Albuterol-d3 | CAS 1219798-60-3

OVERVIEW  of  Albuterol-d3 | CAS 1219798-60-3

Albuterol-d₃ (CAS 1219798-60-3) is a stable isotope-labeled analog of albuterol, a widely used β₂-adrenergic receptor agonist employed in the treatment of asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders. In this deuterated compound, three hydrogen atoms are replaced with deuterium, resulting in a +3 Da molecular mass difference while maintaining identical pharmacological and physicochemical properties to the parent compound.

Albuterol-d₃ is primarily used as an internal standard in quantitative mass spectrometry (LC-MS/MS) to measure albuterol and related β₂-agonists in biological matrices such as plasma, serum, urine, or inhalation formulations. Its isotopic labeling ensures analytical accuracy and reproducibility in both pharmacokinetic and bioanalytical studies.

CHEMICAL INFORMATION

• Name: Albuterol-d₃;

• Molecular Formula: C₁₃H₁₆D₃NO₃

• Molecular Weight: 242.33 g/mol

• CAS Number: 1219798-60-3

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: β₂-Adrenergic agonist; deuterated pharmaceutical standard

• Stability: Stable under normal laboratory conditions when stored dry and protected from light

APPLICATIONS  of  Albuterol-d3 | CAS 1219798-60-3

• Bioanalytical Quantification:
  Albuterol-d₃ serves as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS assays for accurate quantification of albuterol levels in biological fluids and pharmaceutical formulations.

• Pharmacokinetic & Metabolic Studies:
  Used to evaluate absorption, distribution, metabolism, and excretion (ADME) profiles of albuterol in preclinical and clinical research settings.

• Clinical & Pharmaceutical Analysis:
  Applied in therapeutic drug monitoring, formulation stability testing, and quality control of albuterol-based inhalers and tablets.

• Toxicology & Exposure Assessment:
  Useful for investigating environmental or occupational exposure to β₂-agonists and verifying compliance in doping control analyses.

• Analytical Method Validation:
  Acts as a reference calibration compound for retention time alignment and signal normalization during LC-MS/MS assay development.

ADVANTAGES  of  Albuterol-d3 | CAS 1219798-60-3

• High isotopic enrichment ensures distinct mass separation from the unlabeled compound.

• Chemically and chromatographically identical to native albuterol, ensuring accurate internal standard performance.

• Non-radioactive, stable, and compatible with all major analytical platforms.

• Improves data precision, reproducibility, and quantitative reliability in pharmacological studies.

HANDLING, STORAGE & SAFETY

• Handling Precautions: Avoid contact with moisture and direct sunlight. Use gloves and protective eyewear when handling.

• Storage: Keep tightly sealed at –20 °C in a dry, inert atmosphere.

• Safety: Non-hazardous under normal laboratory conditions; follow good laboratory practices (GLP).

• Disposal: Dispose of in accordance with institutional and regional guidelines for organic laboratory chemicals.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Form: Solid or crystalline powder

• Analytical Verification: Confirmed by LC-MS and NMR spectroscopy

• Documentation: Supplied with Certificate of Analysis (CoA) verifying isotopic enrichment and purity

SUMMARY
Albuterol-d₃ | CAS 1219798-60-3 is a deuterated reference standard designed for precise quantification of albuterol in analytical and bioanalytical assays. It offers high isotopic enrichment and physicochemical stability, making it an essential tool for pharmacokinetic, clinical, and toxicological studies. Its identical chromatographic behavior to the native drug ensures reliable internal standardization, improving the accuracy and reproducibility of LC-MS/MS-based assays used in drug monitoring and respiratory research.