Decanoic-d19-acid | CAS 88170-22-3

OVERVIEW  of  Decanoic-d19-acid | CAS 88170-22-3

Decanoic-d₁₉-acid, also known as capric-d₁₉ acid, is a fully deuterated analog of decanoic acid, a ten-carbon saturated fatty acid naturally present in coconut oil, palm kernel oil, and milk fat. This compound has the chemical formula C₁₀D₁₉O₂ and a molecular weight of approximately 177.36 g/mol. In this isotopically labeled derivative, all 19 hydrogen atoms are replaced by deuterium, providing a distinct mass spectral profile ideal for use in mass spectrometry (MS), lipidomics, metabolomics, and biochemical research.

Decanoic-d₁₉-acid is valued as a stable isotope-labeled internal standard for accurate quantification and tracing of fatty acids in complex biological samples. Its isotopic labeling allows precise differentiation from native decanoic acid, making it essential for studies involving lipid metabolism, energy regulation, and medium-chain triglyceride (MCT) oxidation.

By maintaining the same structural and physicochemical properties as the unlabeled parent compound, this deuterated fatty acid behaves identically in chromatographic and biochemical systems, ensuring analytical reliability and metabolic relevance.

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CHEMICAL INFORMATION

• Name: Decanoic-d₁₉-acid

• CAS Number: 88170-22-3

• Molecular Formula: C₁₀D₁₉O₂

• Molecular Weight: 191.38 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Chemical Class: Deuterated medium-chain saturated fatty acid

• Solubility: Insoluble in water; soluble in organic solvents such as chloroform, ethanol, ether, and hexane

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APPLICATIONS  of  Decanoic-d19-acid | CAS 88170-22-3
Decanoic-d₁₉-acid serves as an indispensable reference and tracer compound in multiple scientific and industrial research disciplines. Its deuterium enrichment provides the precision required for quantitative and qualitative analyses of fatty acids, lipid intermediates, and metabolic products.

1. Mass Spectrometry Internal Standard:
Used as a stable isotope-labeled internal standard in GC-MS and LC-MS/MS assays for decanoic acid quantification in biological matrices. The deuterium substitution generates a distinct mass shift, enabling accurate isotopic differentiation and quantitation in complex lipid mixtures.

2. Lipidomics and Metabolomics:
Essential in lipidomics workflows for profiling medium-chain fatty acids. It supports the accurate quantification of lipid components in plasma, liver, muscle, or food matrices. By providing a defined isotopic reference, Decanoic-d₁₉-acid helps normalize sample variability and enhances data reliability in metabolomic analysis.

3. Metabolic Tracing and Flux Studies:
Frequently used in isotope tracer experiments to investigate fatty acid oxidation, β-oxidation pathways, and energy metabolism. Deuterated decanoic acid allows researchers to follow metabolic fluxes with high precision and sensitivity, providing insights into mitochondrial fatty acid utilization.

4. Nutritional and Biomedical Research:
Plays a significant role in understanding medium-chain triglyceride metabolism and their impact on neurological function, ketogenic diets, and energy balance. Deuterium-labeled fatty acids like Decanoic-d₁₉-acid enable in vivo metabolic tracing without altering native biochemical behavior.

5. Pharmaceutical and Toxicological Studies:
Used to evaluate drug–lipid interactions, absorption, and metabolism in preclinical pharmacokinetic studies. It also assists in characterizing the metabolic stability of fatty acid conjugates used in drug delivery systems and formulations.

6. Analytical Method Validation:
Employed as a calibration and performance standard for chromatographic and spectrometric method validation. The stable isotopic signature ensures high reproducibility, even in trace-level fatty acid quantification.

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ADVANTAGES  of  Decanoic-d19-acid | CAS 88170-22-3

• Exceptional Isotopic Enrichment: Provides clean and distinct isotopic signals for mass spectrometry-based quantification.

• High Chemical Stability: Retains structural integrity under various analytical and storage conditions.

• Accurate Quantification: Ideal for isotope dilution methods, improving accuracy and reproducibility of fatty acid analysis.

• Biochemical Relevance: Mimics native decanoic acid in biological systems, ensuring physiologically meaningful results.

• Versatile Analytical Utility: Compatible with GC, LC, GC-MS, LC-MS/MS, and NMR analytical platforms.

• Enhanced Method Reliability: Reduces analytical variability and improves the precision of metabolomic and lipidomic workflows.

• Stable During Derivatization: Maintains isotopic and structural integrity through methylation, silylation, or esterification processes commonly used in analytical chemistry.

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SUMMARY
Decanoic-d₁₉-acid (CAS 88170-22-3) is a fully deuterated, high-purity analog of natural decanoic acid designed for advanced analytical and biochemical applications. Its deuterium enrichment provides a precise isotopic marker for quantitative fatty acid analysis, lipid profiling, and metabolic tracing.

At ResolveMass Laboratories Inc., this compound is produced under rigorous quality assurance to ensure exceptional isotopic and chemical purity. It supports cutting-edge research in lipid metabolism, energy utilization, and pharmaceutical development.

By incorporating Decanoic-d₁₉-acid into analytical and metabolic studies, researchers gain a powerful tool for elucidating lipid dynamics, validating analytical methods, and enhancing reproducibility in complex biological investigations. This compound continues to serve as a cornerstone reference material in isotope-labeled lipidomics, enabling more accurate and meaningful interpretations of metabolic and biochemical data.

 

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