Bisphenol-3,3′,5,5′-d4 | CAS 347841-41-2

OVERVIEW
Bisphenol-3,3′,5,5′-d4 | CAS 347841-41-2 is a deuterated analog of bisphenol compounds widely used in analytical chemistry as an internal standard for accurate quantification in mass spectrometry studies. This highly specialized compound is particularly valuable for laboratories conducting environmental monitoring, pharmacokinetics, toxicology, and endocrine-disruptor research, where precise measurement of bisphenol derivatives is critical.

Deuterated compounds like Bisphenol 3,3′,5,5′-d4 are chemically identical to their non-deuterated counterparts, except that specific hydrogen atoms are replaced with deuterium. This isotopic substitution allows for highly accurate tracing and quantification in complex matrices without altering the chemical behavior of the parent compound.

CHEMICAL INFORMATION

• Chemical Name: Bisphenol 3,3′,5,5′-d4

• CAS Number: 347841-41-2

• Molecular Formula: C15H10D4O2

• Molecular Weight: 190.23 g/mol

• Chemical Structure: Deuterium-substituted bisphenol at positions 3,3′,5,5′

• Purity: Typically ≥98% (subject to batch specification)

The deuteration at the 3,3′,5,5′ positions ensures minimal interference with mass spectrometry analysis, providing a reliable and reproducible signal during isotope dilution studies.

APPLICATIONS
Bisphenol 3,3′,5,5′-d4 is primarily utilized as an internal standard in analytical workflows, especially in high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) or gas chromatography-mass spectrometry (GC-MS). Key applications include:

1. Environmental Analysis:

   • Accurate detection of bisphenol A (BPA) and its analogs in water, soil, and air samples.

   • Monitoring endocrine-disrupting compounds in industrial effluents and consumer products.

2. Toxicology & Pharmacokinetics:

   • Quantitative studies on bisphenol exposure in biological matrices such as blood, urine, and tissues.

   • Supports dose-response analysis, metabolism studies, and biomonitoring research.

3. Endocrine Disruptor Research:

   • Essential for investigating bisphenol-related hormonal activity.

   • Used in in vitro and in vivo studies for tracing bisphenol uptake and metabolism.

4. Analytical Method Development:

   • Facilitates development and validation of sensitive, accurate, and reproducible LC-MS/MS and GC-MS methods.

   • Reduces matrix effects and enhances quantification precision in complex biological and environmental samples.

ADVANTAGES OF USING Bisphenol 3,3′,5,5′-d4 | CAS 347841-41-2

• High Isotopic Purity: Ensures reliable internal standard performance with minimal isotopic cross-talk.

• Chemical Stability: Maintains integrity under typical storage and analytical conditions, ensuring long shelf life.

• Accurate Quantification: Deuterium labeling allows precise measurement of target bisphenol compounds, enhancing reproducibility and reliability of results.

• Versatile Compatibility: Suitable for use with a wide range of chromatographic and mass spectrometry techniques.

STORAGE AND HANDLING
Bisphenol 3,3′,5,5′-d4 should be stored in a cool, dry environment, away from direct sunlight and incompatible materials. Standard laboratory safety procedures should be followed, including the use of personal protective equipment (PPE) such as gloves and eye protection when handling the compound. Proper containment and disposal are essential to minimize environmental contamination and ensure safety in the laboratory.

QUALITY ASSURANCE
At ResolveMass Laboratories Inc., Bisphenol 3,3′,5,5′-d4 is manufactured and supplied under strict quality control measures. Each batch is tested for isotopic purity, chemical integrity, and analytical performance to ensure consistent and reliable results for your research needs. Certificates of analysis (CoA) are provided with every shipment for transparency and traceability.

CONCLUSION
Bisphenol 3,3′,5,5′-d4 (CAS 347841-41-2) is an essential tool for precise quantification of bisphenol compounds in environmental, biological, and toxicological studies. Its high isotopic purity, chemical stability, and compatibility with advanced analytical techniques make it indispensable for laboratories seeking reliable internal standards for mass spectrometry. Whether for research on endocrine disruptors, environmental monitoring, or method development, Bisphenol 3,3′,5,5′-d4 ensures accurate, reproducible, and robust analytical results.

ResolveMass Laboratories Inc. provides this high-quality deuterated bisphenol with guaranteed purity and comprehensive documentation, supporting scientists in achieving the highest standards of research and analytical precision.

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