Deuterated N-Isopropyl acrylamide-d10 | CAS 1219803-32-3

OVERVIEW
Deuterated N-Isopropyl acrylamide-d10 | CAS 1219803-32-3 is a high-purity isotopically labeled monomer widely used in advanced polymer research, analytical studies, and drug delivery system development. The deuterium-labeled variant provides enhanced stability and unique spectroscopic properties, making it indispensable in applications requiring precise molecular tracking and NMR analysis. Its fully deuterated isopropyl group ensures minimal proton interference in experiments, improving analytical accuracy for researchers in both academic and industrial settings.

As a specialized chemical offered by ResolveMass Laboratories Inc., NIPAM-d10 meets stringent quality requirements suitable for polymer synthesis, NMR spectroscopy, and kinetic studies. Researchers can rely on its consistent isotopic composition for reproducible results, critical for mechanistic studies and high-precision applications.

CHEMICAL INFORMATION

• Chemical Name: N-Isopropyl acrylamide-d10

• CAS Number: 1219803-32-3

• Molecular Formula: C6H1D10NO

• Molecular Weight: 123.15 g/mol (fully deuterated)

• Purity: Typically ≥ 98%

• Appearance: White crystalline powder

KEY FEATURES AND ADVANTAGES

1. High Isotopic Purity: NIPAM-d10 is fully deuterated at the isopropyl group, enabling precise isotopic labeling for advanced NMR studies and mass spectrometry analysis.

2. Analytical Reliability: Ideal for quantitative NMR, LC–MS, and GC–MS studies, providing accurate results with minimal background interference.

3. Polymer Research Applications: Serves as a monomer in the synthesis of temperature-responsive and smart polymers, such as poly(N-isopropyl acrylamide) hydrogels, for controlled drug delivery and biomaterials research.

4. Kinetic and Mechanistic Studies: Deuterium labeling allows researchers to trace molecular behavior and reaction pathways, providing critical insights into polymerization mechanisms and molecular interactions.

5. Versatility: Suitable for diverse applications, including isotopic exchange studies, metabolic tracing, and the development of deuterated materials for advanced analytical research.

APPLICATIONS  of  Deuterated N-Isopropyl acrylamide-d10 | CAS 1219803-32-3
1. NMR and Spectroscopy Studies:
Deuterated N-Isopropyl acrylamide-d10 is a preferred internal standard or tracer in proton NMR and deuterium NMR experiments. Its deuterium content reduces proton interference, enhancing signal clarity and facilitating detailed molecular structure elucidation.

2. Polymer Synthesis:
NIPAM-d10 is commonly employed in the preparation of temperature-sensitive polymers and copolymers, especially poly(N-isopropyl acrylamide) hydrogels. These polymers are widely studied for drug delivery, tissue engineering, and stimuli-responsive materials due to their reversible thermal phase transitions. Deuterium labeling enables monitoring of polymerization kinetics and molecular interactions without perturbing the polymer’s thermal properties.

3. Mass Spectrometry and Isotopic Tracing:
The deuterium atoms in NIPAM-d10 provide a distinct mass shift in mass spectrometry, making it an excellent choice for quantitative LC–MS and GC–MS applications. Researchers can use it to study degradation pathways, polymer metabolism, and isotopic incorporation in complex systems.

4. Drug Delivery and Biomaterials Research:
Due to its biocompatible and temperature-responsive nature, NIPAM-d10 is utilized in the design of hydrogels and nanocarriers for controlled drug release. Its deuterium-labeled form allows researchers to track molecular distribution and stability in vivo or in vitro studies.

STORAGE AND HANDLING
Deuterated N-Isopropyl acrylamide-d10 should be stored in a tightly sealed container under inert atmosphere or at low temperatures to maintain stability. Avoid exposure to moisture, strong oxidizing agents, and prolonged heat. Proper personal protective equipment should be used when handling to prevent inhalation or skin contact.

QUALITY AND REGULATORY COMPLIANCE
ResolveMass Laboratories Inc. provides NIPAM-d10 with rigorous quality control standards to ensure high purity, accurate isotopic labeling, and reproducible performance. Analytical data, including NMR spectra and HPLC purity, are provided with each batch, supporting research-grade and industrial applications.

CONCLUSION
Deuterated N-Isopropyl acrylamide-d10 (CAS 1219803-32-3) is a premium isotopically labeled monomer that plays a critical role in polymer research, analytical chemistry, and drug delivery studies. Its high deuterium content, excellent purity, and reliable performance make it a trusted choice for scientists aiming to achieve precise and reproducible results in advanced applications. ResolveMass Laboratories Inc. ensures consistent supply and quality, supporting cutting-edge research and development needs across academia and industry.

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