Deuterated Methacryloyl chloride-d5

OVERVIEW

Deuterated Methacryloyl chloride-d5 is a highly specialized isotopically labeled reagent used across advanced polymer chemistry, materials science, and analytical research. As the deuterated analogue of methacryloyl chloride, this compound replaces five hydrogen atoms with deuterium (D), creating a unique isotopic signature that is invaluable for mechanistic studies, kinetic investigations, NMR quantification, and the synthesis of deuterium-enriched polymers.

Because of its activated acyl chloride functionality, Methacryloyl Chloride-d5 readily reacts with nucleophiles such as alcohols, amines, and thiols, enabling efficient incorporation of the methacrylate moiety into a wide range of molecular architectures. Researchers frequently use this reagent to prepare deuterated methacrylates, specialized monomers, crosslinkers, and labeled copolymers designed for structure–property correlation studies and analytical method development.

At ResolveMass Laboratories Inc., Deuterated Methacryloyl Chloride-d5 is manufactured and quality-tested using strict analytical controls to ensure isotopic purity, chemical identity, and stability for high-precision research applications.

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CHEMICAL INFORMATION

Chemical Name: Methacryloyl chloride-d5
Synonyms: Methacrylic acid chloride-d5, Methacryloyl-d5 chloride
Isotopic Labeling: 5 deuterium atoms
Functional Group: Activated acyl chloride (methacryloyl)
General Reactivity: Highly reactive toward nucleophiles; moisture-sensitive; releases HCl upon hydrolysis.

Deuterated Methacryloyl Chloride-d5 maintains all the electrophilic characteristics of its non-deuterated counterpart, allowing researchers to perform acylation and esterification reactions with similar kinetics while benefiting from deuterium tracing and spectral differentiation. The high D-labeling efficiency ensures clear NMR separation between proton-bearing and deuterium-bearing fragments, improving analytical accuracy in both structural and kinetic investigations.

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FEATURES & BENEFITS

• Isotopically Enriched for Precise Analytical Tracking
Deuterium incorporation allows researchers to distinguish labeled segments during NMR, GC–MS, LC–MS, and IR analysis. This is critical for polymer degradation studies, reaction monitoring, and quantitative assessments of functionalization efficiency.

• High Chemical Reactivity for Efficient Derivatization
The acyl chloride group reacts cleanly with alcohols, thiols, and amines to form stable methacrylate esters or amides, enabling rapid synthesis of custom monomers or polymer precursors.

• Ideal for Mechanistic and Kinetic Studies
The deuterium atoms provide a kinetic isotope effect (KIE) useful for elucidating reaction pathways, studying radical polymerization behavior, and evaluating structural rearrangements.

• Essential for Advanced Material Design
Labeled methacrylates derived from this reagent are used in polymer dynamics research, self-assembly studies, biomedical material development, and degradation-pathway analysis.

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APPLICATIONS of Deuterated Methacryloyl chloride-d5 

• Synthesis of Deuterated Methacrylate Monomers
Researchers commonly convert Deuterated Methacryloyl Chloride-d5 into customized methacrylate esters for polymerization studies. The resulting monomers are ideal for tracking incorporation ratios, segmental mobility, and degradation routes in copolymer systems.

• Polymer Science, Copolymerization & Crosslinking
Deuterated methacrylates are used in free-radical, RAFT, ATRP, and controlled polymerization systems to investigate molecular weight distribution, chain transfer events, and polymerization kinetics with enhanced clarity due to isotopic markers.

• Reaction Mechanism & Kinetic Isotope Effect Studies
Methacryloyl chloride-d5 is highly valuable for probing pathways in acylation reactions and for quantifying kinetic isotope effects. This helps researchers understand surface reactions, polymer initiation mechanisms, and catalytic processes.

• NMR-Based Characterization
The compound’s deuterium content significantly reduces peak overlap in ¹H NMR spectra, enabling more accurate structural assignments. It also improves sensitivity in ²H NMR experiments, supporting diffusion, tracking, and segmental mobility analysis.

• LC–MS & GC–MS Internal Standards
Stable isotopic enrichment makes Methacryloyl Chloride-d5 suitable as a reference standard for analytical method development, quantification of methacrylate derivatives, and validation of impurity profiling workflows.

• Biomedical and Pharmaceutical Materials Research
Deuterated methacrylates are essential for studying the degradation behavior of polymeric drug carriers, hydrogels, and tissue-engineering scaffolds. The deuterium label provides a clear way to monitor polymer breakdown and drug-release-triggering events.

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WHY CHOOSE RESOLVEMASS LABORATORIES INC.

ResolveMass Laboratories Inc. supports advanced materials research by providing highly characterized, isotopically enriched reagents with dependable purity and stability. Each batch of Deuterated Methacryloyl Chloride-d5 undergoes rigorous QA/QC using NMR (¹H, ²H), LC–MS, Karl Fischer moisture analysis, and GC purity verification. Our quality systems ensure that researchers receive a consistent, reliable reagent suitable for high-precision scientific experimentation and analytical method development.

Learn more through,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 

How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 

How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 

Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 

Custom Synthesis of Deuterated Chemicals