mPEG-b-PLGA
Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (mPEG-b-PLGA) – Advanced Biodegradable Block Copolymers for Drug Delivery
ResolveMass Laboratories Inc. offers high-purity Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (mPEG-b-PLGA) block copolymers designed specifically for complex generic formulations, long-acting injectables, nanoparticle systems, and controlled-release drug delivery programs.
mPEG-b-PLGA is a biodegradable amphiphilic block copolymer in which a hydrophilic mPEG block is covalently linked to a hydrophobic PLGA block. This architecture enables self-assembly into micelles, nanoparticles, and depot-forming matrices ideal for encapsulation of small molecules, peptides, biologics, and nucleic-acid-based drugs.
Key Features & Technical Advantages
1. Controlled Block Lengths and Composition
We provide mPEG-b-PLGA with customizable molecular weights, lactide:glycolide ratios, and PEG block lengths to achieve precise:
Release kinetics
Polymer degradation profiles
Hydrophilic–hydrophobic balance
Drug loading efficiency
2. High Purity for Complex Generic and NDA Enabling Studies
Each lot undergoes advanced QC, including:
GPC/SEC with universal calibration for molecular weight and polydispersity
¹H/¹³C NMR for block ratio and end-group analysis
FTIR for structural confirmation
HRMS (if required for research-grade polymers)
These analytical controls make our mPEG-b-PLGA suitable for regulatory-driven formulation research, ANDA/NDA enabling work, and CMC development.
3. Excellent Biocompatibility & Predictable Biodegradability
PLGA is a clinically established biodegradable polymer, and PEG provides:
Improved aqueous dispersibility
Reduced opsonization and protein adsorption
Lower aggregation tendency for nanoparticle systems
This results in more stable formulations and enhanced pharmacokinetic profiles.
Applications
✔ Long-Acting Injectable (LAI) Formulations
mPEG-b-PLGA forms stable depots and microparticles suitable for:
Peptides (GLP-1 analogs, octreotide, leuprolide)
Small molecules
Oligonucleotide delivery
✔ Nanoparticles & Micelles for Complex Generic Drug Development
Ideal for:
Solubility enhancement
Targeted delivery
Controlled release of hydrophobic APIs
✔ Biologics, mRNA, and Oligonucleotide Delivery
The amphiphilic structure enables encapsulation of sensitive biomolecules with improved stability.
✔ Custom Polymer Design for Novel Drug Delivery Projects
ResolveMass Laboratories provides custom synthesis of mPEG-b-PLGA with:
Tailored molecular weights (1–50 kDa PEG blocks; 5–200 kDa PLGA blocks)
Precise L:G ratios (50:50, 75:25, 65:35, and fully customized)
Terminal functionalization options (COOH, NH₂, azide, maleimide)
Why Choose ResolveMass Laboratories Inc.?
✔ Expertise in Biodegradable Polymers
We specialize in PLGA, PLA, PCL, PEG-block copolymers, and custom polymer synthesis supporting complex formulation and delivery challenges.
✔ Advanced Characterization Capabilities
Our in-house analytical arsenal includes:
HRMS and LC-MS/MS
MALDI-TOF for polymer end-group verification
GPC (triple detection)
NMR structural elucidation
✔ Formulation-Oriented Customization
Manufactured specifically for pharma R&D, complex generics, depot systems, and early-stage development.
Available Grades
Research grade
High-purity grade for formulation development
Custom synthesis tailored to specific projects
Request Custom mPEG-b-PLGA Specifications
If you require a specific block length, L:G ratio, PEG molecular weight, or functionalized terminal groups, our chemistry team can design and synthesize the exact polymer your CMC or formulation project requires.