Gabapentin-d4 | CAS 1185039-20-6

OVERVIEW  of  Gabapentin-d4 | CAS 1185039-20-6

Gabapentin-d4 (CAS 1185039-20-6) is a deuterium-labeled analog of Gabapentin, a well-known anticonvulsant and neuropathic pain medication. This isotopically labeled compound incorporates four deuterium atoms, providing superior stability and precise mass differentiation for LC-MS/MS quantitative analysis, pharmacokinetic (PK) profiling, and bioanalytical method validation. The structural similarity to the native drug ensures identical chemical behavior while allowing for accurate detection and quantitation through isotopic mass separation.

At ResolveMass Laboratories Inc., Gabapentin-d4 is synthesized with exceptional isotopic enrichment and chemical purity, offering a dependable internal standard for regulated bioanalysis and research in pharmaceutical development.

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CHEMICAL INFORMATION

• Chemical Name: Gabapentin-d4

• Synonyms: 1-(Aminomethyl)-cyclohexaneacetic acid-d4, Deuterated Gabapentin

• CAS Number: 1185039-20-6

• Molecular Formula: C₉H₉D₄NO₂

• Molecular Weight: 177.25 g/mol

• Isotopic Labeling: d₄

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APPLICATIONS  of  Gabapentin-d4 | CAS 1185039-20-6

• Bioanalytical Internal Standard: Extensively used in LC-MS/MS quantification of Gabapentin in biological fluids such as plasma, serum, and urine for pharmacokinetic and bioequivalence studies.

• Pharmaceutical Development: Supports drug metabolism, stability, and bioavailability investigations by providing a stable isotopic reference compound.

• Forensic and Clinical Research: Utilized for toxicology analysis and therapeutic drug monitoring to ensure accurate measurement of Gabapentin concentrations.

• Method Validation: Enhances analytical accuracy and reproducibility in regulated bioanalytical method validation under FDA/EMA guidelines.

• Quality Control Studies: Serves as a benchmark compound for assessing analytical precision and matrix effect correction.

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FEATURES & BENEFITS

• High Isotopic Purity: Ensures reliable isotope ratio measurements and eliminates interferences during LC-MS/MS analysis.

• Stable and Reproducible: Chemically and isotopically stable for extended storage and analytical applications.

• Pharmaceutical-Grade Quality: Synthesized under stringent laboratory conditions with validated purification processes.

• Ideal for Regulatory Studies: Meets bioanalytical requirements for GxP-compliant laboratories performing clinical and preclinical research.

• Custom Labeling Available: ResolveMass Laboratories provides tailored synthesis of Gabapentin isotopologues and analogs for specific research needs.

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SUMMARY
Gabapentin-d4 (CAS 1185039-20-6) is a high-purity deuterium-labeled internal standard specifically designed for quantitative LC-MS/MS analysis of Gabapentin in pharmacokinetic, clinical, and toxicological studies. Its isotopic stability and structural equivalence to the parent compound ensure consistent analytical performance, making it essential for regulated bioanalytical laboratories. Produced by ResolveMass Laboratories Inc., Gabapentin-d4 supports cutting-edge research in drug development, validation, and quality assurance.

 

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PubChem CID	3446