Introduction: Why Quality LC-MS Analysis Services Matter
In the highly regulated and precision-demanding field of pharmaceutical and chemical research, finding a trusted LC-MS Analysis Service in the United States is not just important—it’s mission-critical. At ResolveMass Laboratories Inc., we understand the stakes involved. Whether you’re working on impurity profiling, bioanalytical quantification, or regulatory submissions, accurate and reproducible LC-MS data can make or break your project.
Liquid Chromatography-Mass Spectrometry (LC-MS) combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry. It’s widely used in detecting trace-level compounds, quantifying molecules, and ensuring product safety.
What Makes an LC-MS Analysis Service Trustworthy?
1. Technical Expertise and Experience
A high-caliber LC-MS Analysis provider should have a team of skilled professionals with proven expertise. At ResolveMass Laboratories Inc., our team brings over 20 years of collective experience in mass spectrometry across diverse applications—from pharmaceuticals and biologics to environmental and food safety testing.
2. State-of-the-Art Instrumentation
Accurate results stem from reliable instruments. We use cutting-edge LC-MS/MS platforms such as QTOF and Triple Quadrupole systems to support our LC-MS Analysis Service. These instruments are maintained under strict SOPs, and calibration is routinely validated with NIST-traceable standards.
3. Method Validation and Regulatory Compliance
A credible LC-MS partner adheres to international standards such as ICH, FDA, and EMA. Our services comply with GLP and GxP, and we offer comprehensive method validation that includes system suitability, accuracy, precision, linearity, and robustness testing.
Why Choose ResolveMass Laboratories Inc. for LC-MS Analysis Service?
- Experience: Our scientists have published peer-reviewed research in the field of bioanalysis and impurity profiling.
- Expertise: We support pharmaceutical, biotech, and environmental sectors.
- Authoritativeness: Trusted by leading CROs and pharma companies in North America.
- Trustworthiness: Transparent SOPs, validated methods, and customer-centric service.
Explore more about our related services:
- Impurity Profiling Services
- Bioanalytical Quantification
- Extractables and Leachables Testing
- PFAS Testing
Key Applications of LC-MS Analysis Services
Drug Development and Bioanalytical Testing
From pharmacokinetic studies to metabolite identification, our LC-MS Analysis Service supports each step of the drug development pipeline.
Impurity and Degradation Profiling
For NDAs and ANDAs, precise impurity profiling is vital. Learn more about our Impurity Profiling capabilities.
PFAS Detection and Environmental Analysis
Using LC-MS/MS, we can detect PFAS compounds down to ppt levels. Learn more about PFAS testing at ResolveMass.
Real-Time Case Study: Supporting an ANDA Submission
Client: Mid-size U.S. pharmaceutical company
Challenge: Identify and quantify genotoxic impurities in a new generic drug to support ANDA filing.
Solution:
- Employed triple quadrupole LC-MS for targeted quantification.
- Developed a method validated for accuracy (98–102%) and precision (<2% RSD).
- Turnaround time: 10 working days
Results:
- Client successfully submitted ANDA with complete impurity profile.
- FDA review passed without queries on analytical data.
How to Evaluate the Right LC-MS Analysis Service Provider
Ask the Right Questions
- What instruments and detection limits do you use?
- Can you share validation reports or performance metrics?
- Do you offer method development or only analysis?
Check for Customization and Responsiveness
Every project is unique. A dependable LC-MS partner will tailor methods to your sample matrix and goals, and respond swiftly to inquiries.
Look for Documentation and Data Integrity
Ensure the provider complies with ALCOA+ data integrity principles. At ResolveMass, our data systems are 21 CFR Part 11 compliant.
The Future of LC-MS Analysis in the U.S.
AI-assisted analytics, miniaturized systems, and automation are reshaping LC-MS workflows. At ResolveMass, we stay ahead of the curve, integrating modern tools to enhance accuracy, reduce costs, and accelerate timelines.
FAQs on LC-MS Analysis Services in the United States
1. What is LC-MS Analysis Service used for?
LC-MS analysis is used for identifying and quantifying molecules in complex mixtures. It’s crucial in pharma for drug metabolism, in environment for pollutant detection, and in food safety.
2. How do I choose the best LC-MS Analysis Service provider?
Look for providers with experience, advanced tools, validated processes, and responsive support—ResolveMass meets all these criteria.
3. What are the detection limits for LC-MS?
Our LC-MS systems can detect compounds at parts per trillion (ppt) levels, depending on matrix and method.
4. Is method validation included in LC-MS Analysis Services?
Yes. We provide complete method validation as per ICH and FDA guidelines.
5. What is the turnaround time for LC-MS services?
Typical turnaround is 7–14 days. For urgent projects, expedited services are available.
6. Can LC-MS detect genotoxic impurities?
Absolutely. It is one of the most sensitive methods for genotoxic impurity analysis.
7. Do you offer LC-MS services for biologics?
Absolutely. We support both small molecule and biologics analysis.
8. How is data security maintained in your LC-MS services?
We use secure, audit-trailed systems in compliance with 21 CFR Part 11.
9. Can LC-MS be used for PFAS detection?
Yes. Visit our PFAS Testing page for more.
10. Where can I get more information or request a quote?
Visit our Contact Us page to get in touch.
Conclusion: Make the Smart Choice with ResolveMass
When it comes to choosing a reliable LC-MS Analysis Service in the United States, experience, accuracy, and compliance are non-negotiables. At ResolveMass Laboratories Inc., we combine scientific rigor with customer-centric solutions to ensure your analytical challenges are solved with precision. Whether you’re preparing for regulatory filing or exploratory research, trust our LC-MS Analysis Services to deliver.
ResolveMass Laboratories Inc.: Experience, Expertise, and Trust You Can Count On
ResolveMass Laboratories Inc. is a leading name in nitrosamine testing across the United States and Canada. With over a decade of experience, our PhD-level scientists specialize in Mass Spectrometry and nitrosamine impurity chemistry. We offer complete in-house solutions, including risk assessment, confirmatory analysis, regulatory documentation, and expert consultation. As one of the few Canadian CROs, we also provide custom synthesis of rare nitrosamine impurities unavailable elsewhere. Our commitment to advanced technology and regulatory compliance ensures accurate results and trusted partnerships. Choose ResolveMass Laboratories for precise and transparent nitrosamine testing services.
Ready to Get Started?
📩 Contact our expert team
📞 Request a quote for method development
📅 Book a consultation with our scientists
🧪 Submit your sample for testing
References
- Lynch, K. L. (2017). Chapter 6 – Toxicology: Liquid chromatography mass spectrometry. In H. Nair & W. Clarke (Eds.), Mass spectrometry for the clinical laboratory (pp. 109–130). Academic Press. https://doi.org/10.1016/B978-0-12-800871-3.00006-7
- Čelić, M., Farré, M., Lopez de Alda, M., Perez, S., Barceló, D., & Petrovic, M. (2023). Chapter 16 – Environmental analysis: Emerging pollutants. In S. Fanali, B. Chankvetadze, P. R. Haddad, C. F. Poole, & M.-L. Riekkola (Eds.), Liquid chromatography (Third edition) (Vol. 2, pp. 549–578). Elsevier. https://doi.org/10.1016/B978-0-323-99969-4.00014-0
