Deuterated Methacrylic acid-d5 | CAS 55935-46-1

OVERVIEW

Deuterated Methacrylic acid-d5 | CAS 55935-46-1 is a stable-isotope-labeled analog of methacrylic acid in which five hydrogen atoms are replaced by deuterium. This structural modification preserves the core chemical reactivity and polymerization performance of the native monomer while enabling precise analytical tracking, metabolic quantification, reaction pathway elucidation, and advanced spectroscopic studies. Owing to its unique isotopic signature, MAA-d5 is widely used in polymer science, NMR spectroscopy, environmental fate studies, and mechanistic investigations of polymerization kinetics.

At ResolveMass Laboratories Inc., our Deuterated Methacrylic Acid-d5 is produced to high isotopic and chemical purity standards, supporting demanding research applications in materials science, biomedical engineering, and analytical chemistry.

---

CHEMICAL INFORMATION

Chemical Name: Methacrylic Acid-d5
CAS Number: 55935-46-1
Molecular Formula: C4D5O2
Molecular Weight: 91.2 g/mol 
Structure: Deuterated analog of methacrylic acid with CD₂═C(CD₃)–COOH
Isotope Enrichment: Typically ≥98% D (varies by specification)
Functional Groups: Carboxylic acid, vinyl group

The incorporation of deuterium stabilizes certain reaction pathways, alters vibrational frequencies, and provides a distinct mass-spectrometric signature without removing the characteristic polymerizable double bond. This makes MAA-d5 especially valuable for kinetic isotope effect (KIE) studies and polymer chain distribution investigations.

---

KEY FEATURES

• High isotopic purity ensures accurate quantitation in LC–MS, GC–MS, and NMR-based assays.

• Chemically identical behavior to non-deuterated methacrylic acid, enabling direct comparative experiments.

• Excellent compatibility with radical polymerization, copolymerization, grafting, and surface modification processes.

• Useful tracer molecule for environmental or degradation pathway studies.

• Stable under recommended storage conditions, maintaining isotopic integrity over long periods.

---

APPLICATIONS of Deuterated Methacrylic acid-d5 | CAS 55935-46-1

1. Polymerization & Materials Research

Deuterated Methacrylic Acid-d5 is widely used for studying polymer growth mechanisms, chain termination events, and radical propagation steps. Differences in reaction rates caused by the isotope effect allow researchers to map detailed mechanistic pathways. Additionally, its distinct isotopic mass makes it ideal for:

• Tracking individual monomer incorporation events

• Quantifying end-group conversion

• Studying degradation behavior of methacrylate-based polymers

• Understanding copolymer composition drift in time-resolved studies

2. NMR Spectroscopy

MAA-d5 is commonly used as an NMR label due to its reduced proton background and unique deuterium signal. Applications include:

• Investigating polymer microstructures

• Monitoring monomer conversion in real time

• Conducting reaction kinetics analyses

• Examining molecular mobility and micro-environment interactions

Its deuterium labeling enables high clarity in ²H NMR, while ¹³C spectra benefit from reduced proton–carbon coupling.

3. Mass Spectrometry & Analytical Tracers

MAA-d5 provides a precisely identifiable mass shift in MS, making it excellent for:

• Quantitative isotope dilution assays

• Metabolic and degradation tracking

• Monitoring polymer residual monomers

• Internal standardization for complex sample matrices

Because the deuterium atoms are stable and non-exchangeable under typical conditions, the molecule retains its isotopic signature throughout analysis.

4. Environmental Fate & Degradation Studies

Researchers use labeled methacrylic acid analogs to:

• Trace biodegradation pathways

• Evaluate environmental mobility of methacrylate-based compounds

• Understand breakdown mechanisms in soil or aquatic environments

• Validate degradation kinetics of polymeric materials

The unique isotopic fingerprint ensures sensitive detection even in multi-component systems.

5. Biomedical & Life Science Research

MAA-d5 is utilized in specialized biomedical studies, including:

• Tracking methacrylate-based drug delivery polymers

• Studying in vivo degradation profiles of polymeric implants

• Quantifying interactions at biological interfaces

• Metabolic profiling of methacrylate-derived intermediates

Its non-radioactive nature makes it safe and convenient for sensitive research applications.

---

WHY CHOOSE RESOLVEMASS LABORATORIES?

ResolveMass Laboratories Inc. provides isotopically enriched monomers manufactured with precision and validated for consistency, purity, and reproducibility. Our focus on research-grade quality ensures that Deuterated Methacrylic Acid-d5 meets the stringent demands of academic, industrial, and regulatory environments. Every batch is backed by analytical documentation, technical expertise, and responsive scientific support to help researchers generate reliable, publication-ready data.

 

 

Learn more through,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 

How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 

How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 

Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 

Custom Synthesis of Deuterated Chemicals