Fenthion-d6 | CAS 1189662-83-6

OVERVIEW  of  Fenthion-d6 | CAS 1189662-83-6

Fenthion-d6 serves as the stable isotope-labeled analog of Fenthion, an organophosphate insecticide used to control a wide range of agricultural and public health pests. The incorporation of six deuterium atoms provides a predictable mass shift, enabling accurate differentiation from the non-labeled compound during spectrometric detection without altering chromatographic or chemical behavior.

At ResolveMass Laboratories Inc., Fenthion-d6 is produced under stringent isotopic labeling and purification protocols to ensure consistent isotopic enrichment and low background contamination. It is particularly valuable for laboratories performing pesticide residue testing, metabolism studies, and environmental degradation analyses where trace quantification and validation are essential.

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CHEMICAL INFORMATION

• Chemical Name: Fenthion-d6

• Synonyms: O,O-Dimethyl O-(3-methyl-4-(methylthio)phenyl) phosphorothioate-d6; Deuterated Fenthion

• CAS Number: 1189662-83-6

• Molecular Formula: C₁₀H₆D₆O₃PS₂

• Molecular Weight: 284.36 g/mol

• Isotopic Enrichment: ≥ 99 atom % D

• Chemical Class: Organophosphate insecticide analog

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DESCRIPTION AND PROPERTIES
Fenthion-d6 retains all the essential physicochemical properties of native Fenthion while offering a +6 Da isotopic mass difference for clear identification in mass spectrometric analyses. Its stability, isotopic accuracy, and chemical equivalence make it an ideal internal standard for quantitative analyses of Fenthion residues and degradation products in environmental and biological matrices.

The compound is non-radioactive, safe to handle under standard laboratory conditions, and exhibits negligible isotopic exchange under appropriate storage. Its reliable chromatographic retention and ionization behavior ensure reproducible quantification across diverse sample types including crops, soils, animal tissues, and water systems.

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APPLICATIONS  of  Fenthion-d6 | CAS 1189662-83-6

1. Pesticide Residue Quantification:
   Fenthion-d6 is primarily used as an internal standard in GC-MS and LC-MS/MS assays to determine Fenthion residues in agricultural produce, animal tissues, and environmental samples. Its mass difference enables precise isotope dilution quantification even at trace levels.

2. Environmental Fate and Degradation Studies:
   The compound serves as a tracer in studies assessing Fenthion’s degradation pathways, hydrolysis rates, and photolytic behavior under different environmental conditions.

3. Toxicokinetic and Metabolism Research:
   Fenthion-d6 is employed to study metabolic conversion, absorption, and elimination mechanisms in biological systems, providing insights into organophosphate metabolism and detoxification.

4. Method Validation and Quality Control:
   Analytical laboratories utilize Fenthion-d6 for validating and standardizing quantitative methods in compliance with regulatory frameworks established by EPA, EFSA, and ISO pesticide monitoring protocols.

5. Isotope Dilution Mass Spectrometry (IDMS):
   Due to its isotopic precision and chemical equivalence, Fenthion-d6 is a preferred calibration material for IDMS, reducing measurement uncertainty and enhancing analytical reliability.

6. Proficiency Testing and Calibration:
   Fenthion-d6 serves as a benchmark in interlaboratory testing and instrument calibration to ensure consistency, reproducibility, and traceability in pesticide testing workflows.

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ANALYTICAL ADVANTAGES

• Precisely defined isotopic composition (+6 Da mass shift)

• Chemically identical to native Fenthion for accurate internal standardization

• Ideal for GC-MS, GC-MS/MS, and LC-MS/MS quantitation

• Excellent isotopic and thermal stability under analysis conditions

• Enhances precision and reduces matrix effect variability

• Meets global analytical and regulatory quality standards

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QUALITY AND MANUFACTURING
At ResolveMass Laboratories Inc., Fenthion-d6 is synthesized via controlled deuterium incorporation into selected precursor molecules, ensuring full isotopic labeling and high purity. Each batch undergoes multi-point analytical verification using GC-MS, LC-MS, and NMR spectroscopy to confirm isotopic enrichment, chemical identity, and chromatographic performance.

Our manufacturing adheres to rigorous quality control standards equivalent to international reference material specifications. The result is a consistently reliable isotope-labeled product that meets the demands of advanced analytical laboratories engaged in regulatory pesticide testing, research, and environmental monitoring.

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CONCLUSION
Fenthion-d6 is a high-quality deuterium-labeled organophosphate analog designed for precise quantification, method validation, and research in pesticide residue and environmental analysis. With its superior isotopic enrichment, chemical purity, and batch-to-batch reproducibility, it provides an indispensable analytical tool for laboratories committed to accurate and traceable measurements.

Supplied by ResolveMass Laboratories Inc., Fenthion-d6 supports the highest standards of analytical excellence, ensuring dependable results for research institutions, regulatory agencies, and environmental testing laboratories worldwide.

 

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