Ethylene glycol-d6 | CAS 15054-86-1

OVERVIEW  of  Ethylene glycol-d6 | CAS 15054-86-1

Ethylene glycol-d6 (CAS 15054-86-1) is a fully deuterated form of ethylene glycol, in which all six hydrogen atoms are replaced with deuterium. This isotopically labeled compound is primarily utilized as a stable isotope standard in NMR spectroscopy, mass spectrometry, and tracer studies. Owing to its chemical identity with non-deuterated ethylene glycol, it serves as an ideal reference material for metabolic research, hydrogen–deuterium exchange experiments, and isotopic quantification. The high isotopic purity of Ethylene glycol-d6 ensures minimal background interference, providing precise analytical results.

CHEMICAL INFORMATION

• Name: Ethylene glycol-d6

• Molecular Formula: C₂D₆O₂

• Molecular Weight: 68.10 g/mol

• CAS Number: 15054-86-1

• Isotopic Labeling: Fully deuterated (six deuterium atoms)

• Chemical Class: Deuterated diol; stable isotope-labeled compound

• Stability: Stable under ambient conditions; hygroscopic in nature

APPLICATIONS  of  Ethylene glycol-d6 | CAS 15054-86-1

• NMR Spectroscopy:
  Used as a deuterated standard or solvent for ¹H and ²H NMR analyses, minimizing proton background and improving signal clarity in complex mixtures.

• Mass Spectrometry (MS):
  Functions as a stable isotope-labeled internal standard for quantitative determination of ethylene glycol and other polyols in biochemical and environmental samples.

• Tracer and Metabolic Studies:
  Employed in metabolic flux analysis and bio-distribution studies to trace the oxidation and degradation pathways of ethylene glycol and its metabolites.

• Kinetic Isotope Effect (KIE) Studies:
  Useful for evaluating reaction mechanisms and hydrogen/deuterium exchange kinetics in chemical and biochemical systems.

• Calibration & Standardization:
  Serves as a reference compound for isotopic calibration and quantitative analytical procedures in research laboratories.

ADVANTAGES  of  Ethylene glycol-d6 | CAS 15054-86-1

• Fully deuterated (≥ 98 atom % D) ensuring exceptional isotopic enrichment.

• Provides minimal proton interference in NMR and MS applications.

• Chemically equivalent to native ethylene glycol, ensuring consistent reaction behavior.

• High thermal and chemical stability for long-term storage and usage.

• Non-radioactive, safe, and compatible with a wide range of analytical instruments.

HANDLING, STORAGE & SAFETY

• Handling: Handle under dry conditions; avoid contact with strong oxidizing agents.

• Storage: Keep sealed in a cool (2–8 °C), dry, and dark environment.

• Safety: May cause mild skin or eye irritation; handle using appropriate protective equipment.

• Disposal: Dispose of according to institutional chemical waste management protocols.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Physical State: Viscous liquid

• Analytical Verification: Confirmed by ¹H NMR, ²H NMR, and mass spectrometry

• Documentation: Certificate of Analysis (CoA) provided with each batch

SUMMARY
Ethylene glycol-d6 (CAS 15054-86-1) is a fully deuterated isotopologue of ethylene glycol widely used in spectroscopic, analytical, and metabolic research. Its high isotopic purity ensures precise quantitative and qualitative analysis in NMR and MS applications. As a stable, non-radioactive reagent, Ethylene glycol-d6 is an essential material for advanced isotopic studies, metabolic pathway investigations, and reaction mechanism elucidation in both academic and industrial research settings.