4-Methoxyphenol-2,3,5,6-d4,OD | CAS 159839-23-3

OVERVIEW  of  4-Methoxyphenol-2,3,5,6-d4,OD | CAS 159839-23-3

4-Methoxyphenol-2,3,5,6-d4,OD (CAS 159839-23-3) is a selectively deuterium-labeled phenolic compound designed for high-precision analytical, mechanistic, and kinetic studies. With four deuterium atoms incorporated into the aromatic ring and an additional deuterium on the phenolic hydroxyl group (OD), this molecule provides exceptional isotopic stability and predictable mass shifts, making it highly valuable in quantitative LC-MS, GC-MS, and NMR applications. Its enhanced structural stability, minimized hydrogen–deuterium exchange, and high isotopic purity support accurate internal standardization, metabolic profiling, and environmental exposure assessment.

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CHEMICAL INFORMATION

• Chemical Name: 4-Methoxyphenol-2,3,5,6-d4,OD

• CAS Number: 159839-23-3

• Molecular Formula: C₇D₅DO₂OCH₃

• Isotopic Enrichment: ≥98% D

• Functional Groups: Deuterated phenolic OH (OD), methoxy group (–OCH₃)

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APPLICATIONS  of  4-Methoxyphenol-2,3,5,6-d4,OD | CAS 159839-23-3

 

1. Internal Standard for Quantitative LC-MS and GC-MS
4-Methoxyphenol-d5 provides excellent mass separation and ionization behavior, making it a preferred internal standard for phenolic antioxidant quantification, environmental residue analysis, and biological sample workflows.

2. Environmental Contaminant and Oxidative Stress Marker Studies
Because 4-methoxyphenol is widely monitored in environmental and industrial contexts, its deuterated variant is valuable for method development, method validation, and precision quantification in air, soil, wastewater, and biological fluids.

3. NMR Spectroscopy and Mechanistic Studies
The deuterium pattern supports enhanced signal suppression, allowing clearer observation of non-deuterated partners in reaction monitoring, enzymatic pathways, and oxidation–reduction mechanisms involving phenolic compounds.

4. Pharmaceutical and Cosmetic Research
4-Methoxyphenol is relevant in skin-lightening formulations and antioxidant systems. The deuterated analog helps track metabolic transformations, photodegradation pathways, and safety evaluations.

5. Stable Isotope Tracing and Reaction Kinetics
The OD label is especially valuable for studying proton-transfer behavior, H/D exchange rates, and the role of phenolic protons in redox activity.

 

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