Bis(2-hydroxyethyl)-d8-amine | CAS 103691-51-6

OVERVIEW  of  Bis(2-hydroxyethyl)-d8-amine | CAS 103691-51-6
Bis(2-hydroxyethyl)-d8-amine (CAS 103691-51-6) is the deuterated form of diethanolamine, where all eight exchangeable hydrogen atoms are replaced by deuterium. This isotopically labeled compound is widely utilized in mass spectrometry (MS), nuclear magnetic resonance (NMR), and metabolic tracer studies to distinguish between labeled and unlabeled analogs of diethanolamine. It exhibits identical chemical reactivity to its non-deuterated counterpart, making it ideal for use as an internal standard or analytical reference compound.

CHEMICAL INFORMATION

• Name: Bis(2-hydroxyethyl)-d8-amine

• Molecular Formula: C₄D₈NO₂

• Molecular Weight: 113.19 g/mol

• CAS Number: 103691-51-6

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated alkanolamine

• Solubility: Completely miscible with water and polar organic solvents

APPLICATIONS  of  Bis(2-hydroxyethyl)-d8-amine | CAS 103691-51-6

• Mass Spectrometry (MS):
  Used as an internal standard for the quantitative determination of diethanolamine and its derivatives in biological or environmental samples.

• NMR Spectroscopy:
  Serves as a deuterated reference compound for studying proton exchange reactions and structural conformations in alkanolamine systems.

• Biochemical & Pharmaceutical Research:
  Employed as a stable isotope tracer in metabolism and pharmacokinetic studies to follow the biochemical fate of diethanolamine.

• Analytical Chemistry:
  Utilized in method development, calibration, and isotopic dilution analysis for high-precision measurements.

ADVANTAGES  of  Bis(2-hydroxyethyl)-d8-amine | CAS 103691-51-6

• High isotopic purity (≥ 98 atom % D) ensures precise mass distinction in analytical applications.

• Chemically identical to diethanolamine, allowing direct comparative studies.

• Stable, non-radioactive, and easy to handle in standard laboratory conditions.

• Enhances the accuracy and reproducibility of isotope-based quantitation.

HANDLING AND SAFETY

• Handling: Avoid contact with eyes and skin; handle in a fume hood.

• Storage: Keep container tightly closed and stored at 2–8 °C.

• Safety: May cause mild irritation; wear protective gloves, goggles, and lab coat.

• Disposal: Dispose of in accordance with local chemical waste regulations.

SUMMARY
Bis(2-hydroxyethyl)-d8-amine (CAS 103691-51-6) is a high-purity deuterium-labeled derivative of diethanolamine widely used in analytical, biochemical, and spectroscopic studies. Its stability, isotopic accuracy, and identical chemical behavior to the non-deuterated form make it a valuable standard for quantitative mass spectrometry and NMR investigations.