Morpholine-2,2,3,3,5,5,6,6-d8 HCl | CAS 1107650-56-5

OVERVIEW  of  Morpholine-2,2,3,3,5,5,6,6-d8 HCl | CAS 1107650-56-5

Morpholine-2,2,3,3,5,5,6,6-d₈ hydrochloride (CAS 1107650-56-5) is the deuterated hydrochloride salt of morpholine, in which all eight carbon-bound hydrogens are replaced with deuterium. This isotopically labeled compound offers high chemical and isotopic purity, making it an ideal internal standard and reference material for mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies. Its salt form provides enhanced stability, solubility, and handling convenience, while retaining the same reactivity and functional properties as non-deuterated morpholine hydrochloride.

CHEMICAL INFORMATION

• Name: Morpholine-d₈ hydrochloride

• Molecular Formula: C₄D₈ClNO

• Molecular Weight: 131.63 g/mol

• CAS Number: 1107650-56-5

• Isotopic Enrichment: ≥ 98 atom % D

• Solubility: Freely soluble in water and methanol; moderately soluble in ethanol

APPLICATIONS  of  Morpholine-2,2,3,3,5,5,6,6-d8 HCl | CAS 1107650-56-5

• Mass Spectrometry (MS):
  Used as a stable isotope-labeled internal standard for quantitative determination of morpholine and its derivatives in complex matrices. It aids in enhancing analytical precision and calibration accuracy.

• Nuclear Magnetic Resonance (NMR):
  Serves as a deuterated reference compound that improves spectral resolution by minimizing proton interference, making it suitable for detailed structural and kinetic studies.

• Pharmaceutical and Biochemical Research:
  Acts as a metabolic tracer or isotopically labeled analog to monitor morpholine-containing drugs or intermediates during metabolic and pharmacokinetic evaluations.

• Analytical Chemistry:
  Applied in method development, validation, and isotopic dilution analysis to ensure accuracy and reproducibility in chemical quantitation.

• Synthetic Chemistry:
  Used as a deuterated building block in the synthesis of labeled pharmaceutical intermediates and heterocyclic compounds.

ADVANTAGES  of  Morpholine-2,2,3,3,5,5,6,6-d8 HCl | CAS 1107650-56-5

• High isotopic enrichment ensures strong isotopic signal separation and analytical precision.

• Hydrochloride salt form enhances compound stability and handling convenience.

• Chemically equivalent to morpholine HCl, enabling direct substitution in analytical and synthetic protocols.

• Non-radioactive, safe for routine laboratory use.

• Provides excellent reproducibility and reduced background noise in MS and NMR analyses.

HANDLING AND SAFETY

• Handling: Avoid inhalation and direct contact with skin and eyes; use appropriate personal protective equipment (PPE).

• Storage: Keep container tightly closed, stored at 2–8 °C in a dry environment.

• Safety: May cause mild irritation; handle under standard laboratory safety practices.

• Disposal: Dispose of according to institutional and regional chemical waste regulations.

SUMMARY
Morpholine-2,2,3,3,5,5,6,6-d₈ hydrochloride (CAS 1107650-56-5) is a high-purity, deuterium-labeled derivative of morpholine HCl, widely employed in analytical, spectroscopic, and pharmaceutical research. Its superior isotopic enrichment and stability make it a preferred internal standard for mass spectrometry and NMR spectroscopy, providing reliable results in isotopic quantification, structural elucidation, and metabolic tracing studies.