1,4-Butane-d8-diamine 2 HCl | CAS 284665-22-1

OVERVIEW  of  1,4-Butane-d8-diamine 2 HCl | CAS 284665-22-1

1,4-Butane-d₈-diamine·2HCl (CAS 284665-22-1) is a fully deuterated diamine derivative presented as its dihydrochloride salt. This compound features eight deuterium atoms replacing all hydrogen atoms along the butane backbone, providing a stable isotopic label for analytical and synthetic applications. Its deuterated structure is chemically equivalent to native 1,4-butanediamine (putrescine), making it ideal for use as an isotopic internal standard, metabolic tracer, and research reagent in various biochemical and pharmaceutical studies.

CHEMICAL INFORMATION

• Name: 1,4-Butane-d₈-diamine·2HCl

• Molecular Formula: C₄D₁₂N₂·2HCl

• Molecular Weight: 169.12 g/mol

• CAS Number: 284665-22-1

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated aliphatic diamine (dihydrochloride salt)

• Melting Point: ~260 °C (decomposition)

APPLICATIONS  of  1,4-Butane-d8-diamine 2 HCl | CAS 284665-22-1

• Mass Spectrometry (MS):
  Used as an internal standard for quantitative MS analysis of putrescine and related diamines. The deuterium labeling allows accurate isotope differentiation for metabolic profiling and biogenic amine quantification in biological samples.

• NMR Spectroscopy:
  Provides a deuterium-labeled reference that reduces spectral interference from proton signals, enhancing signal clarity and enabling detailed structural analysis.

• Metabolomic and Pharmacokinetic Studies:
  Ideal for tracing metabolic pathways involving polyamines and diamines. Enables accurate determination of uptake, distribution, and transformation of putrescine-like molecules in biological systems.

• Isotopic Labeling and Mechanistic Research:
  The compound is used in enzyme mechanism studies and hydrogen–deuterium exchange experiments to elucidate biochemical reaction mechanisms and bond cleavage pathways.

• Synthetic Chemistry:
  Serves as a building block for the preparation of deuterated polymers, pharmaceuticals, and analytical standards where isotopic labeling is required for quality control and molecular tracing.

ADVANTAGES  of  1,4-Butane-d8-diamine 2 HCl | CAS 284665-22-1

• Fully deuterated (eight deuterium atoms) for maximum isotopic labeling.

• Dihydrochloride salt form enhances stability and solubility.

• Non-radioactive and stable under normal laboratory conditions.

• Excellent isotopic tracer for quantitative biochemical and pharmacological research.

• Chemically equivalent to native 1,4-butanediamine, allowing direct comparative studies.

HANDLING AND SAFETY

• Handling: Avoid contact with skin, eyes, and clothing. Use with adequate ventilation.

• Protective Equipment: Wear appropriate gloves, lab coat, and protective eyewear.

• Storage: Store in a tightly sealed container under inert atmosphere or desiccation conditions.

• Stability: Hygroscopic; protect from moisture. Stable when stored properly.

• Disposal: Dispose of in accordance with institutional and local chemical waste regulations.

SUMMARY
1,4-Butane-d₈-diamine·2HCl (CAS 284665-22-1) is a high-purity, fully deuterated diamine salt widely employed in mass spectrometry, NMR, isotopic labeling, and biochemical research. Its high deuterium enrichment, enhanced solubility, and chemical stability make it an excellent standard for quantitative analysis and a valuable tool for mechanistic and metabolic investigations.