Chlorobenzene-d5 | CAS 3114-55-4

Chlorobenzene-d5 (CAS 3114-55-4) is a highly enriched deuterated analogue of chlorobenzene in which five hydrogen atoms on the aromatic ring are replaced with deuterium (^2H). This isotopically labeled compound is widely used in analytical chemistry, pharmaceutical research, environmental testing, and isotope-labeling studies. Due to its well-defined isotopic composition and excellent chemical stability, Chlorobenzene-d5 serves as an important reference material for mass spectrometry, nuclear magnetic resonance (NMR) spectroscopy, method development, and instrument calibration.

ResolveMass Laboratories Inc. supplies high-quality Chlorobenzene-d5 manufactured to meet the demanding requirements of research laboratories, pharmaceutical companies, academic institutions, and analytical testing facilities. Every batch is produced with strict quality control to ensure high isotopic enrichment, exceptional chemical purity, and reliable analytical performance.

Product Overview

Chlorobenzene-d5 possesses nearly identical chemical properties to conventional chlorobenzene while exhibiting a predictable mass shift due to deuterium substitution. This characteristic makes it an ideal internal standard for quantitative analytical methods where accurate identification and precise quantification are essential.

The compound is commonly employed during analytical method validation, quality control testing, impurity profiling, environmental monitoring, forensic investigations, and metabolomics research. Because it behaves similarly to its unlabeled counterpart throughout extraction, chromatography, and ionization, it helps compensate for sample preparation losses and instrumental variability, ultimately improving analytical accuracy.

Chemical Properties

• Molecular Formula: C₆D₅Cl
• Molecular Weight: 117.59 g/mol
• Appearance: Clear, colorless liquid
• Boiling Point: ~132°C
• Melting Point: ~−45°C
• Density: ~1.14 g/cm³ (20°C)

Applications:

Mass Spectrometry

Chlorobenzene-d5 is extensively used as an internal standard in gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) analyses. Its isotopic labeling enables analysts to distinguish the internal standard from native chlorobenzene while maintaining nearly identical chromatographic behavior. This improves quantitative accuracy by correcting for extraction efficiency, sample preparation losses, and instrument response variations.

Nuclear Magnetic Resonance (NMR) Research

The deuterated structure makes Chlorobenzene-d5 valuable for NMR spectroscopy applications, including instrument calibration, reference studies, and investigations involving isotope effects. Researchers use deuterated compounds to simplify spectral interpretation and improve experimental accuracy.

Pharmaceutical Research

Pharmaceutical laboratories employ Chlorobenzene-d5 during drug development, analytical method validation, impurity studies, stability testing, and quality control. Isotopically labeled compounds are especially useful when developing robust quantitative methods that comply with regulatory expectations.

Environmental Analysis

Environmental testing laboratories utilize Chlorobenzene-d5 as an internal standard for monitoring chlorinated aromatic compounds in soil, water, air, and industrial waste samples. Its consistent analytical behavior supports accurate quantification of environmental contaminants across complex sample matrices.

Forensic Science

Forensic laboratories use Chlorobenzene-d5 during the analysis of volatile organic compounds and related chemical investigations. The isotopic label assists in reliable compound identification while minimizing analytical uncertainty.

Academic and Industrial Research

Researchers across universities and industrial laboratories employ Chlorobenzene-d5 in isotope-labeling experiments, analytical chemistry studies, reaction mechanism investigations, and method optimization projects. Its predictable physicochemical properties make it a valuable tool in numerous scientific disciplines.

Advantages of Using Chlorobenzene-d5

Selecting an isotopically labeled internal standard offers significant advantages over external calibration alone. Chlorobenzene-d5 compensates for variations introduced during sample preparation, extraction, chromatographic separation, and detector response. This leads to:

• Improved quantitative accuracy
• Enhanced analytical precision
• Better reproducibility between analytical runs
• Reduced matrix effects
• Increased confidence in analytical results
• More reliable method validation
• Greater consistency across multiple laboratories

Because the compound closely mimics the behavior of native chlorobenzene, it provides highly reliable correction factors without interfering with analyte detection.

Quality Assurance

ResolveMass Laboratories Inc. is committed to supplying premium isotope-labeled reference materials that meet the needs of modern analytical laboratories. Chlorobenzene-d5 is produced using carefully controlled manufacturing processes and undergoes comprehensive quality testing to verify identity, isotopic enrichment, purity, and consistency.

Each production batch is evaluated according to established quality standards to ensure dependable performance in demanding analytical workflows. Our commitment to quality enables researchers and laboratories to obtain reproducible and reliable analytical data.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. specializes in the development and supply of high-quality isotope-labeled standards, analytical reference materials, pharmaceutical impurities, and research chemicals. Our products are trusted by scientists working in pharmaceutical development, biotechnology, environmental analysis, clinical research, forensic science, and academic institutions worldwide.

When you choose ResolveMass Laboratories Inc., you benefit from:

• Premium-quality isotope-labeled compounds
• Stringent quality assurance and testing
• Consistent batch-to-batch performance
• Reliable technical support
• Products designed for advanced analytical applications
• Commitment to scientific excellence and customer satisfaction

Order Chlorobenzene-d5 (CAS 3114-55-4)

ResolveMass Laboratories Inc. offers Chlorobenzene-d5 (CAS 3114-55-4) for research and analytical applications requiring high isotopic purity and dependable performance. Whether your laboratory is conducting pharmaceutical method development, environmental monitoring, forensic investigations, or advanced analytical research, our Chlorobenzene-d5 provides the quality and consistency necessary for accurate and reproducible results.

Contact ResolveMass Laboratories Inc. today to learn more about product specifications, availability, custom quantities, and technical support for your analytical and research requirements.

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