OVERVIEW of DL-Leucine-d10 | CAS 29909-01-1
DL-Leucine-d10 (CAS 29909-01-1) is a fully deuterated, isotopically labeled form of DL-leucine containing ten deuterium atoms. As an essential branched-chain amino acid (BCAA), leucine plays a key role in protein synthesis, metabolic regulation, and cellular signaling pathways. The deuterated analog, DL-Leucine-d10, provides precise mass differentiation for advanced LC-MS and GC-MS analytical workflows, enabling accurate quantitation, metabolic tracing, and internal standardization in complex biological samples.
This compound is widely used in metabolomics, nutritional biochemistry, proteomics research, isotope-dilution mass spectrometry, and pharmaceutical development. ResolveMass Laboratories Inc. manufactures DL-Leucine-d10 under stringent purity and isotopic enrichment standards to support high-precision research and regulated laboratory environments.
CHEMICAL INFORMATION
Chemical Name: DL-Leucine-d10
Synonyms: d10-DL-Leucine; Perdeuterated leucine
CAS Number: 29909-01-1
Molecular Formula: C₆H₂D₁₀NO₂
Molecular Weight: 141.24 g/mol
Isotopic Enrichment: ≥98 atom % D
APPLICATIONS of DL-Leucine-d10 | CAS 29909-01-1
-
Metabolomics & Systems Biology: Ideal for tracing amino acid metabolism, BCAA turnover, and cellular energy pathways.
-
LC-MS/GC-MS Internal Standard: Enables accurate quantification of leucine in plasma, serum, urine, tissues, and cell extracts.
-
Proteomics Research: Supports peptide/protein quantitation and stable isotope labeling in mass spectrometry (SILAC and related methods).
-
Nutritional & Clinical Studies: Used in metabolic flux analysis for studying muscle metabolism, insulin response, and dietary supplementation.
-
Pharmaceutical Development: Aids in PK/PD studies, impurity profiling, and formulation analysis involving leucine derivatives.
-
Biochemical Research: Facilitates studies on protein synthesis regulation, mTOR pathway signaling, and metabolic disorders.
FEATURES & BENEFITS
-
High Deuterium Incorporation: Ensures excellent mass separation and clear isotopic resolution.
-
Structurally Equivalent to Native Leucine: Behaves identically in biological and chemical systems, enabling accurate comparative quantitation.
-
Exceptional Purity: Suitable for regulated laboratories, clinical workflows, and high-precision research.
-
Stable & Reliable: Maintains isotopic integrity during sample preparation and analysis.
-
Versatile Analytical Compatibility: Ideal for LC-MS, GC-MS (after derivatization), and NMR studies.
SUMMARY
DL-Leucine-d10 (CAS 29909-01-1) is a high-purity, perdeuterated amino acid designed for accurate mass spectrometric quantitation, metabolic pathway research, proteomics, and nutritional biochemical analysis. With ten deuterium atoms providing excellent isotopic separation, it supports high-precision LC-MS/GC-MS workflows across clinical, pharmaceutical, and academic research sectors.
Learn more about,
Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc.
ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis
How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada
How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab
Deuterium-Labelled Compounds — Synthesis, Applications & Ordering
Custom Synthesis of Deuterated Chemicals
Reviews
There are no reviews yet.