Deuterated 2-(Methoxy)ethyl acrylate-d10

OVERVIEW

Deuterated 2-(Methoxy)ethyl acrylate-d10 is a fully deuterium-labeled acrylate monomer engineered for advanced analytical, polymerization, and mechanistic research applications. Its structure incorporates ten deuterium atoms distributed across the methoxy and ethyl moieties, providing an isotopically enriched analogue ideally suited for NMR spectroscopy, mass spectrometry, kinetic tracing, and isotopic dilution studies. Because acrylate monomers serve as versatile building blocks across coatings, biomedical polymers, adhesives, and reactive intermediate research, a deuterated variant offers unique advantages for scientists who require high chemical fidelity with enhanced spectroscopic clarity.

ResolveMass Laboratories Inc. supplies high-purity, research-grade isotopically labeled monomers designed to support modern polymer science, pharmaceutical research, biomaterials development, and mechanistic organic chemistry. Deuterated 2-(Methoxy)ethyl acrylate-d10 exemplifies this approach—combining chemical precision, batch-to-batch reproducibility, and analytical consistency.

CHEMICAL INFORMATION

• Chemical Name: Deuterated 2-(Methoxy)ethyl acrylate-d10

• Synonyms:

  • 2-Methoxyethyl acrylate-d10

  • MEA-d10

  • Acrylate-d10 monomer

• Molecular Formula: C6D10O3

• Isotopic Labeling: 10 deuterium atoms

• Chemical Class: Acrylate ester; deuterated monomer

• Typical Purity: ≥98% (as supplied for research use)

• Physical Form: Clear liquid (typical for acrylate esters)

The introduction of ten deuterium atoms does not significantly alter the core reactivity of the acrylate group, allowing researchers to investigate polymerization behavior, degradation, or conversion pathways with minimal perturbation while obtaining enhanced structural resolution in analytical methods.

PHYSICOCHEMICAL PROPERTIES

Deuterated 2-(Methoxy)ethyl acrylate-d10 retains the functional profile of its protonated counterpart with nearly identical reactivity but markedly improved spectral characteristics.

• Functional Group: Acrylate ester (enabling radical and photopolymerization)

• Spectroscopic Behavior:

  • Strongly reduced or absent proton NMR signals in labeled regions

  • Simplified spectra for mechanistic studies

  • Enhanced mass spectral signal due to predictable mass shifts

• Stability: Sensitive to light, heat, and radical initiators (common to acrylates)

• Solubility: Miscible with common organic solvents (THF, acetone, dichloromethane, acetonitrile)

These attributes make the labeled monomer exceptionally useful for tracking polymer chain growth, evaluating conversion pathways, and distinguishing labeled vs. unlabeled segments in copolymers.

APPLICATIONS  of  Deuterated 2-(Methoxy)ethyl acrylate-d10

1. NMR Spectroscopy and Structural Elucidation
The deuterium substitution eliminates proton resonance from key molecular positions, making this monomer an excellent internal reference or tracer in ^1H, ^2H, and multinuclear NMR studies. Researchers can focus on polymer backbone signals without interference from side-chain protons, improving resolution and peak assignment.

2. Mass Spectrometry and Isotopic Tracing
With a mass shift corresponding to ten deuterium atoms, the compound is a highly effective internal standard. It supports:

• Quantitative LC-MS workflows

• Mechanistic kinetic isotope studies

• Isotopic dilution methods

• Fragmentation pathway mapping

These characteristics enhance analytical precision, especially in complex polymer or biomaterial matrices.

3. Polymer Research and Mechanistic Studies
Because the acrylate group remains chemically intact, Deuterated 2-(Methoxy)ethyl acrylate-d10 participates seamlessly in radical, UV-initiated, and controlled polymerization systems such as ATRP, RAFT, and free-radical chain growth. Deuterium labeling allows researchers to:

• Trace monomer incorporation

• Distinguish polymer microstructures

• Study degradation pathways

• Monitor mass changes during crosslinking or curing

Such capabilities are important for coating science, hydrogel design, nanomaterials, and biomedical polymer development.

4. Interaction Studies in Biomaterials
Deuterated monomers are often used to track polymer-protein, polymer-cell, or polymer-drug interactions. The isotopic label allows precise quantitation in complex biological systems, enabling biomaterials researchers to evaluate binding, uptake, and release behaviors.

5. Reaction Mechanism and Kinetic Isotope Effect (KIE) Research
The presence of deuterium can help clarify rate-determining steps in radical propagation, ester cleavage, or side-chain reactions. KIE studies support mechanistic organic chemistry and catalysis research where proton transfer steps are relevant.

ANALYTICAL ADVANTAGES

• Reduced spectral overlap in NMR

• Strong deuterium signals for tracking

• Predictable mass shifts in MS

• More accurate quantification in mixed monomer systems

• Enhanced ability to distinguish product vs. precursor pathways

These benefits significantly support polymer chemists, analytical scientists, pharmaceutical R&D teams, and research laboratories performing precision structural or mechanistic studies.

WHY CHOOSE RESOLVEMASS LABORATORIES INC.

ResolveMass Laboratories Inc. supplies high-quality isotopically labeled compounds backed by strict analytical validation, ensuring consistency, purity, and reproducibility for demanding scientific applications. Our deuterated monomers, including Deuterated 2-(Methoxy)ethyl acrylate-d10, are manufactured following rigorous quality benchmarks to support polymer science, pharmaceutical formulation, and advanced analytical research.

Learn more through,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

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