2-Aminopyridine-d6 | CAS 203784-57-0

OVERVIEW
2-Aminopyridine-d₆ is a fully deuterated heteroaromatic amine in which all six hydrogen atoms of the pyridine ring are replaced by deuterium. This isotopically labeled analogue of 2-aminopyridine (C₅H₆N₂) offers a molecular mass increase of +6 Da, providing a valuable tool for researchers engaged in isotope labeling, analytical calibration, and mechanistic investigations.

Because the introduction of deuterium atoms does not significantly alter the chemical reactivity or physical properties of the parent compound, 2-Aminopyridine-d₆ behaves identically to its non-deuterated counterpart in most chemical and biological systems. Its stability, isotopic precision, and clean spectroscopic profile make it a preferred standard in mass spectrometry (MS), nuclear magnetic resonance (NMR) studies, and pharmaceutical research.

ResolveMass Laboratories Inc. synthesizes and supplies 2-Aminopyridine-d₆ with high isotopic enrichment and stringent purity control, ensuring reliability, reproducibility, and consistent analytical performance across a wide range of scientific applications.

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CHEMICAL INFORMATION

• Name: 2-Aminopyridine-d₆

• Molecular Formula: C₅D₆N₂

• Molecular Weight: 100.19 g/mol

• CAS Number: 203784-57-0

• Isotopic Enrichment: ≥98 atom % D

• Stability: Stable under normal storage conditions; sensitive to strong oxidizing agents

The compound’s deuterated pyridine ring provides a stable isotopic signature while maintaining identical electronic and structural characteristics, making it ideal for kinetic and mechanistic isotope effect studies.

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APPLICATIONS  of  2-Aminopyridine-d6 | CAS 203784-57-0

1. Internal Standard for Mass Spectrometry (MS):
2-Aminopyridine-d₆ is extensively employed as an internal standard for quantitative analysis in LC-MS and GC-MS. The +6 Da mass shift allows for precise differentiation from unlabeled analogues, ensuring accuracy in isotope dilution assays and trace analysis of pyridine derivatives.

2. NMR Spectroscopy and Spectral Simplification:
The deuteration of the aromatic ring reduces proton signal interference in ^1H NMR spectra, simplifying spectral interpretation and enhancing the visibility of exchangeable protons and functional groups. It also serves as a reference compound for ^2H NMR studies in heterocyclic systems.

3. Synthesis of Deuterated Pharmaceuticals and Ligands:
Due to the presence of an amino group and a nitrogen-containing ring, 2-Aminopyridine-d₆ serves as a versatile intermediate in the synthesis of deuterated drugs, agrochemicals, and heterocyclic ligands used in medicinal chemistry and catalysis research.

4. Mechanistic and Kinetic Isotope Effect (KIE) Studies:
In mechanistic chemistry, it is used to evaluate isotopic substitution effects on reaction rates, particularly in hydrogen-deuterium exchange (HDX) and substitution reactions involving aromatic amines and pyridine derivatives.

5. Isotopic Tracing in Metabolic and Environmental Studies:
Researchers use 2-Aminopyridine-d₆ as a tracer to monitor the behavior of nitrogen-containing heterocycles in biochemical and environmental systems. Its stable deuterium labeling provides clear differentiation in isotopic ratio measurements and compound tracking.

6. Analytical Instrument Calibration:
Its defined isotopic mass and chemical stability make it an ideal calibration standard for high-resolution MS instruments, ensuring accurate mass assignments and reproducible isotope ratio analyses.

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ADVANTAGES  of  2-Aminopyridine-d6 | CAS 203784-57-0

• High Isotopic Enrichment (≥98 atom % D): Ensures reliable isotopic labeling and analytical precision.

• Distinct Mass Shift (+6 Da): Facilitates unambiguous detection in MS-based assays.

• Chemical Equivalence to 2-Aminopyridine: Maintains identical reactivity and physicochemical properties.

• Enhanced Spectral Clarity in NMR: Minimizes proton interference for accurate signal resolution.

• Stable and Non-Toxic: Safe and durable for long-term laboratory use.

• Versatile in Research Applications: Applicable in synthetic chemistry, spectroscopy, and isotope tracing studies.

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HANDLING

• Handle in a well-ventilated area or fume hood to minimize inhalation exposure.

• Avoid contact with skin, eyes, and clothing.

• Use appropriate personal protective equipment (gloves, goggles, and lab coat).

• Prevent contact with strong oxidizing or acidic agents.

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QUALITY & ANALYTICAL CHARACTERIZATION
At ResolveMass Laboratories Inc., each batch of 2-Aminopyridine-d₆ undergoes rigorous testing to confirm isotopic integrity, chemical purity, and consistency.

Analytical Verification Includes:

• Mass Spectrometry (MS): Confirms +6 Da isotopic mass shift and molecular identity.

• NMR Spectroscopy (^1H, ^2H, ^13C): Validates complete deuteration and structural conformation.

• Infrared Spectroscopy (IR): Identifies characteristic N–H and C–D vibrational bands.

• Chromatographic Purity (HPLC/GC): Ensures minimal impurities and consistent retention times.

Every product is accompanied by a Certificate of Analysis (COA) and Safety Data Sheet (SDS) verifying isotopic enrichment, analytical results, and regulatory compliance for laboratory and industrial research use.

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SUMMARY
2-Aminopyridine-d₆ (CAS 203784-57-0) is a high-purity, fully deuterated aromatic amine ideal for isotope labeling, NMR reference, and analytical calibration applications. Its chemical stability, isotopic precision, and functional reactivity make it indispensable for kinetic isotope studies, spectroscopic characterization, and the synthesis of deuterium-labeled pharmaceuticals and ligands.

Manufactured and quality-verified by ResolveMass Laboratories Inc., 2-Aminopyridine-d₆ offers superior isotopic enrichment, reproducibility, and reliability for advanced scientific research in organic, analytical, and physical chemistry.