17β-Estradiol Sulphate Sodium Salt | CAS 4999-79-5

CAS Number: 4999-79-5
Synonyms: Estradiol Sulphate Sodium Salt, 17β-Estradiol 3-O-Sulfate Sodium Salt, E2S Sodium Salt
Molecular Formula: C₁₈H₂₃NaO₅S
Molecular Weight: 374.43 g/mol

Product Overview

17β-Estradiol Sulphate Sodium Salt (CAS 4999-79-5) is a sulfated metabolite of 17β-estradiol and an important analytical reference compound widely used in endocrinology, steroid hormone research, bioanalysis, metabolomics, and pharmaceutical development. As one of the primary circulating conjugated estrogens, it serves as a valuable biomarker for investigating estrogen metabolism, steroid biosynthesis, hormone transport, and enzymatic deconjugation pathways.

The sodium salt form offers improved aqueous solubility compared to the free sulfate, making it suitable for analytical method development, calibration, quality control, and LC-MS/MS applications. Researchers commonly utilize this compound as a certified reference material during quantitative analysis of estrogen metabolites in biological matrices such as plasma, serum, urine, and tissue samples.

ResolveMass Laboratories Inc. supplies high-quality research chemicals and analytical reference standards that support pharmaceutical, biotechnology, clinical research, toxicology, and academic laboratories. Every batch is manufactured under stringent quality standards to ensure excellent purity, consistency, and reproducibility for research applications.

Applications:

17β-Estradiol Sulphate Sodium Salt is extensively used in numerous research and analytical fields, including:

• LC-MS/MS method development and validation
• Steroid hormone profiling and metabolomics
• Endocrinology and reproductive biology research
• Estrogen metabolism investigations
• Clinical biomarker studies
• Bioanalytical assay development
• Pharmacokinetic and pharmacodynamic studies
• Pharmaceutical quality control
• Drug metabolism and biotransformation studies
• Reference standard for quantitative analytical methods

The compound is particularly valuable in laboratories performing highly sensitive hormone analysis where accurate identification and quantification of estrogen metabolites are essential.

Importance in Steroid Metabolism Research

Estradiol sulfate represents an important conjugated storage and transport form of endogenous estrogen. Sulfation is a major Phase II metabolic pathway that regulates estrogen activity, enhances water solubility, and facilitates transport through the bloodstream. Sulfatase enzymes can subsequently regenerate biologically active estradiol from estradiol sulfate in various tissues, making this metabolite highly significant in studies involving hormone regulation and tissue-specific estrogen activation.

Researchers studying endocrine physiology, hormone-related disorders, reproductive health, and hormone-dependent cancers frequently analyze estradiol sulfate concentrations to better understand estrogen homeostasis and metabolic pathways.

Analytical Applications

Modern analytical laboratories increasingly rely on 17β-Estradiol Sulphate Sodium Salt for developing robust quantitative assays using advanced instrumentation such as:

• Liquid Chromatography-Mass Spectrometry (LC-MS/MS)
• High-Resolution Mass Spectrometry (HRMS)
• UHPLC-MS/MS
• Triple Quadrupole LC-MS
• Tandem Mass Spectrometry
• HPLC with appropriate detection systems

Because endogenous estrogen metabolites are often present at very low concentrations, highly purified analytical standards are essential for calibration curve preparation, system suitability testing, method validation, accuracy assessment, precision studies, and long-term analytical reproducibility.

Pharmaceutical and Clinical Research

In pharmaceutical research, this reference material supports studies involving:

• Steroid hormone therapeutics
• Women’s health research
• Endocrine disorder investigations
• Hormone replacement therapy research
• Drug metabolism studies
• Biomarker discovery
• Clinical bioanalysis
• Translational medicine

It is also valuable during preclinical and clinical investigations where endogenous estrogen metabolites must be accurately quantified to evaluate pharmacological effects or disease progression.

Quality and Reliability

ResolveMass Laboratories Inc. is committed to supplying research chemicals that meet the demanding requirements of pharmaceutical, biotechnology, CRO, and academic laboratories. Each batch undergoes rigorous quality evaluation to ensure consistent identity, purity, and analytical performance suitable for research applications.

Researchers can expect:

• High chemical purity
• Batch-to-batch consistency
• Reliable analytical performance
• Suitable for research and laboratory use
• Comprehensive product documentation
• Secure packaging to maintain product integrity

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. supports researchers worldwide with premium analytical reference standards and specialized laboratory solutions for pharmaceutical and life science applications. Our expertise in analytical chemistry, mass spectrometry, bioanalysis, and reference standard characterization enables researchers to achieve accurate, reproducible, and regulatory-compliant analytical results.

Whether you are developing a new bioanalytical assay, validating an LC-MS/MS method, investigating steroid metabolism, or performing quantitative hormone analysis, ResolveMass provides dependable reference materials backed by scientific expertise and quality assurance.

For additional information regarding 17β-Estradiol Sulphate Sodium Salt (CAS 4999-79-5), including technical specifications, certificates of analysis, availability, or custom analytical support, please contact the scientific team at ResolveMass Laboratories Inc.

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