Malathion-d6 (dimethyl-d6) | CAS 1189877-72-2

OVERVIEW  of  Malathion-d6 (dimethyl-d6) | CAS 1189877-72-2
Malathion-d₆ (dimethyl-d₆) is a stable isotopically labeled analog of malathion, an organophosphate insecticide widely used in agricultural, veterinary, and public health applications. In this compound, the two methyl groups attached to the thiophosphate moiety are replaced with deuterium atoms, resulting in a total of six deuterium substitutions. This isotopic labeling increases the molecular weight by +6 Da compared to the non-deuterated malathion, without altering its chemical reactivity or biological properties.

Malathion-d₆ is primarily used as an analytical standard in mass spectrometry (MS) and chromatographic studies for accurate detection, quantification, and confirmation of malathion residues in complex biological and environmental matrices. It is also valuable in metabolic and degradation pathway investigations, where isotopic labeling facilitates the tracking of the compound’s transformation products.

CHEMICAL INFORMATION

• Name: Malathion-d₆xn

• Molecular Formula: C₁₀H₁₃D₆O₆PS₂

• Molecular Weight: 336.39 g/mol

• CAS Number: 1189877-72-2

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Organophosphate pesticide; deuterated analog

• Solubility: Slightly soluble in water; soluble in ethanol, acetone, and most organic solvents

APPLICATIONS  of  Malathion-d6 (dimethyl-d6) | CAS 1189877-72-2

• Mass Spectrometry & Chromatography:
  Malathion-d₆ is extensively used as an internal standard or surrogate compound in GC-MS and LC-MS/MS methods for quantifying malathion residues in environmental, agricultural, and biological samples. The +6 Da mass shift enables precise differentiation between native and labeled analytes.

• Environmental and Toxicological Studies:
  Serves as a tracer molecule to study the biodegradation, environmental fate, and metabolic pathways of malathion and related organophosphates.

• Metabolomics and Biomonitoring:
  Facilitates quantitative analysis of pesticide exposure in biological fluids such as blood and urine, providing accurate calibration for isotope dilution mass spectrometry.

• Quality Control in Agrochemical Formulations:
  Used in validation and performance testing of analytical instruments, ensuring reproducibility and accuracy in pesticide residue analysis.

ADVANTAGES  of  Malathion-d6 (dimethyl-d6) | CAS 1189877-72-2

• High isotopic enrichment (≥ 98 atom % D) ensures excellent signal separation in MS.

• Chemically identical to malathion, preserving analytical equivalence.

• Provides enhanced precision in isotope dilution and quantitative assays.

• Non-radioactive, stable, and safe isotope tracer alternative.

• Ideal for environmental residue and toxicological monitoring.

HANDLING, STORAGE & SAFETY

• Hazards: Malathion and its analogs are toxic by ingestion, inhalation, or dermal absorption. They act as cholinesterase inhibitors, leading to neurotoxic effects.

• Precautions: Handle only in a well-ventilated area or fume hood. Use gloves, safety goggles, and protective clothing. Avoid direct contact or inhalation.

• Storage: Store in tightly sealed containers under nitrogen or argon, away from heat, light, and moisture at 2–8 °C.

• Disposal: Dispose of in accordance with local environmental and hazardous waste regulations for organophosphates.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Verification Methods: Confirmed via GC-MS, LC-MS, and NMR spectroscopy (¹H and ²H NMR showing characteristic deuterium substitution).

• Physical State: Clear to light yellow liquid

• Documentation: Certificate of Analysis (CoA) provided with purity and isotopic data

SUMMARY
Malathion-d₆ (dimethyl-d₆) | CAS 1189877-72-2 is a deuterium-labeled organophosphate compound designed for high-precision analytical applications. Its stable isotopic composition and chemical equivalence to native malathion make it indispensable in quantitative mass spectrometry, environmental toxicology, and metabolic research. The compound provides accurate internal standardization in pesticide residue testing, offering superior reliability and reproducibility in analytical laboratories and environmental monitoring programs.

Learn more about,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 

How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 

How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 

Deuterium-Labelled Compounds — Synthesis, Applications & Ordering