2,3-Pyridine-d3-dicarboxylic Acid | CAS 138946-42-6

OVERVIEW
2,3-Pyridine-d₃-dicarboxylic acid is a deuterium-labeled analog of pyridine-2,3-dicarboxylic acid, also known as quinolinic acid, an important metabolite in the kynurenine pathway of tryptophan degradation. In this labeled compound, three hydrogen atoms of the pyridine ring are substituted with deuterium, providing a +3 Da isotopic mass shift while retaining the same molecular structure and reactivity as the non-deuterated form.

This compound is particularly useful in metabolic tracing, biochemical analysis, and mass spectrometric quantification of quinolinic acid in biological samples. Due to its chemical and biological equivalence, 2,3-pyridine-d₃-dicarboxylic acid serves as an ideal internal standard for the determination of endogenous quinolinic acid levels in neurochemical and clinical studies related to neuroinflammation, neurodegenerative disorders, and metabolic pathway analysis.

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CHEMICAL INFORMATION

• Name: 2,3-Pyridine-d₃-dicarboxylic acid

• Molecular Formula: C₇D₃NO₄

• Molecular Weight: 170.14 g/mol

• CAS Number: 138946-42-6

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated heteroaromatic dicarboxylic acid; stable isotope-labeled pyridine derivative

• Solubility: Soluble in water and polar organic solvents (ethanol, methanol)

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APPLICATIONS  of  2,3-Pyridine-d3-dicarboxylic Acid | CAS 138946-42-6

• Metabolic and Neurochemical Research:
  2,3-Pyridine-d₃-dicarboxylic acid is widely used as a stable isotope-labeled internal standard in the study of the kynurenine pathway of tryptophan metabolism. It facilitates precise quantification of quinolinic acid in biological fluids and tissues using LC-MS/MS and GC-MS techniques.

• Analytical Chemistry and Mass Spectrometry:
  Serves as an internal standard for accurate quantification of quinolinic acid and related metabolites in metabolic and pharmacokinetic analyses. The deuterium substitution ensures reliable isotopic distinction without affecting chromatographic or spectrometric behavior.

• Biochemical Pathway Analysis:
  Utilized in tracer experiments to monitor metabolic fluxes, enzyme kinetics, and isotopic labeling in tryptophan catabolism studies.

• Pharmaceutical and Clinical Research:
  Plays an important role in drug discovery and biomarker quantification related to neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, where quinolinic acid serves as a key neurotoxin marker.

• Quality Control and Calibration Studies:
  Employed as a reference material in analytical laboratories for calibrating assays that detect quinolinic acid and its derivatives in plasma, cerebrospinal fluid, and tissue extracts.

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ADVANTAGES  of  2,3-Pyridine-d3-dicarboxylic Acid | CAS 138946-42-6

• High isotopic enrichment ensures clear mass spectrometric resolution.

• Chemically identical to quinolinic acid, ensuring method accuracy and reproducibility.

• Non-radioactive and safe for handling, making it suitable for biochemical and clinical studies.

• Enhances precision and reliability in isotope dilution and trace analysis.

• Useful for both quantitative and qualitative research on metabolic and neurochemical pathways.

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HANDLING

• Hazards: Low-toxicity compound; may cause mild irritation upon prolonged contact or inhalation.

• Precautions: Use standard laboratory protective measures—gloves, safety glasses, and lab coat. Avoid inhaling dust and contact with eyes.

• Storage: Keep container tightly closed, stored in a cool, dry location away from direct sunlight and moisture.

• Disposal: Dispose of according to local chemical waste regulations; avoid release into the environment.

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QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Analytical Verification: Confirmed by ¹H NMR, ²H NMR, IR, and LC-MS analysis

• Appearance: White crystalline or powdery solid

• COA Availability: Supplied with batch-specific Certificate of Analysis verifying isotopic and chemical purity

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SUMMARY
2,3-Pyridine-d₃-dicarboxylic acid (CAS 138946-42-6) is a highly pure, stable isotope-labeled analog of quinolinic acid used extensively in neurochemical and metabolic studies. Its deuterium substitution allows for precise quantification and tracing of quinolinic acid in complex biological matrices. This compound plays a vital role in analytical chemistry, neurobiological research, and mass spectrometry, serving as an indispensable tool for elucidating metabolic pathways and studying disease-related biomarkers.

 

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