Bis(2-chloroethyl)-d8-amine HCl | CAS 102092-04-6

OVERVIEW of  Bis(2-chloroethyl)-d8-amine HCl | CAS 102092-04-6

Bis(2-chloroethyl)-d8-amine HCl (CAS 102092-04-6) is a deuterium-labeled analogue of bis(2-chloroethyl)amine hydrochloride, in which eight hydrogen atoms are replaced with deuterium. This isotopically enriched compound is primarily utilized as a stable isotope reference standard in analytical chemistry, toxicology, and pharmaceutical research. The compound’s full deuteration enhances its molecular weight while preserving its chemical and reactive properties, enabling scientists to precisely differentiate and quantify labeled versus unlabeled analogues in mass spectrometric (MS) and nuclear magnetic resonance (NMR) analyses.

Due to its structural similarity to the native compound, Bis(2-chloroethyl)-d8-amine HCl is frequently used in studies related to nitrogen mustard analogues, alkylating agents, and biochemical reaction mechanisms. Its high isotopic purity and reliable stability make it valuable for method validation, tracer experiments, and pharmacokinetic modeling.

---

CHEMICAL INFORMATION

• Name: Bis(2-chloroethyl)-d8-amine hydrochloride

• Molecular Formula: C₄D₈Cl₂NH₂·HCl

• Molecular Weight: 185.52 g/mol

• CAS Number: 102092-04-6

• Isotopic Labeling: Eight deuterium atoms (≥ 98 atom % D)

• Chemical Class: Deuterated aliphatic amine hydrochloride

• Stability: Stable under standard laboratory conditions

---

APPLICATIONS  of  Bis(2-chloroethyl)-d8-amine HCl | CAS 102092-04-6

• Mass Spectrometry (MS):
  Serves as a stable isotope internal standard for quantifying bis(2-chloroethyl)amine and its derivatives in complex matrices.

• NMR Spectroscopy:
  Used as an isotopically labeled reference compound for detailed structure elucidation and chemical shift calibration in ¹H and ²H NMR studies.

• Pharmaceutical and Toxicological Research:
  Valuable for mechanistic and metabolic investigations involving alkylating agents, including nitrogen mustard analogues, to study their biological reactivity and degradation pathways.

• Analytical Chemistry:
  Utilized for calibration and validation of analytical methods, ensuring high accuracy in isotopic quantification and trace analysis.

• Kinetic and Mechanistic Studies:
  Employed to trace isotopic substitution effects and to model reaction mechanisms in biochemical and organic transformations involving chloroethylamine structures.

---

ADVANTAGES  of  Bis(2-chloroethyl)-d8-amine HCl | CAS 102092-04-6

• High isotopic enrichment (≥ 98 atom % D) ensuring excellent isotopic resolution.

• Chemically identical to the unlabeled analogue, allowing for direct comparative analysis.

• Provides enhanced precision and reproducibility in quantitative mass spectrometric studies.

• Non-radioactive, chemically stable, and easy to handle in standard laboratory settings.

• Suitable for use as a standard, tracer, or synthetic intermediate in research and industrial applications.

---

HANDLING, STORAGE & SAFETY

• Handling: Handle with care under controlled laboratory conditions; avoid contact with moisture or open air.

• Storage: Store in a cool, dry, and well-ventilated place at 2–8 °C.

• Safety: May cause irritation to the skin, eyes, or respiratory tract upon direct contact. Use gloves, eye protection, and laboratory clothing.

• Disposal: Dispose of according to institutional and local chemical waste disposal regulations.

---

QUALITY & SPECIFICATION

• Purity: ≥ 98 % (chemical)

• Isotopic Enrichment: ≥ 98 atom % D

• Analytical Verification: Characterized by ¹H NMR (absence of proton signals), ²H NMR, IR spectroscopy, and GC–MS

• Documentation: Certificate of Analysis (CoA) and Safety Data Sheet (SDS) available upon request

---

SUMMARY
Bis(2-chloroethyl)-d8-amine HCl (CAS 102092-04-6) is a high-purity, isotopically labeled compound widely used in analytical, pharmaceutical, and toxicological research. Its stable deuterium incorporation allows for accurate isotopic tracing, precise quantification, and method calibration in MS and NMR applications. With its reliability, stability, and versatility, this compound serves as an essential tool for scientists investigating the chemical, biological, and kinetic behavior of chloroethylamine derivatives and related alkylating agents.

 

Learn more about,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 

How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 

How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 

Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 

Custom Synthesis of Deuterated Chemicals