Decanoyl-L-Carnitine-d3 HCl (N-methyl-d3) | CAS 2483831-87-2

OVERVIEW  of  Decanoyl-L-Carnitine-d3 HCl (N-methyl-d3) | CAS 2483831-87-2
Decanoyl-L-Carnitine-d₃ HCl (N-methyl-d₃) is a stable isotopically labeled form of decanoyl-L-carnitine, a medium-chain acylcarnitine involved in fatty acid transport across the mitochondrial membrane. In this compound, the three hydrogen atoms on the N-methyl group of the L-carnitine moiety are substituted with deuterium, resulting in a molecular weight increase of +3 Da. This labeling does not alter its chemical or biochemical behavior but allows for precise detection and quantification in analytical studies.

It is primarily used as an internal standard for LC-MS/MS-based metabolomics and lipidomics, enabling accurate quantitation of native decanoyl-L-carnitine in biological matrices such as plasma, serum, and tissues.

CHEMICAL INFORMATION

• Name: Decanoyl-L-Carnitine-d₃ hydrochloride

• Molecular Formula: C₁₇H₃₁D₃NO₄·HCl

• Molecular Weight: 354.93 g/mol

• CAS Number: 2483831-87-2

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated acylcarnitine; stable isotope-labeled metabolite

• Stability: Stable under inert and dry conditions; hygroscopic

APPLICATIONS  of  Decanoyl-L-Carnitine-d3 HCl (N-methyl-d3) | CAS 2483831-87-2

• Metabolomics and Lipidomics:
  Acts as a stable isotope-labeled internal standard for quantification of decanoyl-L-carnitine in targeted LC-MS/MS assays, ensuring high analytical precision and accuracy.

• Clinical Biochemistry:
  Used for diagnostic quantification of medium-chain acylcarnitines in biological fluids, aiding in the identification of fatty acid oxidation disorders (FAODs) such as MCAD deficiency.

• Mass Spectrometry Method Development:
  Serves as a calibration compound for method validation, retention time alignment, and ionization efficiency correction in mass spectrometry workflows.

• Energy Metabolism Studies:
  Supports biochemical research into mitochondrial fatty acid β-oxidation, energy transport, and lipid metabolism by serving as a labeled tracer molecule.

• Quantitative Bioanalysis:
  Compensates for matrix effects and instrument variability during the quantitative determination of acylcarnitine concentrations in complex biological samples.

ADVANTAGES  of  Decanoyl-L-Carnitine-d3 HCl (N-methyl-d3) | CAS 2483831-87-2

• High isotopic enrichment (≥ 98 atom % D) ensures reliable signal distinction in MS-based quantification.

• Isotopically labeled analog maintains identical chromatographic and ionization behavior to the native compound.

• Non-radioactive and chemically stable, suitable for routine analytical workflows.

• Enhances data reproducibility and quality control in quantitative metabolomics.

HANDLING, STORAGE & SAFETY

• Hazards: Non-toxic in analytical use; follow standard laboratory precautions.

• Precautions: Avoid inhalation or ingestion; wear gloves and protective eyewear.

• Storage: Keep at –20 °C under inert gas or desiccated conditions to prevent degradation.

• Disposal: Dispose according to local regulations for non-hazardous organic compounds.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Form: Crystalline or lyophilized solid

• Analytical Verification: Confirmed by LC-MS/MS and NMR spectroscopy

• Documentation: Supplied with a Certificate of Analysis (CoA) detailing isotopic enrichment and chemical integrity

SUMMARY
Decanoyl-L-Carnitine-d₃ HCl (N-methyl-d₃) | CAS 2483831-87-2 is a deuterium-labeled internal standard used in metabolomic, lipidomic, and biochemical research. It provides exceptional analytical accuracy for the quantitative determination of acylcarnitines in complex biological matrices. Its stability, isotopic purity, and compatibility with LC-MS/MS systems make it indispensable for studies on mitochondrial function, fatty acid metabolism, and energy balance in clinical and research environments.

Learn more about,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 

How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 

How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 

Deuterium-Labelled Compounds — Synthesis, Applications & Ordering