Deuterated Methyl acrylate-d3 | CAS 35777-12-9

OVERVIEW

Deuterated Methyl acrylate-d3 | CAS 35777-12-9 is a highly valuable isotopically enriched monomer used widely in analytical chemistry, mechanistic organic chemistry, polymer science, and kinetic isotope studies. Structurally analogous to methyl acrylate, this compound incorporates three deuterium atoms in place of hydrogens within the methyl ester group, creating a stable, non-exchangeable isotopic label. Its strong reactivity, chemical simplicity, and clean spectroscopic behavior make Methyl Acrylate-d₃ an essential building block in advanced research workflows, especially where deuterium tracing, reaction pathway elucidation, or mass spectrometric quantification is required.

At ResolveMass Laboratories Inc., we supply high-purity, research-grade Deuterated Methyl Acrylate-d₃ tailored for demanding R&D applications in pharmaceuticals, materials science, isotope-labelled polymer development, and quantitative analytical method development. Our product is manufactured under rigorous quality systems designed to support reliable spectroscopic performance and reproducible reaction outcomes.

CHEMICAL INFORMATION

• Chemical Name: Deuterated Methyl Acrylate-d₃
• CAS Number: 35777-12-9
• Molecular Formula: C₄H₃D₃O₂
• Molecular Weight: ~100.12 g/mol (isotopically enriched)
• Isotopic Enrichment: Typically ≥98 atom % D (product-specific values available on request)
• Synonyms:
– Methyl Acrylate-d₃
– MA-d₃
– d₃-Methyl Acrylate
– CD₃-OCO-CH=CH₂

This deuterated acrylate is chemically identical to methyl acrylate in reactivity, enabling seamless substitution in polymerization and derivatization reactions while providing isotopic contrast for analytical studies.

KEY FEATURES & BENEFITS

• High Deuterium Incorporation: Ensures strong NMR signal separation, predictable mass shifts in MS, and high confidence in kinetic isotope effect (KIE) studies.
• Excellent Reagent Stability: Non-exchangeable deuterium atoms offer consistent isotopic labeling even under typical reaction and storage conditions.
• Versatile Reactivity: The acrylate double bond supports radical polymerization, Michael addition, and cross-linking chemistry.
• Ideal for Quantitative Analysis: Provides sharp, distinguishable peaks in GC-MS, LC-MS, and NMR experiments for internal standards or tracer applications.
• Compatible with Complex Systems: Suitable for polymer matrices, biological samples, metabolite profiling workflows, and materials R&D.

APPLICATIONS  of  Deuterated Methyl acrylate-d3 | CAS 35777-12-9

1. NMR Spectroscopy (“Silent” Regions for Structural Studies)
The three deuterium atoms in Methyl Acrylate-d₃ significantly reduce ^1H NMR signals around the methyl region, enabling clean spectral interpretation. Researchers employ it for:
• Peak deconvolution
• Reaction intermediate tracking
• Structural confirmation in esters and acrylate derivatives

2. Mass Spectrometry (Internal Standards & Isotope Dilution Quantification)
The consistent mass shift imparted by the three deuterium atoms makes this compound an excellent internal standard for isotope-dilution MS. It supports:
• Quantitative GC-MS and LC-MS workflows
• Metabolite synthesis and calibration curves
• Trace-level detection of acrylates in complex matrices

3. Polymer Science & Mechanistic Polymerization Studies
Deuterated Methyl Acrylate-d₃ is widely used to probe polymerization kinetics and chain-growth mechanisms. Its applications include:
• Copolymer sequence analysis via NMR and MS
• Mechanistic elucidation of radical polymerization
• Diffusion and swelling studies in polymer networks
• Deuterium-labelled block copolymer preparation

4. Kinetic Isotope Effect (KIE) Studies
The presence of CD₃ instead of CH₃ alters bond vibrational energy, enabling researchers to study:
• Rate-determining steps in catalytic reactions
• Mechanistic pathways in ester hydrolysis
• Radical propagation and termination processes

5. Synthesis of Deuterated Fine Chemicals & Reference Standards
Methyl Acrylate-d₃ serves as a precursor for:
• Deuterated esters
• Labelled polymers (PMMA-dₓ, copolymers, hydrogels)
• Analytical reference materials
• Pharmaceutical impurity standards

TECHNICAL ADVANTAGES FOR PHARMACEUTICAL & MATERIALS R&D

In modern research environments, isotopic precision is essential. Deuterated Methyl Acrylate-d₃ enables advanced studies that require:
• Highly resolved NMR datasets to evaluate microstructural differences in polymers
• Reliable internal standards for quantifying acrylates in stability studies
• Tools to differentiate synthetic pathways through isotopic tracing
• Enhanced understanding of polymer degradation and diffusion mechanisms

For pharmaceutical development, it supports impurity tracking, metabolite identification, and formulation analytics. For polymer and materials science, it enables labelled network mapping, reaction monitoring, and advanced material characterization.

WHY CHOOSE RESOLVEMASS LABORATORIES INC.

ResolveMass provides deuterated reagents with exceptional reliability, purity, and technical documentation. Our supply chain emphasizes traceability, batch consistency, and analytical verification—including isotope purity confirmation and spectral data upon request. Researchers trust our products for complex R&D tasks where data integrity is non-negotiable.

Our technical specialists also support custom isotopic reagent sourcing, project advisory, and method development assistance for academic, industrial, and pharmaceutical innovation programs.

Learn more through,

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