Deuterated Isobutylene-d8

OVERVIEW
Deuterated Isobutylene-d8 is a fully deuterated analog of isobutylene in which all eight hydrogen atoms are replaced with deuterium (²H). This isotopically enriched olefin plays a crucial role in analytical chemistry, polymer science, kinetic studies, and mechanistic investigations. Owing to its distinctive spectroscopic signature and high isotopic purity, isobutylene-d8 enables researchers to track molecular transformations, quantify reaction pathways, and develop advanced polymer materials with rigorously controlled behavior.

ResolveMass Laboratories Inc. supplies high-purity, research-grade Deuterated Isobutylene-d8 designed specifically for demanding applications in catalysis, reaction mechanism elucidation, NMR spectroscopy, and polymer modification. Its stability, accurate isotopic enrichment, and clean impurity profile make it an essential tool for pharmaceutical, chemical, and materials R&D.

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CHEMICAL INFORMATION
• Chemical Name: Isobutylene-d8 (2-methylpropene-d8)
• Molecular Formula: C₄D₈
• Molecular Weight: 64.16 g/mol
• Isotopic Enrichment: Typically ≥98% D
• Structure: Fully deuterated C=C substituted with CD₃ and CD groups

Deuterated Isobutylene-d8 retains the chemical reactivity of its protonated counterpart but shows altered vibrational frequencies and kinetic isotope effects, making it valuable for mechanism-specific research.

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KEY FEATURES
• High deuterium enrichment suitable for quantitative isotopic tracing
• Sharp and easily distinguishable NMR signatures
• Ideal for polymerization kinetic studies involving cationic, radical, and metallocene catalysts
• Excellent stability under recommended storage conditions
• Gas-phase olefin enabling rapid gas-phase or solution-phase reactions
• Low residual proton content, ensuring reliable isotopic purity in analytical methods

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APPLICATIONS

1. Mechanistic and Kinetic Studies
Deuterated Isobutylene-d8 is widely used to investigate reaction mechanisms in organic synthesis and catalysis. The presence of deuterium alters reaction rates through primary and secondary kinetic isotope effects, allowing chemists to pinpoint rate-determining steps, evaluate rearrangements, and differentiate between competing reaction pathways. It is especially valuable in studying electrophilic addition, cation migration, olefin polymerization, and proton-driven reactions.

2. Advanced Polymer Science
Isobutylene-d8 serves as a unique monomer for producing deuterium-labeled polymers such as deuterated polyisobutylene (PIB-d). These materials enable:
• Chain-growth tracking during polymerization
• Neutron scattering experiments requiring contrast variation
• Diffusion and permeability studies in polymer blends
• Investigation of polymer degradation pathways in industrial materials

The ability to incorporate deuterium into polymer backbones makes it indispensable in elastomer research, ionomer characterization, and block copolymer morphology studies.

3. Spectroscopy and Analytical Chemistry
Deuterated Isobutylene-d8 is widely used as a reference and internal standard for:
• NMR spectroscopy (¹H, ²H, and ¹³C)—It provides clear spectral differentiation due to absence of proton resonances and shifted carbon signals.
• Mass spectrometry (MS)—The mass shift from C₄H₈ to C₄D₈ enables direct quantification, fragmentation analysis, and calibration.
• Infrared (IR) spectroscopy—C–D stretching bands offer useful contrast for tracking bond formation and cleavage.

Its spectroscopic clarity significantly enhances precision in structural elucidation, impurity analysis, and reaction monitoring.

4. Pharmaceutical & Chemical R&D
Isobutylene-d8 supports the development of deuterated drug analogs, metabolic pathway studies, and isotope-effect-driven API optimization. It allows researchers to evaluate stability, degradation routes, and binding interactions in a controlled and quantifiable manner.

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RESEARCH & DEVELOPMENT BENEFITS
• Enables high-fidelity tracking of molecular transformations
• Facilitates precise mechanistic interpretation in catalytic systems
• Supports polymer design tailored for energy, medical, and industrial applications
• Improves accuracy in metabolite identification, impurity profiling, and reaction monitoring
• Provides a scalable isotopic tool for academic and industrial research laboratories

Learn more through,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 

How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 

How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 

Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 

Custom Synthesis of Deuterated Chemicals