaves almost identically to its non-labeled analog during sample preparation, chromatography, and ionization, it effectively compensates for matrix effects, extraction losses, and instrumental variability. The consistent mass shift allows for accurate quantification even at trace concentration levels.

GC-MS and LC-MS Calibration

In gas chromatography-mass spectrometry (GC-MS), volatile compounds such as propylene oxide are commonly analyzed in environmental and industrial samples. The deuterated analog provides a robust calibration reference, ensuring reproducibility across analytical runs. Similarly, in LC-MS workflows involving derivatization or epoxide-related compounds, Propylene Oxide-d₆ enhances quantification reliability.

NMR Spectroscopy

Deuterium incorporation alters proton NMR signals while maintaining structural integrity. This property is beneficial in mechanistic investigations and structural confirmation studies. The isotopic substitution also reduces proton background interference in certain analytical contexts.

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RESEARCH & INDUSTRIAL APPLICATIONS

Reaction Mechanism Studies

Epoxides are central intermediates in organic synthesis. Using a deuterated version allows researchers to track bond formation and cleavage pathways with precision. Deuterium labeling is particularly valuable for studying kinetic isotope effects (KIE), which provide insight into rate-determining steps in chemical reactions.

Polymer and Materials Research

Propylene oxide is a precursor in the synthesis of polyether polyols and other polymeric materials. The deuterated analog can be used to investigate polymerization mechanisms, monitor chain growth, and analyze degradation pathways. In advanced materials research, isotopic labeling supports detailed structural and compositional analysis.

Environmental & Fate Studies

In environmental chemistry, isotopically labeled compounds are used to trace degradation pathways and monitor transformation products. Propylene Oxide-d₆ enables researchers to distinguish introduced analytes from naturally occurring background compounds, improving analytical clarity in complex matrices.

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QUALITY ASSURANCE

ResolveMass Laboratories Inc. specializes in high-purity stable isotope-labeled standards. Each batch of Deuterated Propylene Oxide-d₆ is subjected to rigorous quality control testing to verify:

• Isotopic enrichment

• Chemical purity

• Identity confirmation

• Analytical suitability

Certificates of Analysis (COA) and supporting documentation are available to ensure regulatory and research compliance. Our commitment to precision and reliability makes ResolveMass a trusted partner for laboratories requiring dependable isotope-labeled reference materials.

 

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