Deuterated Acrylamide-d3 | CAS 122775-19-3

OVERVIEW

Deuterated Acrylamide-d3 | CAS 122775-19-3 is a stable isotope-labeled analog of acrylamide in which three hydrogen atoms on the vinyl group are substituted with deuterium (²H). This isotopic incorporation makes Acrylamide-d3 an essential internal standard and tracer molecule for applications in quantitative mass spectrometry, metabolic tracking, polymer science, and environmental toxicology studies. Because of its structural similarity to non-deuterated acrylamide and its minimal impact on chemical reactivity, Acrylamide-d3 is widely used to ensure analytical accuracy, improve signal differentiation, and enhance method robustness in complex biological and chemical matrices.

ResolveMass Laboratories Inc. supplies high-purity research-grade Acrylamide-d3 designed to meet the demanding needs of analytical chemistry, biopharmaceutical research, and polymer analysis workflows. Its isotopic stability, chemical consistency, and reproducible performance make it an indispensable material for laboratories performing isotope dilution studies or validating acrylamide quantification methods in foods, biological fluids, and environmental samples.

CHEMICAL INFORMATION

Chemical Name: Acrylamide-d3
Synonyms: Acryloylamide-d3, 2-Propenamide-d3, Acrylamide-2,3,3-d3
CAS Number: 122775-19-3
Molecular Formula: C₃D₃NO
Molecular Weight:  74.06 g/mol
Isotopic Labeling: Three deuterium atoms substituted on vinyl positions
Purity: High-purity deuterated compound suitable for LC–MS/GC–MS analytical workflows

The incorporation of deuterium subtly increases molecular mass while maintaining the chemical functionality of the acrylamide moiety. This ensures that Acrylamide-d3 behaves nearly identically to its non-deuterated counterpart within reaction pathways, chromatographic systems, and polymerization reactions—making it exceptionally valuable for internal standardization and kinetic studies.

KEY FEATURES & SCIENTIFIC BENEFITS

1. Ideal Internal Standard for LC–MS and GC–MS

Acrylamide-d3 delivers tightly controlled isotopic shifts that allow MS instruments to distinguish labeled molecules from native acrylamide. This makes it highly effective for quantifying trace acrylamide levels in food products (such as baked goods, processed foods, and coffee), biological samples, and environmental matrices where ultra-low detection limits are required.

2. High Isotopic Purity Ensures Analytical Accuracy

Because isotope dilution analysis relies on accurate mass differences, the isotopic purity of Acrylamide-d3 is critical. ResolveMass Laboratories Inc. ensures minimal hydrogen back-exchange and consistently high deuterium incorporation, supporting reliable quantitation in regulatory-focused analytical workflows.

3. Supports Mechanistic and Kinetic Investigations

Its structural fidelity to native acrylamide allows Acrylamide-d3 to be used in:

• Polymerization rate studies

• Reaction mechanism evaluation

• Isotope-effect investigations

• Metabolic pathway tracing

Researchers in polymer chemistry and toxicology rely on Acrylamide-d3 as a reference material to understand reaction rates or to track acrylamide behavior within biological systems.

4. Suitable for Food Safety and Environmental Monitoring

Acrylamide is a well-studied contaminant of concern in cooked carbohydrate-rich foods. Because regulatory agencies require rigorous testing protocols, Acrylamide-d3 is integrated into validated methods such as:

• Isotope dilution LC–MS/MS for acrylamide quantification

• Method development and validation workflows

• Routine monitoring studies in food safety laboratories

Environmental chemists also use Acrylamide-d3 to evaluate sources, degradation pathways, and exposure risks associated with acrylamide contamination in soil or water systems.

APPLICATIONS of  Deuterated Acrylamide-d3 | CAS 122775-19-3

Analytical Chemistry

• Internal standard for quantifying acrylamide via LC–MS/MS and GC–MS

• Calibration of analytical instruments for trace-level detection

• Validation of acrylamide extraction and sample-preparation workflows

Food Chemistry & Toxicology

• Acrylamide monitoring in processed foods

• Compliance testing for global food-safety regulations

• Toxicokinetic and exposure studies

Environmental Analysis

• Detection of acrylamide in soil, groundwater, and industrial effluents

• Assessment of environmental degradation pathways

• Pollution source identification using isotope tracing

Polymer Science

• Kinetic analysis of acrylamide polymerization

• Mechanistic studies involving isotopic substitution

• Evaluation of reaction intermediates in acrylamide-based polymers

WHY CHOOSE RESOLVEMASS LABORATORIES INC.

ResolveMass Laboratories Inc. specializes in supplying high-purity, research-grade isotopically labeled chemicals, ensuring reliable performance in advanced analytical applications. Our rigorous quality control, batch consistency, and scientific support ensure that researchers, analytical laboratories, and industrial clients receive dependable materials for their workflows.

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