Fluorobenzene-d5 | CAS 1423-10-5

OVERVIEW  of  Fluorobenzene-d5 | CAS 1423-10-5

 
Fluorobenzene-d5 is a key deuterated aromatic compound widely used in analytical and synthetic chemistry. The introduction of five deuterium atoms offers a mass difference of +5 Da compared to the non-deuterated fluorobenzene, without altering its physicochemical behavior.

This compound is highly valued for its role as a deuterated solvent reference in NMR spectroscopy and as a mass spectrometric internal standard for isotopic quantification and tracer studies. The compound’s stable C–D bonds and non-exchangeable deuterium atoms make it particularly suitable for high-precision isotope dilution and mechanistic investigations.

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CHEMICAL INFORMATION

• Chemical Name: Fluorobenzene-d5

• Synonyms: Deuterated fluorobenzene; C6D5F

• CAS Number: 1423-10-5

• Molecular Formula: C6D5F

• Molecular Weight: 101.13 g/mol

• Isotopic Enrichment: ≥ 99 atom % D

• Purity: ≥ 99%

• Chemical Class: Deuterated aromatic hydrocarbon

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DESCRIPTION AND PROPERTIES
Fluorobenzene-d5 is a stable, non-reactive, and volatile aromatic compound that closely mimics the chemical behavior of fluorobenzene while exhibiting an isotopic mass shift suitable for analytical distinction. Its deuterium atoms are located at non-exchangeable positions, maintaining stability during chromatographic and spectroscopic analyses.

Due to its low reactivity and favorable volatility, Fluorobenzene-d5 is commonly employed as a reference solvent in ^19F and ^1H NMR spectroscopy. Its spectral simplicity and well-resolved chemical shifts make it ideal for calibration and background suppression in high-precision NMR studies.

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APPLICATIONS  of  Fluorobenzene-d5 | CAS 1423-10-5 

1. NMR Spectroscopy Solvent Standard:
   Commonly used as a reference solvent in ^1H and ^19F NMR studies for calibration, background signal suppression, and quantitative spectral interpretation.

2. Mass Spectrometry Internal Standard:
   Serves as a stable isotopic standard for GC-MS and LC-MS applications, particularly in aromatic compound analysis and quantitative isotope ratio studies.

3. Tracer in Chemical Kinetics:
   Utilized in reaction kinetics and isotopic effect investigations to study aromatic substitution mechanisms and reaction pathways.

4. Pharmaceutical and Environmental Research:
   Functions as a control and calibration standard in the analysis of volatile organic compounds (VOCs), fluorinated aromatics, and related pollutants.

5. Synthetic and Mechanistic Chemistry:
   Acts as a labeled substrate in fluorination reaction studies and isotope effect experiments to evaluate substitution dynamics and reaction mechanisms.

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ANALYTICAL ADVANTAGES

• Fully deuterated aromatic ring (C6D5F) for clear isotopic mass separation (+5 Da)

• Non-exchangeable deuterium atoms ensure stable isotopic labeling

• Ideal as an NMR reference solvent and MS internal standard

• Chemically identical to native fluorobenzene for consistent chromatographic behavior

• High isotopic enrichment and analytical-grade purity

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QUALITY AND MANUFACTURING
At ResolveMass Laboratories Inc., Fluorobenzene-d5 is synthesized under strictly controlled isotopic conditions to ensure high deuterium incorporation and minimal proton contamination. Each batch is verified by NMR spectroscopy, GC-MS, and FTIR to confirm isotopic enrichment, purity, and structural identity.

Our rigorous quality assurance process guarantees reproducibility and analytical accuracy, supporting applications in regulated environments including pharmaceuticals, reference laboratories, and research institutions.

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CONCLUSION
Fluorobenzene-d5 (CAS 1423-10-5) is a highly stable, fully deuterated aromatic compound designed for accurate analytical, synthetic, and spectroscopic research. Its isotopic precision, reproducibility, and purity make it an indispensable standard for NMR solvent referencing, GC-MS quantification, and isotopic tracer studies.

Available from ResolveMass Laboratories Inc., Fluorobenzene-d5 exemplifies analytical excellence and reliability—supporting high-precision isotope labeling and advanced chemical analysis across diverse research domains.

 

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