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Peptide-Oligonucleotide Conjugates (POCs) Synthesis Services
At ResolveMass Laboratories Inc., our Peptide-Oligonucleotide Conjugates (POCs) Synthesis Services are designed to support researchers, biotech innovators, and pharmaceutical developers who require reliable, high-purity, and fully characterized conjugates for therapeutic discovery and advanced molecular biology applications. By integrating expert peptide chemistry, automated oligonucleotide synthesis, and controlled conjugation strategies under one roof, we deliver reproducible POCs with exceptional quality, enabling confident progression from early research to clinical development.
Why Peptide-Oligonucleotide Conjugates Are Transforming Modern Therapeutics
Peptide-Oligonucleotide Conjugates combine the biological specificity of peptides with the gene-modulating capability of oligonucleotides. This hybrid architecture enhances cellular uptake, improves tissue targeting, and increases stability in biological systems. As a result, POCs are increasingly used in antisense therapy, siRNA delivery, targeted diagnostics, and precision medicine programs where traditional nucleic acids alone may underperform.
- Improved cellular penetration
- Enhanced pharmacokinetics
- Tissue-specific targeting
- Reduced off-target effects
- Greater stability in serum
Explore our specialized synthesis solutions for therapeutic development: Custom Synthesis for Drug Discovery
Specialized POC Synthesis Expertise You Can Trust
Our scientific team includes experienced synthetic chemists and analytical specialists with deep backgrounds in peptide chemistry, phosphoramidite oligonucleotide synthesis, and advanced purification technologies. Every project is executed using validated protocols, controlled laboratory environments, and stringent quality systems. Clients benefit from consultative support, clear documentation, and dependable turnaround times that meet both research and regulated development needs.
Chemistry Capabilities
Solid-phase peptide synthesis, automated DNA/RNA synthesis, custom linker chemistry, click chemistry, maleimide coupling, and thiol-based conjugation strategies.
Analytical Capabilities
HPLC/UPLC purification, LC-MS confirmation, MALDI-TOF, purity profiling, and comprehensive QC reporting.
Ensure your sequences are perfectly verified with our high-end analysis: Peptide Characterization Services
Our Peptide-Oligonucleotide Conjugates (POCs) Synthesis Services Include
- Custom peptide design and synthesis
- DNA, RNA, antisense, and modified oligonucleotides
- Cleavable and non-cleavable linkers
- Site-specific or multi-site conjugation
- Fluorescent or functional labeling
- Scale-up from milligram to gram quantities
- High-purity HPLC purification
- Full analytical characterization and documentation
Our Proven Development Workflow
- Scientific consultation and feasibility review
- Sequence and linker optimization
- Controlled synthesis and conjugation
- Purification and analytical verification
- Detailed QC report and secure shipment
This structured process ensures consistency, traceability, and quality at every stage, helping researchers move forward with confidence.
Applications Across Research and Therapeutics
Our POCs support a broad spectrum of applications, including gene silencing, targeted drug delivery, molecular diagnostics, and biomarker discovery. Clients from academia, biotech startups, and established pharmaceutical organizations rely on our services to accelerate innovation while minimizing technical risk.
- Antisense oligonucleotide delivery
- siRNA conjugates
- Targeted oncology research
- Cell-penetrating peptide systems
- Imaging and diagnostic probes
- Personalized medicine development
Commitment to Quality, Compliance, and Transparency
Quality is central to every project we undertake. We operate with documented SOPs, validated instruments, and rigorous batch testing. Each order includes detailed certificates of analysis, mass confirmation, and purity reports. Our team maintains strict confidentiality and ensures reliable communication, making us a trusted partner for sensitive research and commercial programs.
Learn more about our full range of laboratory services: Visit ResolveMass Services
Why Researchers Choose ResolveMass
- Experienced scientific team
- Advanced synthesis platforms
- Accurate mass verification
- Reliable timelines
- Flexible project scaling
- Dedicated technical support
- Transparent pricing
Start Your Next Conjugation Project With Confidence
If you require dependable, analytically verified Peptide-Oligonucleotide Conjugates (POCs) Synthesis Services, our team is ready to help you design, synthesize, and deliver high-performance conjugates tailored to your research or therapeutic goals. Partner with us for scientific precision, transparent communication, and results you can trust.
Frequently Asked Questions
Peptide oligonucleotide conjugation is a chemical strategy that links a synthetic peptide to a DNA or RNA fragment to create a single functional molecule. This combination improves cellular uptake, targeting ability, and biological stability compared with free oligonucleotides alone. The peptide often acts as a delivery or targeting agent, while the oligonucleotide performs gene modulation. Such conjugates are widely explored in therapeutic and diagnostic research.
Peptides are short chains of amino acids commonly used for targeting, signaling, and therapeutic applications because of their high biological specificity. Oligonucleotides are short sequences of nucleic acids designed to bind specific genetic targets and regulate gene expression. Together, they are used in drug development, molecular diagnostics, and cell biology research. Their complementary roles enable precise intervention at the molecular level.
An example of an oligonucleotide is an antisense DNA or RNA strand designed to bind a complementary messenger RNA sequence. Small interfering RNA (siRNA) is another well-known example that selectively silences gene expression. Short PCR primers used in genetic testing are also oligonucleotides. These molecules typically range from 15 to 30 nucleotides in length depending on their purpose.
Oligonucleotides function by recognizing and binding to specific nucleic acid sequences inside cells through base pairing. This interaction can block translation, promote degradation of target RNA, or alter gene splicing patterns. By controlling how genes are expressed, they enable researchers to study biological pathways or develop targeted treatments. Their sequence specificity allows highly precise molecular control.
Like many therapeutic molecules, oligonucleotides may produce side effects depending on dosage, delivery method, and chemical modifications. Possible concerns include immune stimulation, mild injection site reactions, or unintended off-target gene effects. Modern design strategies and purification techniques significantly reduce these risks. Careful formulation and testing improve safety profiles in clinical applications.
The mechanism of action involves sequence-specific hybridization to complementary RNA or DNA targets inside the cell. Once bound, the complex can recruit enzymes that degrade the RNA or prevent protein synthesis. Some oligonucleotides also modify splicing or transcription processes. This targeted interference enables selective gene regulation without affecting unrelated pathways.
Reference
- Klabenkova, K., Fokina, A., & Stetsenko, D. (2021). Chemistry of peptide-oligonucleotide conjugates: A review. Molecules, 26(17), 5420. https://doi.org/10.3390/molecules26175420
- Venkatesan, N., & Kim, B. H. (2006). Peptide conjugates of oligonucleotides: Synthesis and applications. Chemical Reviews, 106(9), 3712–3761. https://doi.org/10.1021/cr0502448
- Malinowska, A. L., Huynh, H. L., & Bose, S. (2024). Peptide-oligonucleotide conjugation: Chemistry and therapeutic applications. Current Issues in Molecular Biology, 46(10), 11031–11047. https://doi.org/10.3390/cimb46100655