Deuterated Aniline-d7 | CAS 14545-23-4

Deuterated Aniline-d7 | CAS 14545-23-4 is a stable isotope-labeled analog of aniline in which all seven hydrogen atoms are replaced with deuterium atoms, resulting in a characteristic M+7 mass shift. This isotopic substitution preserves the compound’s chemical behavior while providing a distinct mass difference that enables precise identification and quantification using modern analytical techniques. Aniline-d7 is widely employed as an internal standard in LC-MS/MS, GC-MS, isotope dilution mass spectrometry (IDMS), and various pharmaceutical, environmental, forensic, and chemical research applications. It is typically supplied with an isotopic purity of approximately 98 atom % D and a molecular weight of 100.17 g/mol.

At ResolveMass Laboratories Inc., we understand the importance of reliable isotope-labeled reference materials for quantitative analytical workflows. High-quality deuterated standards such as Aniline-d7 help laboratories achieve greater accuracy, reproducibility, and regulatory confidence during method development, validation, and routine sample analysis.

Product Information

Product Name: Deuterated Aniline-d7

CAS Number: 14545-23-4

Molecular Formula: C₆D₇N

Molecular Weight: 100.17 g/mol

Mass Shift: M+7

Appearance: Clear to pale yellow liquid (may vary depending on storage conditions)

Isotopic Purity: Typically ≥98 atom % D

Applications of Deuterated Aniline-d7

Deuterated Aniline-d7 serves as an essential analytical reference material across numerous scientific disciplines. Because it exhibits nearly identical chemical properties to native aniline while producing a distinguishable mass spectrum, it is an ideal internal standard for quantitative mass spectrometry.

Common applications include:

• LC-MS/MS quantitative analysis
• Gas chromatography-mass spectrometry (GC-MS)
• Isotope dilution mass spectrometry (IDMS)
• Pharmaceutical impurity profiling
• Environmental contaminant monitoring
• Occupational exposure assessment
• Forensic toxicology
• Chemical synthesis research
• Method development and analytical validation
• Instrument calibration and quality control

Its use significantly improves analytical precision by compensating for sample preparation losses, extraction variability, chromatographic fluctuations, and ionization efficiency differences.

Benefits of Using Aniline-d7 as an Internal Standard

Stable isotope-labeled compounds have become indispensable tools in modern analytical laboratories. Aniline-d7 offers several advantages over conventional external calibration methods.

Improved Quantitative Accuracy

Since Aniline-d7 closely mimics the physicochemical behavior of native aniline throughout extraction, chromatography, and ionization, it minimizes analytical bias and improves quantification.

Enhanced Precision

The compound compensates for day-to-day instrument variability, resulting in excellent repeatability and reproducibility across analytical batches.

Better Matrix Compensation

Complex biological, pharmaceutical, food, and environmental samples often exhibit matrix effects that suppress or enhance ionization. Aniline-d7 corrects these variations, leading to more reliable results.

Regulatory Compliance

Stable isotope-labeled internal standards are widely recommended during analytical method validation under international regulatory expectations for pharmaceutical and bioanalytical testing.

Robust Method Validation

Analytical laboratories use Aniline-d7 during validation studies involving accuracy, precision, recovery, linearity, robustness, and stability assessments.

Pharmaceutical Research Applications

Pharmaceutical laboratories routinely employ Aniline-d7 during the development and validation of analytical methods for compounds containing aromatic amine functionalities. The isotope-labeled standard supports:

• Drug substance analysis
• Drug product testing
• Process impurity monitoring
• Residual analysis
• Quality control testing
• Stability studies
• Manufacturing process development

Because the labeled compound co-elutes with native aniline while remaining distinguishable by mass spectrometry, analysts obtain highly accurate quantitative measurements even at trace concentration levels.

Environmental and Industrial Monitoring

Aniline is an important industrial chemical used in the manufacture of dyes, polymers, rubber additives, agrochemicals, and specialty chemicals. Environmental laboratories frequently monitor aniline contamination in water, soil, wastewater, and industrial emissions.

Aniline-d7 provides an ideal internal standard for these analyses by improving recovery calculations and minimizing analytical uncertainty during environmental monitoring programs.

Research and Method Development

Academic institutions, CROs, contract testing laboratories, and industrial R&D facilities rely on Aniline-d7 during analytical method optimization. Researchers use the compound to evaluate:

• Extraction efficiency
• Sample recovery
• Instrument performance
• Matrix effects
• Detection limits
• Quantitative robustness

Its predictable chromatographic behavior simplifies method optimization across multiple analytical platforms.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. supplies premium-quality stable isotope-labeled reference materials designed to meet the demanding requirements of pharmaceutical, biotechnology, environmental, and research laboratories. Our products are selected to support accurate quantitative analysis, analytical method validation, and regulatory compliance.

We are committed to delivering:

• High-purity isotope-labeled standards
• Reliable analytical performance
• Consistent product quality
• Technical expertise in mass spectrometry applications
• Responsive customer support
• Products suitable for research, analytical, and laboratory use

Whether supporting routine quality control or advanced analytical research, ResolveMass Laboratories Inc. provides dependable isotope-labeled compounds that help laboratories generate precise, reproducible, and defensible analytical data.

Storage and Handling

For optimal stability, Deuterated Aniline-d7 should be stored in tightly sealed containers under the storage conditions specified in the accompanying Certificate of Analysis or Safety Data Sheet. Proper handling minimizes contamination, moisture exposure, and isotopic degradation, ensuring long-term analytical performance. Users should follow standard laboratory safety practices and applicable regulatory guidelines when handling this research chemical.

Order Deuterated Aniline-d7

ResolveMass Laboratories Inc. offers high-quality Deuterated Aniline-d7 (CAS 14545-23-4) for research and analytical applications. Our isotope-labeled standards are suitable for LC-MS/MS, GC-MS, isotope dilution mass spectrometry, analytical method development, pharmaceutical research, environmental testing, and quality control laboratories. Contact our team today to learn more about product availability, technical specifications, and custom isotope-labeled reference standards tailored to your analytical requirements.

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