Fenitrothion-d6 | CAS 203645-59-4

OVERVIEW  of  Fenitrothion-d6 | CAS 203645-59-4

Fenitrothion-d6 is a fully characterized isotope-labeled analog of Fenitrothion, a broad-spectrum organophosphate insecticide widely used in agricultural and vector control applications. The introduction of six deuterium atoms provides a mass increment that allows analytical distinction between the native compound and its labeled standard without altering physicochemical behavior.

At ResolveMass Laboratories Inc., Fenitrothion-d6 is synthesized through advanced deuteration and purification processes to achieve high isotopic and chemical purity. It serves as an essential reference standard for quantitative analysis and method validation in pesticide monitoring, environmental fate assessments, and metabolite identification.

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SUMMARY
Fenitrothion-d6 (CAS 203645-59-4) is a deuterium-labeled organophosphate insecticide analog, designed for use as an internal standard and reference compound in analytical, toxicological, and environmental studies. By substituting six hydrogen atoms with deuterium, this stable isotope-labeled compound enables precise quantification and tracking of Fenitrothion in complex matrices using gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–mass spectrometry (LC-MS). Supplied by ResolveMass Laboratories Inc., Fenitrothion-d6 offers high isotopic enrichment, ≥99% purity, and exceptional stability, ensuring reproducible analytical results in pesticide residue testing, degradation studies, and regulatory compliance programs.

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CHEMICAL INFORMATION

• Chemical Name: Fenitrothion-d6

• Synonyms: O,O-Dimethyl O-(3-methyl-4-nitrophenyl)-phosphorothioate-d6; Deuterated Fenitrothion

• CAS Number: 203645-59-4

• Molecular Formula: C₉H₈D₆NO₅PS

• Molecular Weight: 283.27 g/mol

• Isotopic Enrichment: ≥ 98 atom % D

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DESCRIPTION AND PROPERTIES
Fenitrothion-d6 mirrors the chemical and physical characteristics of its non-deuterated counterpart while offering an isotopic mass difference for differentiation during spectrometric analysis. It is particularly useful in isotope dilution mass spectrometry (IDMS), where it compensates for sample preparation and matrix effects, ensuring quantitative precision.

This compound is stable under standard storage conditions, with minimal isotopic exchange or degradation, and provides consistent chromatographic retention and ionization characteristics comparable to native Fenitrothion. Its reliability and stability make it an indispensable analytical standard in both research and regulatory testing laboratories.

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APPLICATIONS  of  Fenitrothion-d6 | CAS 203645-59-4

1. Pesticide Residue Analysis:
   Fenitrothion-d6 is widely employed as an internal standard in GC-MS and LC-MS/MS analyses to quantify trace levels of Fenitrothion residues in agricultural produce, soil, and water samples. Its isotopic differentiation allows accurate correction for matrix effects and instrument variability.

2. Environmental Monitoring:
   Used in studies evaluating the environmental fate of organophosphate pesticides, Fenitrothion-d6 helps track degradation, hydrolysis, and photolysis pathways under controlled and field conditions.

3. Isotope Dilution Mass Spectrometry (IDMS):
   As a stable isotope-labeled analog, Fenitrothion-d6 serves as a calibration and quantitation standard, improving analytical accuracy and reproducibility in pesticide testing programs.

4. Toxicokinetic and Metabolism Studies:
   In toxicological research, Fenitrothion-d6 assists in tracing metabolic transformations and identifying degradation intermediates or conjugates in biological and environmental matrices.

5. Analytical Method Validation:
   Analytical laboratories use Fenitrothion-d6 to validate new methods for detecting organophosphate residues, ensuring compliance with regulatory frameworks such as EPA, EFSA, and ISO standards.

6. Quality Control and Proficiency Testing:
   Its defined isotopic labeling makes it suitable for use in interlaboratory comparisons, calibration of reference materials, and performance verification of analytical systems.

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ANALYTICAL ADVANTAGES

• Precise isotopic labeling for accurate mass differentiation

• Excellent stability and low volatility under analytical conditions

• Ideal for GC-MS, GC-MS/MS, and LC-MS/MS quantification

• Chemically and physically equivalent to Fenitrothion

• Enhances data reproducibility and traceability

• Suitable for compliance testing and reference material preparation

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QUALITY AND MANUFACTURING
At ResolveMass Laboratories Inc., Fenitrothion-d6 is produced through advanced deuterium incorporation techniques using high-purity precursors and controlled reaction conditions. Each batch undergoes comprehensive quality control testing, including GC-MS, LC-MS, and NMR spectroscopy, to verify isotopic enrichment, purity, and structural integrity.

Our rigorous manufacturing standards align with international analytical reference material guidelines, ensuring that every lot of Fenitrothion-d6 provides reproducible and traceable analytical results. The compound’s high isotopic fidelity and low impurity profile make it the preferred standard for pesticide residue monitoring and environmental risk assessment laboratories.

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CONCLUSION
Fenitrothion-d6 is a high-purity, stable isotope-labeled organophosphate analog designed to support advanced analytical, toxicological, and environmental studies. Its precise isotopic composition, exceptional stability, and chemical equivalence to native Fenitrothion make it indispensable for accurate quantification and method validation in modern pesticide residue analysis.

Offered by ResolveMass Laboratories Inc., Fenitrothion-d6 embodies analytical reliability and quality assurance, delivering consistent performance for researchers, regulatory authorities, and quality control laboratories engaged in pesticide and environmental monitoring.

 

 

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