OVERVIEW

Deuterated Methyl methacrylate-d8 | CAS 35233-69-3 is a high-purity, isotopically enriched monomer widely used in polymer research, analytical chemistry, tracer studies, and materials science. Structurally derived from methyl methacrylate with eight deuterium atoms replacing the corresponding hydrogen atoms, this compound offers enhanced mass differentiation, stronger NMR signal resolution, and improved tracking in complex systems. Its chemical robustness and compatibility with conventional polymerization mechanisms make it a valuable resource for researchers investigating polymer dynamics, degradation, reaction tracing, and mechanistic modeling.

ResolveMass Laboratories Inc. provides high-purity MMA-d8 optimized for reproducible analytical performance, ensuring low residual moisture, excellent isotopic enrichment, and consistent chemical integrity suitable for advanced R&D and regulated laboratory environments.

CHEMICAL INFORMATION

• Chemical Name: Deuterated Methyl Methacrylate-d8

• CAS Number: 35233-69-3

• Molecular Formula: C5D8O2

• Molecular Weight: 108.17 g/mol (approx., depends on enrichment)

• Isotopic Enrichment: High deuteration level (commonly >98 atom% D)

• Chemical Class: Deuterated methacrylate ester; vinyl monomer

• Functional Groups: Vinyl group – suitable for radical polymerization; ester group – chemically stable yet responsive in reaction mechanisms

The deuteration of the methyl and methylene groups reduces proton-based signal interference, allowing precise structural identification and kinetic evaluation of methacrylate-based systems. Its mass shift (due to substituted deuterium) also supports high-resolution MS tracking.

KEY FEATURES & BENEFITS

High Isotopic Purity

MMA-d8 is enriched with deuterium to enable clear analytical separation from non-deuterated analogs. This high isotopic purity ensures consistent performance in NMR and mass spectrometry-based investigations.

Enhanced NMR Performance

The removal of proton signals significantly improves:

• Baseline clarity

• Peak assignment accuracy

• Quantitative deuterium NMR measurements

• Structural elucidation of methacrylate-based polymers

Ideal for Tracer and Mechanistic Studies

The isotopic labeling offers a powerful tool to:

• Track polymer growth

• Study radical propagation mechanisms

• Evaluate migration pathways

• Investigate monomer reactivity and stability

Compatible with Standard Polymerization Techniques

MMA-d8 participates in:

• Free-radical polymerization

• Atom Transfer Radical Polymerization (ATRP)

• RAFT polymerization

• Photopolymerization

This compatibility ensures seamless integration into current material synthesis workflows.

APPLICATIONS  of  Deuterated Methyl methacrylate-d8 | CAS 35233-69-3

1. Polymer Science & Polymerization Mechanism Studies

Deuterated Methyl Methacrylate-d8 is extensively utilized to investigate methacrylate polymer chains, co-polymer formation, radical propagation, termination steps, and degradation behaviors. It acts as a selective NMR probe to differentiate polymer segments and identify structural heterogeneity.

2. NMR Spectroscopy & Structural Analysis

The absence of proton signals and the presence of deuterium enables:

• Accurate ^2H NMR quantification

• Subtle structural identification in polymethacrylate matrices

• Monitoring of polymer conversion and crosslinking

• Analysis of reaction intermediates

Researchers frequently use MMA-d8 to map polymer microstructure and sequence distribution.

3. Mass Spectrometry Tracing & Labeling Studies

The mass shift imparted by deuterium enhances:

• Fragmentation pattern clarity

• Identification of degradation products

• Tracking monomer migration in biomedical or food-contact materials

• Mechanistic elucidation in polymer aging studies

4. Material Science & Surface Engineering

MMA-d8 supports studies involving:

• Polymer film formation

• Self-assembled coatings

• Nanocomposites

• Smart or responsive materials

• Optical and dielectric material development

Deuteration can also alter vibrational modes, making MMA-d8 suitable for IR spectroscopy and Raman scattering characterization.

5. Environmental Fate & Toxicological Studies

Researchers apply MMA-d8 as an isotopically labeled reference for:

• Metabolic and biotransformation pathways

• Environmental degradation tracing

• Partition coefficient analysis

• Quantification in environmental samples using LC–MS/MS

QUALITY & COMPLIANCE

ResolveMass Laboratories Inc. supplies MMA-d8 that aligns with rigorous research-grade standards. Each batch undergoes analytical verification including:

• NMR isotopic purity assessment

• GC or HPLC purity checks

• Residual solvent analysis (DCM, acetone, ethyl acetate, etc.)

• Moisture content evaluation

These quality measures ensure reliability for high-precision applications in analytical chemistry, pharmaceuticals, and materials R&D.

STORAGE & HANDLING NOTES

Deuterated Methyl Methacrylate-d8 should be stored in a cool, dry environment away from light and sources of heat to maintain isotopic integrity. As with all methacrylate monomers, inhibitors may be present to prevent premature polymerization. Users should avoid exposure to reactive species and ensure the container remains tightly sealed.

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