Isophthalic-2,4,5,6-d4 Acid | CAS 148472-48-4

OVERVIEW  of  Isophthalic-2,4,5,6-d4 Acid | CAS 148472-48-4

Isophthalic-2,4,5,6-d₄ Acid is a selectively deuterated analogue of isophthalic acid, an important aromatic dicarboxylic acid widely used in polymer chemistry, material science, and structural analysis of aromatic systems. By incorporating four deuterium atoms into the benzene ring, this labeled compound provides a clear and predictable mass shift that is ideal for isotope-dilution studies, mechanistic assessments, material tracing, and advanced analytical characterization.

The compound preserves the fundamental chemical reactivity, functional group behavior, and solubility profile of native isophthalic acid while offering enhanced detectability and analytical discrimination in mass spectrometric workflows. Its high isotopic enrichment ensures precise quantification and reproducibility, making it a valuable resource for research laboratories, material developers, and analytical chemists working with aromatic polymers, degradation products, and environmental residues.

Isophthalic-2,4,5,6-d₄ Acid demonstrates high stability, excellent batch consistency, and compatibility with chromatographic and spectrometric techniques, making it a reliable standard for structural elucidation and quantitative analysis.

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CHEMICAL INFORMATION

• Name: Isophthalic-2,4,5,6-d₄ Acid

• CAS Number: 148472-48-4

• Molecular Formula: C₈H₂D₄O₄

• Molecular Weight: 170.16 g/mol

• Isotopic Enrichment: Typically ≥98% D

• Functional Groups: Aromatic ring, two carboxylic acid groups

• Stability: Highly stable under ambient laboratory conditions

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APPLICATIONS  of  Isophthalic-2,4,5,6-d4 Acid | CAS 148472-48-4
Isophthalic-2,4,5,6-d₄ Acid is a versatile isotopically labeled compound with diverse research and analytical applications:

• Isotope-Dilution Mass Spectrometry (IDMS):
  Enables precise quantitative analysis of isophthalic acid in polymers, coatings, adhesives, and environmental samples.

• Polymer and Material Research:
  Used in studies investigating polymer degradation, monomer tracing, crosslinking behavior, diffusion mechanisms, and long-term material stability.

• Structural and Mechanistic Studies:
  Deuteration aids in NMR spectral simplification, kinetic isotope effect studies, and mechanistic investigations involving aromatic substitution or oxidation pathways.

• Environmental & Industrial Monitoring:
  Supports detection and quantification of isophthalic acid residues in soils, wastewater, industrial effluents, and recycled materials.

• Quality Control & Method Validation:
  Serves as a reference material for calibration, recovery studies, instrument performance verification, and reproducibility assessment across GC-MS, LC-MS, and FT-IR workflows.

• Advanced Analytical Research:
  Provides mass-shift clarity for high-resolution instruments such as Orbitrap and TOF systems, ensuring clean spectral separation from native components.

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ADVANTAGES  of  Isophthalic-2,4,5,6-d4 Acid | CAS 148472-48-4

• Distinct Mass Shift for Reliable Quantification:
  Four deuterium atoms provide clean isotopic separation without altering the chemical behavior of the parent compound.

• Excellent Chemical and Thermal Stability:
  Suitable for long-term storage and stable through standard analytical workflows.

• High Reproducibility:
  Supports consistent recovery and calibration across diverse matrices and analytical platforms.

• Ideal for Multi-Technique Compatibility:
  Performs robustly in LC-MS, GC-MS (after derivatization), NMR, FT-IR, and polymer analytical methods.

• Reduces Matrix-Associated Variability:
  Enhances accuracy in complex environmental or industrial sample matrices.

• Supports Mechanistic Insight:
  Deuteration allows researchers to track reaction pathways, distinguish isotopic fragments, and study subtle kinetic phenomena.

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SUMMARY
Isophthalic-2,4,5,6-d₄ Acid is an essential deuterated aromatic dicarboxylic acid designed for analytical accuracy, material research, and mechanistic chemistry. With four strategically incorporated deuterium atoms, it provides strong isotopic contrast in mass spectrometry, enabling precise quantification and high-resolution tracking of isophthalic acid in complex systems. Its structural fidelity, chemical stability, and compatibility with advanced analytical techniques make it indispensable for laboratories engaged in polymer science, environmental analysis, and high-precision chemical research. For organizations requiring reliable isotope-labeled standards, Isophthalic-2,4,5,6-d₄ Acid offers exceptional clarity, reproducibility, and analytical performance.

 

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