Deuterated Maleic Anhydride-d2 | CAS 33225-51-3

Deuterated Maleic anhydride-d2 | CAS 33225-51-3 is a stable isotope-labeled analogue of maleic anhydride in which two hydrogen atoms are replaced with deuterium (^2H or D). This isotopically enriched compound is extensively used in analytical chemistry, pharmaceutical research, metabolite identification, reaction mechanism studies, and isotope dilution mass spectrometry (IDMS). The incorporation of deuterium provides a predictable mass shift while preserving the chemical behavior of the native molecule, making it an ideal internal standard for quantitative LC-MS and GC-MS analyses. The compound typically exhibits a molecular formula of C₄D₂O₃, a molecular weight of approximately 100.07 g/mol, and a characteristic M+2 mass shift resulting from the incorporation of two deuterium atoms. Commercial research-grade material is commonly supplied with 98 atom % deuterium enrichment.

At ResolveMass Laboratories Inc., we supply premium-quality deuterated reference standards manufactured to meet the demanding requirements of pharmaceutical companies, CROs, academic laboratories, and analytical testing facilities worldwide. Every isotope-labeled compound is produced with stringent quality controls to ensure exceptional isotopic purity, chemical purity, batch consistency, and analytical reliability.

Product Specifications

The replacement of hydrogen atoms with deuterium does not significantly alter the compound’s chemical reactivity, allowing Deuterated Maleic anhydride-d2 to closely mimic the behavior of unlabeled maleic anhydride during chromatographic separation while remaining distinguishable by mass spectrometry.

Applications of Deuterated Maleic Anhydride-d2

LC-MS and GC-MS Internal Standard

One of the primary applications of Deuterated Maleic anhydride-d2 is as an internal standard during quantitative mass spectrometric analysis. Stable isotope-labeled standards compensate for variability introduced during sample preparation, extraction, ionization efficiency, and instrumental fluctuations, significantly improving quantitative accuracy.

Researchers utilize the compound for:

• Quantitative LC-MS assays
• GC-MS analytical methods
• Method validation
• Trace-level quantification
• Analytical quality control
• Isotope dilution mass spectrometry (IDMS)

Pharmaceutical Research

Pharmaceutical laboratories frequently employ deuterated compounds throughout drug discovery and development. Deuterated Maleic anhydride-d2 supports:

• Analytical method development
• Drug impurity analysis
• Stability studies
• Forced degradation investigations
• Process chemistry monitoring
• Pharmaceutical quality control

The isotope label enables scientists to differentiate the internal standard from endogenous or process-derived compounds while maintaining nearly identical chromatographic behavior.

Chemical Synthesis Research

Maleic anhydride is an important intermediate in synthetic organic chemistry. Its deuterated analogue assists researchers studying:

• Reaction mechanisms
• Isotope exchange reactions
• Kinetic isotope effects
• Catalyst performance
• Polymer chemistry
• Organic reaction optimization

Because the isotope substitution minimally affects chemical properties, researchers can investigate reaction pathways with greater confidence.

Metabolomics and Analytical Chemistry

Stable isotope-labeled standards have become indispensable tools in metabolomics and bioanalytical laboratories. Deuterated Maleic anhydride-d2 enables:

• Accurate metabolite quantification
• Matrix effect correction
• Instrument calibration
• Biomarker research
• Environmental monitoring
• Chemical exposure studies

These applications benefit from improved reproducibility and reduced analytical bias.

Benefits of Using Deuterated Standards

Compared with external calibration alone, isotope-labeled internal standards provide several important analytical advantages:

• Superior quantitative accuracy
• Improved method precision
• Compensation for extraction losses
• Correction of ion suppression or enhancement
• Better reproducibility across laboratories
• Enhanced regulatory compliance
• Reliable long-term analytical performance
• Improved trace-level detection

These advantages explain why deuterated reference standards are widely recommended in pharmaceutical and bioanalytical laboratories performing validated LC-MS/MS and GC-MS analyses.

Quality Assurance at ResolveMass Laboratories Inc.

ResolveMass Laboratories Inc. is committed to providing high-quality isotope-labeled reference materials that support modern analytical workflows. Our stable isotope products undergo rigorous quality evaluation to ensure:

• High isotopic enrichment
• Excellent chemical purity
• Batch-to-batch consistency
• Comprehensive analytical characterization
• Reliable long-term stability
• Secure packaging and worldwide distribution

Each production lot is manufactured to support demanding analytical applications where precision and reproducibility are critical.

Storage and Handling

To maintain product integrity, Deuterated Maleic anhydride-d2 should be stored in a tightly sealed container under cool, dry conditions away from moisture. Because maleic anhydride readily reacts with water to form maleic acid, minimizing exposure to humidity is essential. Appropriate laboratory safety procedures, including the use of gloves, eye protection, and adequate ventilation, should always be followed when handling this material.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. serves pharmaceutical, biotechnology, academic, and contract research laboratories with premium analytical reference standards and isotope-labeled compounds. Our expertise in analytical chemistry enables us to supply products that meet the highest expectations for research and regulatory applications.

Our customers benefit from:

• High-purity stable isotope standards
• Reliable global supply
• Expert analytical support
• Competitive pricing
• Fast worldwide shipping
• Consistent product quality
• Responsive customer service
• Custom isotope synthesis capabilities

Whether supporting pharmaceutical method validation, metabolomics research, chemical synthesis, or advanced mass spectrometry, ResolveMass Laboratories Inc. delivers dependable isotope-labeled standards that enhance analytical confidence.

Order Deuterated Maleic Anhydride-d2

If your laboratory requires a dependable isotope-labeled reference standard for quantitative mass spectrometry, analytical method development, or pharmaceutical research, Deuterated Maleic anhydride-d2 (CAS 33225-51-3) from ResolveMass Laboratories Inc. offers the quality and consistency required for demanding scientific applications. Our commitment to precision manufacturing, rigorous quality assurance, and customer-focused technical support makes us a trusted partner for analytical laboratories worldwide.

Contact ResolveMass Laboratories Inc. today to request pricing, product specifications, or additional information about our comprehensive portfolio of deuterated reference standards and stable isotope-labeled compounds.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals