1,3-Propane-d6-diamine | CAS 90375-98-7

OVERVIEW  of  1,3-Propane-d6-diamine | CAS 90375-98-7

1,3-Propane-d₆-diamine (CAS 90375-98-7) is a fully deuterated analog of 1,3-propanediamine, a simple aliphatic diamine widely used in organic synthesis and analytical chemistry. In this compound, all six hydrogen atoms on the carbon backbone are replaced by deuterium, resulting in a highly enriched isotopic molecule that is ideal for mass spectrometry (MS), nuclear magnetic resonance (NMR), and isotope tracer studies. This deuterated version is an important reagent for mechanistic investigations, labeling experiments, and the preparation of deuterium-labeled materials.

CHEMICAL INFORMATION

• Name: 1,3-Propane-d₆-diamine

• Molecular Formula: C₃D₆N₂

• Molecular Weight: 80.16 g/mol

• CAS Number: 90375-98-7

• Isotopic Enrichment: ≥98 atom % D

• Chemical Class: Deuterated aliphatic diamine

• Solubility: Miscible with water, ethanol, and most polar solvents

APPLICATIONS  of  1,3-Propane-d6-diamine | CAS 90375-98-7

• NMR Spectroscopy:
  1,3-Propane-d₆-diamine is used as a deuterium-labeled standard in NMR studies to reduce proton interference and improve resolution. The deuteration suppresses background proton signals, enabling clearer observation of adjacent or bound chemical groups.

• Mass Spectrometry (MS):
  Serves as a quantitative internal standard or reference compound for MS analyses involving amines and related nitrogen-containing compounds. The isotopic shift between the labeled and unlabeled analogs allows accurate detection and quantitation.

• Isotopic Tracing and Mechanistic Studies:
  Employed in kinetic isotope effect investigations and reaction pathway studies, helping to identify hydrogen exchange processes and molecular rearrangements.

• Synthesis of Labeled Compounds:
  Acts as a precursor for the preparation of deuterated pharmaceutical intermediates, coordination complexes, and polymeric materials that require isotope incorporation for structural or metabolic analysis.

ADVANTAGES  of  1,3-Propane-d6-diamine | CAS 90375-98-7

• High deuterium enrichment ensures analytical precision.

• Excellent chemical and thermal stability under laboratory conditions.

• Provides reliable mass differentiation for isotope-labeled studies.

• Compatible with aqueous and organic systems.

• Non-corrosive and easy to handle compared to other diamine derivatives.

HANDLING AND SAFETY

• Handling Precautions: Use only in well-ventilated areas. Avoid contact with skin, eyes, and mucous membranes.

• Protective Equipment: Laboratory gloves, protective eyewear, and appropriate clothing should be worn during handling.

• Storage: Keep container tightly closed in a cool, dry place. Store under inert gas to prevent oxidation or moisture absorption.

• Stability: Stable under normal laboratory conditions but hygroscopic in nature.

• Disposal: Dispose of in accordance with institutional and local environmental regulations for amine-containing chemicals.

SUMMARY
1,3-Propane-d₆-diamine (CAS 90375-98-7) is a highly deuterated diamine that serves as a valuable isotopic reagent for NMR and MS analysis, isotope tracing, and mechanistic chemistry. Its structural simplicity, stability, and high isotopic purity make it a versatile tool in research and industrial laboratories, particularly in the development and study of deuterium-labeled molecular systems.