Deuterated N-Isopropyl-d7 acrylamide | CAS 1219803-32-3

OVERVIEW

Deuterated N-Isopropyl-d7 acrylamide | CAS 1219803-32-3 is a specialized isotopically labeled monomer derived from N-Isopropylacrylamide (NIPAM). In this compound, all seven hydrogen atoms in the isopropyl group are replaced with deuterium, resulting in a stable and highly pure monomer suitable for advanced research applications. The deuteration provides unique physical properties that are particularly valuable in analytical and polymer science studies.

As a solid monomer, N-Isopropyl-d7 acrylamide is primarily used to synthesize deuterated polymers, enabling the investigation of molecular dynamics, polymer behavior, and thermoresponsive properties in a way that is not achievable with the non-deuterated analog. It serves as a crucial tool in research settings that require precision, reproducibility, and isotopic labeling.

CHEMICAL AND PHYSICAL CHARACTERISTICS

• Synonyms: N-Isopropyl-d7 acrylamide; N-(Isopropyl-d7)acrylamide; N-Isopropylacrylamide-d7

• Molecular Formula: C₆H₄D₇NO

• Molecular Weight: 120.20 g/mol

• Isotopic Purity: ≥98–99 atom % deuterium

• Physical Form: Solid monomer, typically provided in small quantities for research use

• Storage Conditions: Refrigerated, tightly sealed, dry environment to maintain stability and purity

The high isotopic purity ensures that the compound is well-suited for studies where the presence of hydrogen could interfere with experimental outcomes. Proper storage under recommended conditions maintains both chemical integrity and deuterium content over extended periods.

RELATION TO NIPAM AND BENEFITS OF DEUTERATION

N-Isopropylacrylamide is widely used for creating poly(N-isopropylacrylamide) (PNIPAM), a thermo-responsive polymer that exhibits a sharp phase transition in aqueous solution. Below its critical solution temperature, PNIPAM remains hydrated and soluble, while above this temperature, it collapses into a hydrophobic state.

By replacing the hydrogen atoms with deuterium, researchers can synthesize deuterated PNIPAM (d-PNIPAM) to study polymer dynamics, phase transitions, and hydration behavior with high precision. Deuteration allows scientists to utilize advanced analytical techniques such as neutron scattering, deuterium NMR, and mass spectrometry to observe molecular behavior, polymer–solvent interactions, and network formation with minimal interference from hydrogen atoms.

Deuterated monomers like N-Isopropyl-d7 acrylamide also facilitate studies on isotope effects, including subtle changes in thermodynamic properties, kinetic behavior, and transition temperatures, providing deeper insight into polymer science and material design.

APPLICATIONS  of  Deuterated N-Isopropyl-d7 acrylamide | CAS 1219803-32-3

Deuterated N-Isopropyl-d7 acrylamide is designed for specialized research applications, including:

• Synthesis of deuterated thermo-responsive polymers and hydrogels for advanced material studies

• Investigation of polymer dynamics, phase behavior, and chain mobility in aqueous and solvent systems

• Analytical labeling for mass spectrometry, NMR spectroscopy, and neutron scattering experiments

• Fundamental studies on isotope effects in polymer chemistry and material science

• Preparation of deuterium-labeled standards or tracers for analytical and experimental workflows

Its precise isotopic labeling and high chemical purity make it ideal for experiments requiring accurate tracking of molecular interactions or phase transitions.

SAFETY AND HANDLING

Deuterated N-Isopropyl-d7 acrylamide is classified as harmful if ingested and may cause eye irritation. Proper laboratory safety procedures should be followed when handling this compound:

• Use appropriate personal protective equipment, including gloves, protective clothing, and eye/face protection

• Handle in a well-ventilated area or fume hood

• In case of ingestion, do not induce vomiting; rinse mouth and seek medical attention

• In case of eye contact, rinse thoroughly with water and seek medical advice

• In case of inhalation, move to fresh air and seek medical attention if breathing is difficult

• Store refrigerated, tightly sealed, and protected from moisture and oxidizing agents

These precautions ensure safe handling and minimize risk while working with the compound in laboratory environments.

QUALITY AND SUPPLIER INFORMATION

N-Isopropyl-d7 acrylamide is supplied with high chemical and isotopic purity, typically greater than 97% chemical purity and 98–99% isotopic enrichment. It is offered in small-scale quantities appropriate for bench-scale research and experimental polymer synthesis. Small vial sizes allow researchers to work efficiently and minimize material waste while conducting highly specialized studies.

This compound is ideal for laboratories seeking a high-quality, research-grade monomer for deuterated polymer synthesis, analytical experiments, or isotope-effect studies. Its availability from ResolveMass Laboratories Inc. ensures reliable supply, consistent purity, and the necessary quality for cutting-edge polymer research.

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