Meso-Erythritol-1,1,2,3,4,4-d6 | CAS 2714435-98-8

OVERVIEW  of  Meso-Erythritol-1,1,2,3,4,4-d6 | CAS 2714435-98-8
Meso-Erythritol-1,1,2,3,4,4-d6 is a deuterated analog of erythritol — a naturally occurring sugar alcohol commonly used in metabolic and nutritional research. By selectively replacing six hydrogen atoms with deuterium, this compound provides a stable isotope label that enables scientists to track molecular transformations and quantify metabolic intermediates with exceptional precision.

At ResolveMass Laboratories Inc., Meso-Erythritol-1,1,2,3,4,4-d6 is synthesized under tightly controlled isotopic labeling conditions to ensure a deuterium enrichment of ≥98 atom % D. It is extensively characterized for chemical and isotopic purity, making it an indispensable internal standard and tracer in advanced mass spectrometry, NMR spectroscopy, and stable isotope-based metabolic flux analysis (MFA).

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SUMMARY
Meso-Erythritol-1,1,2,3,4,4-d6 (CAS 2714435-98-8) is a stable isotope-labeled sugar alcohol in which six hydrogen atoms are substituted with deuterium. This high-purity compound is primarily used in metabolic tracing, bioanalytical studies, and isotope-dilution mass spectrometry (IDMS). Manufactured by ResolveMass Laboratories Inc., this deuterated polyol provides excellent isotopic enrichment, structural integrity, and reproducibility for biochemical and pharmaceutical research, enabling precise quantification and pathway analysis in advanced metabolic investigations.

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CHEMICAL INFORMATION

• Chemical Name: Meso-Erythritol-1,1,2,3,4,4-d6

• Synonyms: Erythritol-d6; 1,1,2,3,4,4-Hexadeuterioerythritol; Erythritol-d6 (meso-form)

• CAS Number: 2714435-98-8

• Molecular Formula: C₄H₂D₆O₄

• Molecular Weight: 128.15 g/mol

• Isotopic Enrichment: ≥ 98 atom % D

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DESCRIPTION AND PROPERTIES
Meso-Erythritol-1,1,2,3,4,4-d6 is a tetrahydric alcohol that retains the same stereochemical and physicochemical properties as natural erythritol, except for the mass increase caused by deuterium substitution. The deuteration at multiple positions results in a +6 Da mass shift, which provides an easily distinguishable isotopic signature in mass spectrometric analysis without altering its chemical reactivity or polarity.

This compound’s inertness, high solubility, and stability make it a versatile internal standard for quantitative bioanalysis of sugar alcohols, carbohydrates, and related metabolic intermediates. It is also highly valuable in metabolic research where deuterium incorporation helps track energy pathways, carbon fluxes, and biosynthetic transformations.

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APPLICATIONS  of  Meso-Erythritol-1,1,2,3,4,4-d6 | CAS 2714435-98-8

1. Stable Isotope Tracer in Metabolic Studies:
   Meso-Erythritol-1,1,2,3,4,4-d6 is extensively used as a tracer in metabolic flux analysis and stable isotope labeling experiments. Its incorporation allows the study of carbohydrate metabolism, energy utilization, and biosynthetic pathway tracing in biological systems.

2. Internal Standard in Mass Spectrometry (MS):
   The distinct +6 Da mass shift makes it an ideal internal standard in GC-MS and LC-MS analyses, enabling highly accurate quantitation of erythritol and related polyols in complex biological matrices such as plasma, urine, and tissue extracts.

3. Nuclear Magnetic Resonance (NMR) Studies:
   The deuterium substitution reduces proton signal interference, improving the clarity of ¹H NMR and ¹³C NMR spectra. It is valuable for structure elucidation and kinetic isotope effect (KIE) measurements in biochemical reactions.

4. Pharmaceutical and Nutritional Research:
   In drug metabolism and nutritional biochemistry, Meso-Erythritol-d6 serves as a reference compound for studying absorption, transport, and metabolic fate of polyols, aiding in pharmacokinetic and dietary assessment studies.

5. Isotope Dilution Quantification:
   Used in isotope-dilution mass spectrometry (IDMS), this compound provides unmatched precision for quantitative determination of sugar alcohols in food, pharmaceuticals, and biological samples.

6. Kinetic and Mechanistic Studies:
   Deuterated erythritol enables investigation of reaction kinetics, hydrogen-deuterium exchange, and isotope effects in enzymatic catalysis and oxidative degradation pathways.

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ANALYTICAL ADVANTAGES

• High deuterium enrichment (≥98 atom % D) for clear isotopic distinction

• Excellent stability and water solubility

• Chemically identical to natural erythritol, ensuring consistent analytical response

• Perfect internal standard for mass spectrometry calibration

• Improved NMR spectral clarity due to proton signal reduction

• Non-radioactive, safe, and environmentally stable isotope tracer

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QUALITY AND MANUFACTURING
At ResolveMass Laboratories Inc., Meso-Erythritol-1,1,2,3,4,4-d6 is synthesized using proprietary isotopic labeling techniques and refined through advanced purification systems to ensure maximum chemical and isotopic purity. Each production batch undergoes rigorous analytical testing using GC-MS, LC-MS, and NMR spectroscopy to confirm structural integrity, isotopic labeling efficiency, and chemical composition.

Our quality assurance process ensures that every product meets the highest research-grade standards, suitable for bioanalytical, pharmaceutical, and academic research. The consistency and traceability of ResolveMass deuterated standards provide scientists with reliable materials for high-accuracy experiments and regulatory-compliant analyses.

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CONCLUSION
Meso-Erythritol-1,1,2,3,4,4-d6 is a premium-quality deuterated polyol designed for use in isotope tracing, mass spectrometry calibration, and metabolic analysis. Its exceptional isotopic enrichment, purity, and chemical equivalence to natural erythritol make it a superior standard for precise quantitative and mechanistic studies. With ResolveMass Laboratories Inc. as your trusted supplier, researchers can depend on consistent product performance, analytical reliability, and uncompromising quality for cutting-edge bioanalytical and biochemical research.

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