Deuterated Vinyl Acetate-d6 | CAS 189765-98-8

Deuterated Vinyl Acetate-d6 for Analytical Research and Stable Isotope Applications

Deuterated Vinyl Acetate-d6 (CAS 189765-98-8) is a high-purity stable isotope-labelled analogue of vinyl acetate in which all six hydrogen atoms are replaced by deuterium (²H). This isotopically enriched compound retains nearly identical chemical behavior to the native molecule while exhibiting a predictable mass shift, making it an invaluable reference material for analytical chemistry, pharmaceutical research, environmental studies, and isotope tracing experiments. The molecular formula is C₄D₆O₂, with a molecular weight of approximately 92.13 g/mol.

Stable isotope-labelled compounds such as Vinyl Acetate-d6 are widely utilized in modern analytical laboratories because they provide exceptional accuracy in quantitative mass spectrometry. Their nearly identical physicochemical properties to the non-labelled compound ensure that both analyte and internal standard behave similarly during sample preparation, chromatographic separation, and ionization. This minimizes analytical variability and improves reproducibility across complex sample matrices.

At ResolveMass Laboratories Inc., we supply high-quality Deuterated Vinyl Acetate-d6 for research, analytical method development, isotope dilution studies, and pharmaceutical applications. Every batch is produced under stringent quality standards to support reliable and reproducible analytical performance.

Chemical Properties

• Product Name: Deuterated Vinyl Acetate-d6
• CAS Number: 189765-98-8
• Molecular Formula: C₄D₆O₂
• Molecular Weight: 92.13 g/mol
• Appearance: Clear, colorless liquid
• Isotopic Enrichment: Typically ≥98 atom % D
• Boiling Point: ~72–73°C

Applications of Deuterated Vinyl Acetate-d6:

LC-MS/MS Internal Standard

One of the primary applications of Vinyl Acetate-d6 is as an internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS). The deuterium atoms create a measurable mass difference while maintaining nearly identical chromatographic behavior to unlabeled vinyl acetate. This enables accurate correction for extraction efficiency, instrument response variation, and matrix effects.

GC-MS Quantitative Analysis

The compound is extensively employed in gas chromatography-mass spectrometry (GC-MS) for quantitative determination of vinyl acetate in environmental, industrial, pharmaceutical, and chemical samples. Stable isotope-labelled internal standards significantly improve analytical precision and method robustness.

Pharmaceutical Research

Pharmaceutical laboratories use Deuterated Vinyl Acetate-d6 during analytical method development, validation, impurity analysis, and stability testing. It supports regulatory-compliant quantitative workflows by improving method accuracy and reproducibility throughout product development.

Environmental Monitoring

Vinyl acetate is monitored in workplace air, industrial emissions, water samples, and environmental matrices. Deuterated Vinyl Acetate-d6 serves as a reliable recovery standard during environmental analysis, helping compensate for sample preparation losses and instrumental variability.

Isotope Tracing Studies

Researchers utilize isotopically labelled vinyl acetate to investigate reaction mechanisms, degradation pathways, metabolic transformations, and isotope exchange processes. Because deuterium minimally alters chemical reactivity, Vinyl Acetate-d6 provides valuable mechanistic insight while remaining analytically distinguishable from the native compound.

Advantages of Deuterated Vinyl Acetate-d6

Using a deuterated internal standard offers numerous analytical advantages over conventional calibration methods:

• Excellent correction for sample preparation variability
• Improved quantitative accuracy in LC-MS and GC-MS methods
• Reduced matrix effects during complex sample analysis
• Enhanced precision and reproducibility
• Better inter-laboratory method consistency
• Reliable isotope dilution quantification
• Support for regulatory analytical validation
• Compatibility with pharmaceutical, environmental, and industrial testing workflows

These benefits make Vinyl Acetate-d6 an essential analytical standard for laboratories requiring high-confidence quantitative measurements.

Role in Mass Spectrometry

Mass spectrometry relies heavily on stable isotope-labelled compounds to achieve highly accurate quantitative data. During isotope dilution analysis, the deuterated analogue is introduced into the sample at a known concentration before extraction. Since the labelled and unlabeled molecules experience nearly identical analytical conditions, differences caused by extraction losses, ion suppression, or detector fluctuations can be effectively corrected.

The predictable mass difference generated by six incorporated deuterium atoms allows clear distinction between the analyte and internal standard without significantly changing chromatographic retention. This characteristic substantially improves confidence in quantitative measurements across pharmaceutical, environmental, forensic, and industrial analytical workflows.

Typical Research Areas

Deuterated Vinyl Acetate-d6 is commonly employed in:

• Pharmaceutical analytical research
• Stable isotope dilution assays
• LC-MS/MS method development
• GC-MS quantitative analysis
• Environmental contaminant monitoring
• Chemical process validation
• Polymer chemistry research
• Analytical reference standard development
• Method validation studies
• Academic and industrial research laboratories

Quality Standards at ResolveMass Laboratories Inc.

ResolveMass Laboratories Inc. supplies isotope-labelled reference standards manufactured to meet the demanding requirements of analytical laboratories worldwide. Our Deuterated Vinyl Acetate-d6 is produced with emphasis on isotopic enrichment, chemical purity, identity verification, and batch-to-batch consistency. Each material undergoes rigorous quality assessment before release, ensuring dependable analytical performance for research and regulated laboratory applications.

Our experienced scientific team also supports custom synthesis of stable isotope-labelled compounds, analytical reference standards, and specialized deuterated molecules for pharmaceutical, biotechnology, environmental, and academic research.

Why Choose ResolveMass Laboratories Inc.?

Researchers choose ResolveMass Laboratories Inc. because we provide:

• High-purity stable isotope-labelled compounds
• Reliable batch consistency
• Comprehensive analytical characterization
• Support for pharmaceutical and biotechnology research
• Expertise in custom isotope-labelled synthesis
• Fast global supply for research laboratories
• Responsive scientific and technical support
• Commitment to quality, accuracy, and customer satisfaction

Whether your laboratory is developing quantitative LC-MS methods, validating analytical procedures, conducting environmental monitoring, or performing isotope tracing experiments, Deuterated Vinyl Acetate-d6 (CAS 189765-98-8) offers the accuracy, reproducibility, and analytical reliability required for modern scientific research.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals

PubChem CID: 102602259