Dimethylamine-d6 HCl | CAS 53170-19-7

OVERVIEW  of  Dimethylamine-d6 HCl | CAS 53170-19-7

Dimethylamine-d₆ hydrochloride (CAS 53170-19-7) is a fully deuterated analog of dimethylamine hydrochloride, where all six hydrogen atoms of the methyl groups are replaced by deuterium. This compound is primarily used as an isotopically labeled reagent in analytical, biochemical, and pharmaceutical research. Its deuterium labeling makes it valuable for NMR spectroscopy, mass spectrometry (MS) internal standardization, and kinetic isotope effect studies. In hydrochloride salt form, it is more stable and easier to handle compared to its gaseous free-base counterpart.

CHEMICAL INFORMATION

• Name: Dimethylamine-d₆ hydrochloride

• Molecular Formula: C₂D₆N·HCl

• Molecular Weight: 87.58 g/mol

• CAS Number: 53170-19-7

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated aliphatic amine salt

• Solubility: Freely soluble in water, methanol, and ethanol

APPLICATIONS  of  Dimethylamine-d6 HCl | CAS 53170-19-7

• NMR Spectroscopy:
  Acts as a deuterated amine standard or solvent additive in NMR studies, minimizing proton interference and improving spectral interpretation for amine-containing systems.

• Mass Spectrometry (MS):
  Commonly used as an internal standard or reference compound for quantitative analysis in LC-MS and GC-MS applications, due to its stable isotope-labeled profile and predictable fragmentation pattern.

• Kinetic Isotope Effect Studies:
  Utilized in mechanistic and kinetic research to investigate reaction rates and hydrogen transfer phenomena, leveraging the isotopic mass difference of deuterium.

• Pharmaceutical and Biochemical Research:
  Employed as a precursor in the synthesis of deuterated drug intermediates and metabolites, enhancing tracing accuracy in pharmacokinetic and metabolic studies.

ADVANTAGES  of  Dimethylamine-d6 HCl | CAS 53170-19-7

• High isotopic purity ensures precise analytical results.

• Stable hydrochloride form allows for easy handling and weighing.

• Compatible with a wide range of analytical solvents.

• Ideal for isotope tracing and mechanistic chemistry research.

HANDLING AND SAFETY

• Handling Precautions: Avoid inhalation or contact with skin and eyes; handle in a fume hood.

• Protective Equipment: Use chemical-resistant gloves, safety goggles, and lab coat.

• Storage: Keep tightly closed under inert atmosphere in a cool, dry place.

• Stability: Stable under recommended conditions; hygroscopic when exposed to air.

• Disposal: Dispose of in accordance with institutional and local regulations for amine salts and isotopically labeled compounds.

SUMMARY
Dimethylamine-d₆ hydrochloride (CAS 53170-19-7) is a stable, high-purity deuterated amine salt essential for isotope labeling, NMR, and MS analyses. Its complete deuteration and solid-state stability make it an indispensable reagent for analytical chemistry, pharmaceutical development, and kinetic studies, ensuring accuracy and reproducibility in deuterium-based investigations.