When planning analytical workflows in pharmaceuticals, biotechnology, or environmental sciences, the LCMS Analysis Service is a critical step that ensures molecular precision, regulatory compliance, and quality control. But one of the most important question the client scientist ask is : “How much does LCMS Analysis Service cost in 2025?”
As one of the top advanced testing laboratories in North America, ResolveMass Laboratories Inc. located in Montreal, Canada provides clients with LCMS Analysis Services that combine technical excellence, regulatory insight, and transparent pricing. This buyer’s detailed guide will walk you through the latest pricing models, cost influencers, and value-driven options in LCMS services so you can make a confident, informed purchase.
What Is Included in an LCMS Analysis Service?
Before we break down the cost, it’s important to understand what a typical LCMS Analysis Service includes:
- Sample preparation and purification
- LC (Liquid Chromatography) separation
- Mass spectrometric detection and analysis
- Data processing and report generation
- Method validation (if required)
Depending on your goals, you may also need method development, structural elucidation, impurity profiling, or regulatory-compliant documentation. These factors can all influence cost.
To see how this aligns with impurity profiling workflows, visit ResolveMass Impurity Profiling Services.
Average Cost of LCMS Analysis Service in 2025
In 2025, the LCMS Analysis Service cost typically depends only on two major factors. The costing of ResolveMass Laboratories Inc. is simple and straight forward, we charge based on the time of scientist and instrument hours utilized for your study. We challenge that the cost we offer will be lesser than you perform the testing in house in your laboratory without specialized expertize of Mass spectrometry.
- If the test is qualitative or direct infusion analysis, then it may cost flat rate of USD 100-350 per sample. Again, depends on number of samples, interepretation complexity etc.
- for MS Identifictation through LC or Quantification by LCMS Following variables are to be considered:
- Scientist charges : USD 100 / Hour
- Instrument LCMS/GCMS/HRMS charges: USD $150 to $350 depending on the type and model of instrument used. Usually HRMS cost is higher than the triple quod or single quod instrument.
- Comnplexity of the study also matters in some experiments.
At ResolveMass Laboratories Inc., our LCMS Analysis Services start at $100/sample, depending on complexity and turnaround requirements. Explore more here.
Key Factors That Influence LCMS Analysis Service Cost
1. Sample Type and Matrix Complexity
Analyzing a small molecule in pure water costs far less than testing a biologic in serum or an extract from plant material.
2. Test type
Is it Direct Infusion, qualitative or quantitative type of test. Mostly depends on the time of Scientist and instrument hours utilized in your test.
3. Number of Analytes or Targets
Single-target analysis is more economical. Multi-analyte panels or full scans increase processing time.
4. Turnaround Time (TAT)
Need your results within 24–48 hours? Expect an express surcharge of 25–50%.
5. Regulatory Documentation
Pharmaceutical clients may require validated methods and GLP/GMP-compliant reporting. These add to costs but are essential for FDA or Health Canada submissions.
Learn about impurity-related regulatory testing.
Customization vs Standardization in LCMS Analysis Service
ResolveMass Laboratories offers both standard LCMS Analysis Services and customized protocols for challenging matrices or novel compounds. Custom development, while more expensive upfront, ensures higher data fidelity and supports regulatory filing requirements.
Looking for custom impurity profiling in Canada or the U.S.? See our specialization in impurity testing.
Is LCMS Analysis Service Worth the Investment?
Yes—especially when working with high-value drug substances, clinical formulations, or proprietary compounds. The LCMS Analysis Service ensures:
- Precise molecular identification
- Impurity detection and quantification
- Regulatory documentation compliance
- Faster go-to-market for drug products
See how our clients benefit from our impurity profiling workflows.
Tips for Choosing the Right LCMS Analysis Service Provider
When comparing labs, consider:
- Do they offer validated LCMS Analysis Services?
- What experience do they have with your compound class?
- Can they offer fast turnaround without compromising data quality?
- Do they specialize in impurity profiling or regulatory chemistry?
ResolveMass Laboratories Inc. delivers comprehensive LCMS data supported by highly qualified PhD scientists, state-of-the-art instrumentation, and a reputation for reliability. Read more about our capabilities.
Case Example: LCMS Analysis for Nitrosamine Detection
In 2025, regulatory scrutiny around nitrosamine impurities remains high. Our LCMS Analysis Service is frequently used for:
- Confirmatory testing of trace-level impurities
- Risk-based impurity profiling
- Routine monitoring of nitrosamines in APIs and drug products
See impurity analysis case studies here.
Hidden Costs to Avoid in LCMS Analysis Service
When selecting a service provider, be cautious of:
- Unclear pricing models with hidden method development fees
- Lack of sample stability data, which may cause re-analysis
- Subcontracting labs, which may delay timelines or affect data integrity
ResolveMass Laboratories ensures transparency in every LCMS Analysis Service quote. Request your custom quote now.
Conclusion: Plan Your Budget with Confidence in 2025
Understanding the LCMS Analysis Service cost in 2025 helps you plan smarter, mitigate delays, and ensure accurate results. Whether you’re screening for impurities, characterizing complex molecules, or supporting regulatory submissions, investing in high-quality LCMS services pays dividends.
At ResolveMass Laboratories Inc., our clients count on us for precision, speed, and scientific depth. Our LCMS Analysis Service is designed to support pharmaceutical, biotech, and environmental science companies with scalable, trustworthy solutions.
To learn more about LCMS-based impurity profiling, visit our impurity testing hub.
Ready to Request a Quote?
Reach out to ResolveMass Laboratories today for customized LCMS Analysis Services:
ResolveMass Laboratories Inc.: Comprehensive Scientific Expertise You Can Rely On
ResolveMass Laboratories Inc. is a trusted Canadian contract research organization offering a wide spectrum of specialized services spanning polymer synthesis, advanced analytical testing, and custom organic synthesis. With over a decade of experience supporting pharmaceutical, biotech, and industrial clients, we bring scientific precision and regulatory insight to every project. Our core capabilities include Polymer Synthesis and Characterization, Peptide Characterization, Organic Synthesis, Nitrosamine Testing and Analysis, PFAS Testing, and Extractable & Leachable Studies, as well as a broad suite of analytical techniques such as HPLC, GC-MS, MALDI-TOF, NMR, and FTIR.
Our multidisciplinary team includes chemists, analytical scientists, and regulatory experts with advanced academic and industry backgrounds. We excel at developing customized, high-quality solutions—whether you need innovative polymer designs, impurity profiling, or confirmatory testing that meets global regulatory standards.
Clients across North America choose ResolveMass Laboratories for our deep technical knowledge, commitment to quality, and ability to deliver reproducible, reliable data that drives confident decision-making. When precision, innovation, and trust matter—ResolveMass is your partner of choice.
References
- EMA. (2021). Assessment and Mitigation of Nitrosamine Risk in Human Medicines. https://www.ema.europa.eu/en/documents/referral/nitrosamines-emea-h-a53-1490-assessment-report_en.pdf
- FDA. (2021). Control of Nitrosamine Impurities in Human Drugs. https://www.fda.gov/media/141720/download
- Health Canada. (2020). Guidance on Nitrosamine Impurities in Medications. https://www.canada.ca/en/health-canada/services/drugs-health-products.html
- ICH. (2023). ICH M7(R2) – Control of Mutagenic Impurities. https://database.ich.org/sites/default/files/M7_R2_Guideline_Step4_2023_0223.pdf
