PLGA-PEG-PLGA
PLGA-PEG-PLGA Triblock Copolymers – Biodegradable Thermo-Responsive Polymers for Advanced Drug Delivery
ResolveMass Laboratories Inc. provides high-purity PLGA-PEG-PLGA (poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)) triblock copolymers engineered for long-acting injectable systems, in-situ forming hydrogels, nanoparticle delivery platforms, and complex generic drug development.
This ABA triblock architecture combines:
Hydrophobic PLGA end blocks
A hydrophilic PEG mid-block
The resulting polymer exhibits thermo-responsive gelation, forming a sol at low temperature and transitioning into a stable gel at physiological temperature—ideal for sustained release depots and injectable gel formulations.
Key Features & Technical Advantages
1. Thermo-Responsive Sol-Gel Transition
PLGA-PEG-PLGA triblock copolymers undergo reversible sol-to-gel transition:
Injectable as a low-viscosity solution
Forms an in-situ gel at 35–37°C
Enables weeks to months of sustained drug release
We can tune the gelation temperature by adjusting:
PEG molecular weight
PLGA block length
Lactide:glycolide ratio
2. Customizable Molecular Weight & Composition
Available with fully customizable:
PEG block lengths (1–20 kDa)
PLGA block molecular weights (2–60 kDa each)
L:G ratios (50:50, 65:35, 75:25, or customer-specified)
This level of control allows optimized:
Depot formation
Release kinetics
Biodegradation rate
Solubility and mechanical properties
3. High-Purity Polymer for Controlled Release Formulation
Each batch is characterized using:
GPC/SEC with universal calibration
¹H/¹³C NMR for block identification and composition
FTIR for structural confirmation
DSC and TGA (optional) for thermal properties
MALDI-TOF or HRMS for end-group analysis (upon request)
These QC parameters support projects ranging from ANDA complex injectables to NDA enabling studies.
Applications
✔ Long-Acting Injectable Depots (In-Situ Gel Systems)
PLGA-PEG-PLGA forms biodegradable hydrogels suitable for:
Peptides (GLP-1 analogs, leuprolide, octreotide)
Proteins and biologics
Oligonucleotides
Hydrophobic and hydrophilic APIs
✔ Solubility Enhancement & Nanoparticle Formation
This amphiphilic architecture enables:
Self-assembly into micelles and nanoparticles
Enhanced aqueous compatibility
Improved pharmacokinetics
✔ Complex Generic Drug Delivery and 505(b)(2) Programs
Ideal for research involving:
Injectable gel depots
Biodegradable implants
Modified-release formulations for difficult APIs
✔ Custom Polymer Design for Novel Pharma R&D
We offer fully tailored polymer engineering for:
Thermo-responsive injectable gels
High-drug-loading micelles
Stabilization of sensitive biomolecules
Why Choose ResolveMass Laboratories Inc.?
✔ Specialized Expertise in Biodegradable Block Copolymers
Our team routinely synthesizes:
PLGA-PEG-PLGA
mPEG-PLGA
PLA-PEG-PLA
PCL-PEG-PCL
Fully customized block copolymers
✔ Advanced Characterization Infrastructure
Including:
Triple-detector GPC
HRMS & LC-MS/MS
MALDI-TOF
DSC/TGA
High-field NMR
✔ Formulation-Driven Polymer Engineering
We focus on polymer performance needed for CMC, complex generics, biosimilar depot systems, and novel delivery platforms.
Available Grades
Standard research grade
High-purity grade for formulation development
Custom synthesized to target molecular weight & gelation profile
Request Custom PLGA-PEG-PLGA Specifications
Our chemistry team can design triblock copolymers with precise molecular architecture, tailored for your long-acting injectable or controlled-release innovation.