m-Cresol-d7, OD | CAS 202325-51-7

m-Cresol-d₇, OD | CAS No.: 202325-51-7

Molecular Formula: C₇D₇OD
Molecular Weight: 115.18 g/mol
Synonyms: 3-Methylphenol-d₇, m-Methylphenol-d₇, m-Hydroxytoluene-d₇, m-Cresol-d₇ isotopic standard, Deuterated m-cresol, m-Cresol-D7 (OD form), 3-Methylphenol-D7, Perdeutero-m-cresol

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Product Overview

m-Cresol-d₇, OD is a stable isotope-labeled analog of m-cresol (3-methylphenol) in which all seven hydrogen atoms on the aromatic ring and methyl group are replaced by deuterium (²H or D), and the hydroxyl group exists in its OD (deuterated hydroxyl) form. This high-purity deuterated phenolic compound serves as an internal standard for quantitative analysis, analytical method validation, and mechanistic studies in pharmaceutical, environmental, and chemical research.

The OD form minimizes hydrogen exchange, improving isotopic stability during storage and analysis. With chemical purity ≥99% and isotopic enrichment ≥98 atom % D, m-Cresol-d₇, OD is ideal for mass spectrometry (MS), nuclear magnetic resonance (NMR), and trace-level quantification of cresols in biological fluids, industrial samples, and formulations.

ResolveMass Laboratories Inc. provides high-quality deuterated standards designed to meet the stringent analytical requirements of pharmaceutical research, environmental monitoring, and metabolomics studies.

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Applications and Uses of m-Cresol-d7 OD | CAS 202325-51-7

1. Internal Standard for Mass Spectrometry

m-Cresol-d₇, OD is extensively employed as a stable isotope-labeled internal standard in GC-MS and LC-MS/MS for precise quantification of phenolic compounds.

• Provides a +7 Da mass shift, enabling unambiguous distinction from native m-cresol.

• Corrects for matrix effects, sample loss, and instrument variability, ensuring accurate trace-level analysis.

• Essential for pharmaceutical impurity profiling, metabolite quantification, and environmental monitoring of cresols.

2. Metabolomics and Clinical Studies

m-Cresol is a metabolic product of tyrosine and other aromatic amino acids. In clinical metabolomics, m-Cresol-d₇, OD allows:

• Absolute quantification of m-cresol in biological fluids like plasma, urine, or serum.

• Assessment of metabolic dysregulation and gut microbiota activity.

• Monitoring of uremic toxins and other phenolic metabolites relevant in kidney dysfunction and systemic diseases.

3. NMR Spectroscopy and Isotope Labeling

Fully deuterated m-Cresol-d₇, OD serves as a non-protonated NMR reference or solvent for advanced spectroscopic studies:

• OD substitution prevents proton exchange, improving spectral clarity and quantitative reliability.

• Useful for studying hydrogen bonding, isotope effects, and aromatic proton environments in organic chemistry.

4. Environmental and Industrial Applications

m-Cresol is a common industrial contaminant in chemical and resin production. The deuterated form is used to:

• Track phenolic contaminants in environmental matrices.

• Conduct tracer studies for degradation pathways, bioaccumulation, and partitioning behavior.

• Assess biodegradation rates and environmental fate of cresols using isotope-labeled compounds.

5. Quality Control and Method Validation

m-Cresol-d₇, OD is a critical standard for analytical method development, system suitability, and validation:

• Ensures regulatory compliance during ICH-guided validation of pharmaceutical and food-grade products.

• Provides reliable internal standards for stability testing, impurity profiling, and batch-to-batch consistency analysis.

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Analytical Advantages of m-Cresol-d7 OD | CAS 202325-51-7

• High isotopic stability: OD group prevents exchange with protic solvents.

• Distinct mass shift: Facilitates differentiation from unlabeled compounds in MS assays.

• High purity: ≥99% chemical purity reduces interference and background signals.

• Versatile: Compatible with GC-MS, LC-MS/MS, FTIR, and NMR spectroscopy.

• Trace-level quantification: Accurate internal standard for ppb-level detection of m-cresol and related phenols.

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Storage and Handling

Store under an inert atmosphere (nitrogen or argon) in tightly sealed amber glass containers, at 2–8 °C. Avoid prolonged exposure to light, moisture, and heat. Handle with appropriate PPE, including gloves, goggles, and lab coats. Work in a well-ventilated area or fume hood.

ResolveMass Laboratories offers custom isotope labeling services and synthesis of deuterated, ¹³C, and ¹⁵N compounds, tailored to pharmaceutical and analytical applications.

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Conclusion

m-Cresol-d₇, OD (CAS No.: 202325-51-7) is a fully deuterated phenolic compound essential for analytical, metabolomic, and environmental studies. Its high isotopic stability, OD substitution, and chemical purity make it an indispensable tool for MS quantification, NMR spectroscopy, method validation, and tracer experiments.

At ResolveMass Laboratories Inc., we provide high-quality isotope-labeled standards with robust documentation and analytical support to ensure accuracy, reproducibility, and regulatory compliance in pharmaceutical and chemical research.