Glycine-2,2-d2-N-Fmoc | CAS 284665-11-8

OVERVIEW  of  Glycine-2,2-d2-N-Fmoc | CAS 284665-11-8

Glycine-2,2-d2-N-Fmoc (CAS 284665-11-8) is a deuterium-labeled, N-fluorenylmethyloxycarbonyl (Fmoc) protected glycine derivative, designed specifically for solid-phase peptide synthesis (SPPS) and isotopic labeling applications. With two deuterium atoms incorporated at the 2-position, this compound provides a distinct mass shift ideal for LC-MS peptide quantification, proteomics, metabolic pathway studies, and bioanalytical assay development. The Fmoc protecting group allows for highly efficient peptide coupling under mild, base-labile deprotection conditions.

At ResolveMass Laboratories Inc., Glycine-2,2-d2-N-Fmoc is produced with high isotopic and chemical purity, ensuring reliable performance in research-grade peptide synthesis, isotope-dilution mass spectrometry, and structural biology applications. It is particularly useful for creating deuterated peptide fragments, internal standards, and labeled analogs for mechanistic and quantitative studies.

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CHEMICAL INFORMATION

• Chemical Name: Glycine-2,2-d2-N-Fmoc

• Synonyms: Fmoc-Glycine-d2, N-Fmoc-2,2-d2-glycine, Deuterated Fmoc-glycine

• CAS Number: 284665-11-8

• Molecular Formula: C₁₈H₁₄D₂NO₄

• Molecular Weight: 313.34 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Protecting Group: Fluorenylmethyloxycarbonyl (Fmoc)

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APPLICATIONS  of  Glycine-2,2-d2-N-Fmoc | CAS 284665-11-8

• Peptide Synthesis (SPPS): A key building block for assembling deuterium-labeled peptides, enabling mass spectrometry-based quantification and structural analysis.

• Proteomics Research: Supports the development of isotope-labeled peptide standards for targeted proteomics workflows such as MRM, PRM, and DIA.

• Isotope-Dilution Mass Spectrometry (IDMS): Enhances quantitation accuracy in LC-MS assays by providing a stable internal standard with predictable mass separation.

• Metabolic Pathway & Flux Studies: Assists in tracing glycine incorporation into proteins, metabolic intermediates, and biochemical pathways.

• Pharmaceutical Development: Useful in designing labeled peptide drugs, studying metabolic stability, and evaluating drug–protein interactions.

• Structural Biology: Enables preparation of deuterated peptides for NMR-based conformational studies and protein–ligand interaction mapping.

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FEATURES & BENEFITS

• High Deuterium Stability: Maintains isotopic labeling during typical SPPS and coupling reactions.

• Fmoc Compatibility: Fully compatible with automated SPPS strategies and widely used peptide coupling reagents.

• Chemically & Isotopically Pure: Ensures consistent yields, clean chromatographic profiles, and reliable MS signals.

• Versatile Research Utility: Suitable for proteomics, metabolomics, pharmaceutical R&D, and structural analysis.

• Ideal for MS-Based Quantitation: Provides clear mass separation from unlabeled glycine-containing peptides.

• Custom Synthesis Available: ResolveMass Laboratories offers Fmoc-protected amino acids with various labeling patterns tailored to specific research needs.

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SUMMARY
Glycine-2,2-d2-N-Fmoc (CAS 284665-11-8) is a high-purity, isotopically labeled amino acid derivative designed for SPPS, proteomics, and advanced analytical applications. Containing two deuterium atoms at the 2-position and an Fmoc-protected amine, this compound supports the synthesis of deuterated peptides, LC-MS internal standards, and metabolic probes. Produced by ResolveMass Laboratories Inc., it offers excellent chemical stability, high isotopic enrichment, and consistent performance for researchers in biochemistry, analytical chemistry, and pharmaceutical sciences.

 

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