Carbaryl-d7 (naphthyl-d7) | CAS 362049-56-7

OVERVIEW
Carbaryl-d₇ (naphthyl-d₇) is a deuterium-labelled analogue of carbaryl, a broad-spectrum carbamate insecticide widely used in agricultural and environmental studies. In this isotopically labelled compound, seven hydrogen atoms on the naphthyl ring of carbaryl are replaced with deuterium atoms. This substitution provides a +7 Da mass shift relative to the native molecule, while maintaining identical physicochemical and biological properties.

As a stable isotope-labelled internal standard, Carbaryl-d₇ (naphthyl-d₇) is indispensable for analytical quantification and research involving carbaryl residues and related carbamates. Its high isotopic enrichment ensures excellent traceability and precision in analytical applications, particularly in gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–tandem mass spectrometry (LC-MS/MS).

Carbaryl-d₇ is essential for environmental monitoring, toxicology, and metabolism studies. It supports accurate calibration, method validation, and quality control in pesticide residue analysis. Produced under stringent quality assurance conditions, this compound guarantees high isotopic purity, stability, and reproducibility suitable for regulatory and research laboratories.

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CHEMICAL INFORMATION

•  Name: Carbaryl-d₇; 1-Naphthyl methylcarbamate-d₇; Naphthyl-d₇ carbaryl; Deuterated carbaryl

• Molecular Formula: C₁₂H₄D₇NO₂

• Molecular Weight: 208.27 g/mol

• Isotopic Enrichment: ≥ 98 atom % D

• CAS Number: 362049-56-7

• Structural Formula: C₁₀H₆O₂NCH₃ (with seven deuterium atoms on the naphthyl ring)

• Stability: Stable under normal storage and handling conditions; sensitive to strong acids and bases

Chemically, carbaryl is a methylcarbamate ester of 1-naphthol. The deuterated form (naphthyl-d₇) preserves its carbamate linkage and aromatic structure, ensuring complete equivalence in chromatographic retention and ionization behavior during analytical procedures.

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APPLICATIONS Of Carbaryl-d7 (naphthyl-d7) | CAS 362049-56-7
Carbaryl-d₇ (naphthyl-d₇) is an essential isotopically labelled reference compound widely applied across analytical, environmental, toxicological, and regulatory science disciplines.

1. Analytical Internal Standard for Pesticide Residue Analysis:
   The compound serves as a high-precision internal standard in GC-MS and LC-MS/MS methods for quantifying carbaryl residues in agricultural products, water, soil, and biological matrices. Its stable deuterium labelling ensures identical extraction and chromatographic characteristics to carbaryl while allowing clear mass discrimination for quantitation.

2. Environmental Monitoring and Regulatory Testing:
   Carbaryl is one of the most studied carbamate insecticides due to its widespread agricultural use and environmental persistence. Carbaryl-d₇ is used as a calibration and quality control standard in environmental residue testing programs assessing carbamate contamination and degradation pathways.

3. Toxicological and Metabolism Studies:
   In toxicology, Carbaryl-d₇ supports metabolic profiling, bioaccumulation assessments, and biotransformation studies. Deuterium labelling allows accurate tracing of metabolic products and facilitates kinetic isotope effect investigations in biological systems.

4. Isotope Dilution Mass Spectrometry (IDMS):
   Owing to its precise isotopic composition, Carbaryl-d₇ is ideal for isotope dilution quantification methods. IDMS is the most accurate approach for trace-level determination of pesticide residues, offering unparalleled reproducibility and analytical certainty.

5. Method Validation and Quality Control:
   Laboratories employ Carbaryl-d₇ to establish and verify analytical method parameters such as linearity, precision, accuracy, and recovery. Its consistent behavior across sample types ensures method robustness in complex matrices.

6. Research in Environmental Fate and Degradation:
   Carbaryl-d₇ enables detailed investigation of carbaryl’s degradation mechanisms, including hydrolysis, photolysis, and microbial transformation. It helps researchers distinguish between parent and breakdown products under environmental conditions.

7. Pharmacokinetic and Exposure Studies:
   In biological exposure assessments, Carbaryl-d₇ acts as a labelled tracer for studying uptake, metabolism, and excretion patterns in model organisms and humans, providing insights into risk and safety profiles.

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ADVANTAGES

• High Isotopic Purity: Manufactured with ≥ 98 atom % D for precise analytical differentiation and minimal isotopic interference.

• Exact Structural Equivalence: Identical chemical and physical behavior to native carbaryl ensures accurate quantitation.

• Distinct Mass Shift (M+7): Provides unambiguous identification and mass resolution in MS-based methods.

• Enhanced Analytical Precision: Minimizes measurement uncertainty caused by instrument or matrix variability.

• Excellent Chemical Stability: Deuterium substitution enhances molecular robustness during storage and analysis.

• Broad Applicability: Suitable for environmental, agricultural, biological, and industrial analytical programs.

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HANDLING
As with all carbamate derivatives, Carbaryl-d₇ should be handled with care, adhering to appropriate laboratory safety standards. Although less acutely toxic than many other insecticides, carbaryl analogues can exhibit cholinesterase inhibition at high exposure levels.

• Operate within a fume hood or controlled ventilation system.

• Wear protective gloves, lab coat, and safety goggles.

• Avoid direct contact with skin, inhalation of dust, or ingestion.

• Prevent contamination of reagents and instruments.

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QUALITY & DOCUMENTATION
ResolveMass Laboratories Inc. ensures that every batch of Carbaryl-d₇ (naphthyl-d₇) meets or exceeds international standards for isotopic and chemical purity. Each lot undergoes rigorous analytical characterization and quality verification before distribution.

Documentation provided includes:

• Certificate of Analysis (COA): Confirms isotopic enrichment, chemical purity, and analytical validation results.

• Safety Data Sheet (SDS): Details hazard classifications and recommended handling practices.

• Batch Traceability: Ensures complete documentation from synthesis to release for compliance and reproducibility.

ResolveMass Laboratories Inc. maintains a commitment to providing the highest quality stable isotope-labelled reference materials, designed to support precision, traceability, and confidence in analytical science.

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SUMMARY
Carbaryl-d₇ (naphthyl-d₇) is a premium-grade, deuterium-labelled carbamate compound optimized for analytical, environmental, and toxicological research. Its isotopic stability, chemical fidelity, and reproducibility make it indispensable for laboratories conducting pesticide residue quantification and environmental impact assessments.

With superior isotopic enrichment, high chemical purity, and dependable analytical performance, Carbaryl-d₇ (naphthyl-d₇) from ResolveMass Laboratories Inc. represents a benchmark standard for modern isotope-based analytical science — ensuring precision, reliability, and consistency in every determination.

Learn more,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends