Deuterated N-isopropyl methacrylamide-d5 | CAS 1219803-32-3

OVERVIEW

Deuterated N-isopropyl methacrylamide-d5 | CAS 1219803-32-3 is an isotopically labeled monomer in which five hydrogen atoms of the isopropyl substituent are replaced with deuterium. This deuterium substitution provides a chemically identical but spectroscopically distinct analogue of native N-isopropyl methacrylamide (NIPAM), enabling precise tracking, quantification, and mechanistic study of polymer behavior in advanced materials research, polymer physics, biomedical engineering, and isotope-sensitive analytical methods.

Because NIPAM polymerizes to form poly(N-isopropyl methacrylamide) (PNIPAM) — a well-known thermo-responsive polymer exhibiting a lower critical solution temperature (LCST) around 32 °C in aqueous media — the availability of a deuterated monomer provides researchers with an exceptional tool for probing PNIPAM’s hydration, phase transitions, molecular conformation, and structural dynamics using neutron scattering, NMR spectroscopy, and other isotopic-resolution techniques.

ResolveMass Laboratories Inc. supplies high-purity, research-grade NIPAM-d5, ensuring batch consistency, reliable polymerization performance, and accurate isotopic incorporation for demanding analytical and formulation needs.

CHEMICAL INFORMATION

Chemical Name:
Deuterated N-isopropyl methacrylamide-d5

CAS Number:
1219803-32-3

Molecular Formula:
C₇H₇D₅NO₂

Isotopic Labeling:
Five deuterium atoms replacing hydrogens on the isopropyl group

Functional Class:
Deuterated vinyl monomer; isotopically labeled methacrylamide

Key Features:

• High deuterium enrichment (typically ≥ 98% D)

• Excellent solubility in organic solvents and partial solubility in water

• Retains all polymerization characteristics of native NIPAM

• Ideal for spectroscopic and neutron-based investigations

SCIENTIFIC SIGNIFICANCE

The availability of a deuterated derivative of NIPAM expands the analytical toolkit for studying soft materials and responsive polymer systems. Deuterium labeling enhances signal discrimination, reduces background noise, and improves structural resolution in techniques where hydrogen–deuterium substitution yields substantial analytical benefits.

Many research fields depend heavily on isotopically labeled monomers, particularly when examining polymer–solvent interactions, polymer chain mobility, hydration phenomena, and stimuli-responsive behavior. NIPAM-d5 is among the most valuable monomers for such investigations because PNIPAM is a benchmark material for phase-transition studies.

APPLICATIONS of Deuterated N-isopropyl methacrylamide-d5 | CAS 1219803-32-3

1. Neutron Scattering Studies (SANS, SNS, Neutron Reflectometry)

Hydrogen possesses a high incoherent neutron scattering cross-section, which often limits data quality in neutron-based analysis. Replacing H with D dramatically enhances signal clarity.
NIPAM-d5 enables:

• Detailed mapping of PNIPAM hydration shells

• Precise measurement of polymer coil–globule transitions

• Contrast-variation experiments in polymer blends, hydrogels, and nanostructures

• Structural quantification of PNIPAM in complex matrices

This makes it indispensable for polymer physics, biopolymer interaction studies, and soft-matter research.

2. NMR Spectroscopy and Isotopic Tracking

Deuterium labeling improves spectral resolution by minimizing proton-proton coupling and allowing selective detection methods in:

• ¹H-NMR suppression experiments

• D-NMR tracking of polymer segments

• Quantitative isotope tracing

• Monitoring polymer growth and degradation

Researchers working on controlled radical polymerization (RAFT, ATRP, NMP) frequently incorporate NIPAM-d5 into monomer feeds to quantify chain transfer events and confirm uniform incorporation.

3. Thermo-Responsive Polymer Research

PNIPAM is one of the most studied thermo-responsive polymers. Using the deuterated monomer allows deeper insight into:

• LCST-driven conformational changes

• Water–polymer interaction thermodynamics

• Solvation layer reorganization

• Kinetic modeling of temperature-induced phase transitions

This is particularly relevant in biomedical hydrogel design, smart drug-delivery systems, and environmental sensing materials.

4. Polymer Nanoparticles and Micelle Characterization

NIPAM-d5 is widely used to study nanoscale self-assembly processes, allowing researchers to:

• Track nanoparticle formation pathways

• Distinguish core vs. corona composition in block copolymers

• Evaluate drug encapsulation environments

• Quantify hydration levels in microgel networks

5. Advanced Materials and Interdisciplinary Research

Additional application areas include:

• Bio-inspired soft actuators

• Responsive thin films and coatings

• Adhesion studies under thermal stimuli

• Hybrid organic–inorganic material characterization

Because deuteration does not significantly alter reactivity, mechanical properties, or polymer morphology, results remain fully comparable to non-deuterated PNIPAM, ensuring scientific reliability.

ADVANTAGES FOR RESEARCHERS

Using high-purity NIPAM-d5 sourced from ResolveMass Laboratories provides several key benefits:

• Enhanced Analytical Quality: Isotopic enrichment improves clarity in neutron and NMR experiments.

• Batch-to-Batch Reproducibility: Essential for kinetic studies, high-precision polymer physics research, and quantitative isotope analysis.

• Compatibility With All Polymerization Platforms: RAFT, ATRP, anionic, free-radical, or controlled polymerization approaches.

• Reliable Integration Into Complex Copolymer Systems: Ideal for block copolymers, graft architectures, and functional hydrogels.

• Support for Pharmaceutical and Bioengineering R&D: Particularly valuable for studying drug-loaded PNIPAM nanoparticles and temperature-responsive biomaterials.

RESEARCH & TECHNICAL SUPPORT

ResolveMass Laboratories Inc. provides technical assistance for researchers working with isotopically labeled monomers. Support includes:

• Polymerization guidance

• Copolymer design recommendations

• Material characterization strategies

• Assistance with neutron or NMR-oriented study planning

Our team ensures that each batch of NIPAM-d5 meets the stringent requirements expected in advanced materials science and analytical research.

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