2-Methylpyrazine-d6 | CAS 1219804-84-8

OVERVIEW  of  2-Methylpyrazine-d6 | CAS 1219804-84-8

2-Methylpyrazine-d₆ (CAS 1219804-84-8) is a fully deuterated analog of 2-methylpyrazine, a heteroaromatic compound containing both nitrogen and deuterium atoms. The incorporation of six deuterium atoms makes this compound ideal for use in isotope labeling, mass spectrometry (MS), and nuclear magnetic resonance (NMR) studies. It retains the same electronic and chemical characteristics as non-deuterated 2-methylpyrazine, allowing researchers to use it for quantitative analysis, metabolic tracking, and mechanistic investigations in organic and pharmaceutical research.

CHEMICAL INFORMATION

• Name: 2-Methylpyrazine-d₆

• Molecular Formula: C₅D₆N₂

• Molecular Weight: 100.15 g/mol

• CAS Number: 1219804-84-8

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated heterocyclic aromatic compound

• Solubility: Soluble in organic solvents such as ethanol, methanol, ether, and chloroform

APPLICATIONS  of  2-Methylpyrazine-d6 | CAS 1219804-84-8

• Mass Spectrometry (MS):
  Used as an internal standard or reference compound for quantifying 2-methylpyrazine and related heterocycles in analytical and environmental samples.

• Nuclear Magnetic Resonance (NMR):
  The deuterium substitution minimizes proton signal interference, making it a useful reference standard or solvent additive in NMR spectroscopy.

• Metabolic and Pharmacokinetic Studies:
  Acts as a stable isotope tracer to monitor the biotransformation and fate of pyrazine derivatives in biological systems.

• Synthetic Chemistry:
  Serves as a deuterium-labeled building block for the synthesis of isotopically labeled pharmaceuticals and fine chemicals.

• Food and Flavor Research:
  2-Methylpyrazine derivatives contribute to roasted and nutty flavor notes; the deuterated analog aids in flavor pathway tracing and analysis.

ADVANTAGES  of  2-Methylpyrazine-d6 | CAS 1219804-84-8

• High deuterium incorporation ensures superior isotopic resolution in analytical detection.

• Chemically stable and non-radioactive.

• Structurally equivalent to native 2-methylpyrazine for direct comparative studies.

• Enhances spectral resolution in both MS and NMR applications.

• Facilitates precise quantification in isotope dilution experiments.

HANDLING AND SAFETY

• Handling: Avoid inhalation and contact with skin or eyes. Use under well-ventilated conditions.

• Storage: Keep in a tightly closed container, stored in a cool, dry, and dark place.

• Safety: Mild irritant; standard laboratory PPE (gloves, goggles, lab coat) is recommended.

• Disposal: Dispose of according to local and institutional regulations for organic solvents and deuterated compounds.

SUMMARY
2-Methylpyrazine-d₆ (CAS 1219804-84-8) is a deuterium-labeled heterocyclic compound widely used in analytical, pharmaceutical, and flavor chemistry research. Its high isotopic purity and stability make it invaluable for NMR, MS quantification, and isotope tracing studies, ensuring precise and reproducible analytical outcomes across a range of scientific disciplines.